Prof. BİRSEN TOZKOPARAN KÖPRÜCÜ

Publication Network

Journal articles indexed in SCI, SSCI, and AHCI

Some novel 5-benzylidenethiazolo[3,2-b]-1,2,4-triazole-6(5H)-one derivatives in the battle against cancer: Design, synthesis and their biological activities

AVCI A., Aztopal N., Gokhan-Kelekci N., ULUKAYA E., TOZKOPARAN KÖPRÜCÜ B.

JOURNAL OF MOLECULAR STRUCTURE , 2025 (SCI-Expanded)

Synthesis, characterization, and MAO inhibitory activities of three new drug-like<i> N</i>-acylhydrazone derivatives

TAŞCİ H., HÖKELEK T., SAĞLIK ÖZKAN B. N., KAYNAK F. B., TOZKOPARAN KÖPRÜCÜ B., GÖKHAN KELEKÇİ N.

JOURNAL OF MOLECULAR STRUCTURE , vol.1318, 2024 (SCI-Expanded)

A new triazolothiadiazine derivative inhibits stemness and induces cell death in HCC by oxidative stress dependent JNK pathway activation

KAHRAMAN D. C., Guven E. B., Aytac P. S., Aykut G., TOZKOPARAN KÖPRÜCÜ B., Atalay R. C.

SCIENTIFIC REPORTS , vol.12, no.1, 2022 (SCI-Expanded)

Design, Synthesis and Biological Evaluation of Novel Triazolothiadiazoles Derived from NSAIDs as Anticancer Agents

Aytac P., Sahin I. D., ATALAY R., TOZKOPARAN KÖPRÜCÜ B.

ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY , vol.22, no.7, pp.1340-1347, 2022 (SCI-Expanded) Sustainable Development

Synthesis and structural characterization of 3-[1-[4-(2-methylpropyl)phenyl] ethyl]-6-(4-fluorophenyl)-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazole

Gundogdu G., KARAYEL A., AYTAÇ S. P., TOZKOPARAN KÖPRÜCÜ B., KAYNAK F. B.

POWDER DIFFRACTION , vol.34, no.4, pp.325-330, 2019 (SCI-Expanded)

Structure determination of two structural analogs, named 3-[1-(2-fluoro-4-biphenyl)ethyl]-6-(4-fluorophenyl)-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazole(C23H16F2N4S) and 3-[1-(2-fluoro-4-biphenyl)ethyl]-6-(4-chlorophenyl)-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazole (C23H16ClFN4S) by synchrotron X-raypowder diffraction

GÜNDOĞDU G., AYTAÇ S. P., MELANİE M., TOZKOPARAN B., KAYNAK F. B.

Powder Diffraction , vol.32, pp.279-289, 2017 (SCI-Expanded)

Structure elucidation of 3-[1-(6-methoxy-2-naphtyl)ethyl]-6-(2,4-dichlorophenyl)-7H-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazine, C23H18Cl2N4OSfrom synchrotron X-ray powder diffraction

GÜNDOĞDU G., AYTAÇ S. P., MELANİE M., TOZKOPARAN B., KAYNAK F. B.

Powder Diffraction , vol.34, pp.271-278, 2017 (SCI-Expanded)

Design and Synthesis of 1,2,4-Triazolo[3,2-b]-1,3,5-thiadiazine Derivatives as a Novel Template for Analgesic/Anti-Inflammatory Activity

Sert-Ozgur S., TEL B. C., Somuncuoglu E. I., KAZKAYASI İ., Ertan M., Tozkoparan B.

ARCHIV DER PHARMAZIE , vol.350, no.7, 2017 (SCI-Expanded)

Novel triazolothiadiazines act as potent anticancer agents in liver cancer cells through Akt and ASK-1 proteins

Aytac P. S., Durmaz I., Houston D. R., Cetin-Atalay R., TOZKOPARAN KÖPRÜCÜ B.

BIOORGANIC & MEDICINAL CHEMISTRY , vol.24, no.4, pp.858-872, 2016 (SCI-Expanded)

Crystal structure determination of two novel 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazine and -thiadiazole derivatives by XRPD method

KAYNAK F. B., Gundogdu G., Muller M., ÖZBEY S.

ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES , vol.72, 2016 (SCI-Expanded)

Novel thiazolo[3,2-b]-1,2,4-triazoles derived from naproxen with analgesic/anti-inflammatory properties: Synthesis, biological evaluation and molecular modeling studies

SARIGOL D., UZGOREN-BARAN A., TEL B. C., Somuncuoglu E. İ., KAZKAYASI İ., OZADALI-SARI K., et al.

BIOORGANIC & MEDICINAL CHEMISTRY , vol.23, no.10, pp.2518-2528, 2015 (SCI-Expanded)

Thiazolo[3,2-b]-1,2,4-triazole-5(6H)-one substituted with ibuprofen: Novel non-steroidal anti-inflammatory agents with favorable gastrointestinal tolerance

Uzgoren-Baran A., TEL B. C., SARIGOL D., Ozturk E. I., KAZKAYASI İ., Okay G., et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY , vol.57, pp.398-406, 2012 (SCI-Expanded)

Design and synthesis of some thiazolotriazolyl esters as anti-inflammatory and analgesic agents

Tozkoparan B., AYTAÇ S. A., Gursoy S., AKTAY G.

MEDICINAL CHEMISTRY RESEARCH , vol.21, no.2, pp.192-201, 2012 (SCI-Expanded) Sustainable Development

Novel 1,2,4-Triazolo[3,4-b]-1,3,4-thiadiazole Derivatives as Dual Analgesic/Anti-inflammatory and Antimicrobial Agents

Tozkoparan B., Aytac S. P., Gursoy S., GÜNAL S., AKTAY G.

LETTERS IN DRUG DESIGN & DISCOVERY , vol.9, no.2, pp.204-212, 2012 (SCI-Expanded)

A joint theoretical and experimental structural study of two novel 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazine derivatives

Kaynak F. B., Aytac S. P., Tozkoparan B.

STRUCTURAL CHEMISTRY , vol.21, no.4, pp.795-802, 2010 (SCI-Expanded)

Synthesis of 3,6-disubstituted 7H-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazines as novel analgesic/anti-inflammatory compounds

AYTAÇ S. A., Tozkoparan B., KAYNAK F. B., Aktay G., Goektas O., Uenuevar S.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY , vol.44, no.11, pp.4528-4538, 2009 (SCI-Expanded)

Novel 3,6-Disubstituted 7H-1,2,4-Triazolo[3,4-b][1,3,4]thiadiazines: Synthesis, Characterization, and Evaluation of Analgesic/Anti-inflammatory, Antioxidant Activities

Tozkoparan B., Aytac S. P., Aktay G.

ARCHIV DER PHARMAZIE , vol.342, no.5, pp.291-298, 2009 (SCI-Expanded)

Investigation of antioxidant properties of some 6-(alpha-aminobenzyl) thiazolo[3,2-b]-1,2,4-triazole-5-ol compounds

AKTAY G., Tozkoparan B., Ertan M.

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY , vol.24, no.3, pp.898-902, 2009 (SCI-Expanded)

The antioxidant properties and the COX-inhibitory effects of some 6-(a-aminobenzyl) thiazolo [3,2-b]-1,2,4-triazole-5-ol compounds

Aktay G., Tozkoparan B., Ertan M.

BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY , vol.102, pp.44, 2008 (SCI-Expanded)

Preparation of 5-aryl-3-alkylthio-1,2,4-triazoles and corresponding sulfones with antiinflammatory-analgesic activity

Tozkoparan B., KUPELI E., YESILADA E., Ertan M.

BIOORGANIC & MEDICINAL CHEMISTRY , vol.15, no.4, pp.1808-1814, 2007 (SCI-Expanded)

Design and synthesis of some new thiazolo[3,2-b]-1,2,4-triazole-5(6H)-ones substituted with flurbiprofen as anti-inflammatory and analgesic agents

DOĞDAŞ E., TOZKOPARAN B., KAYNAK F. B., ERİKSSON L., KUPELI E., YEŞİLADA E., et al.

ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH , vol.57, no.4, pp.196-202, 2007 (SCI-Expanded) Sustainable Development

Design and synthesis of some new thiazolo[3,2-b]-1,2,4-triazole-5(6H)-ones substituted with flurbiprofen as anti-inflammatory and analgesic agents

DOĞDAŞ E., Tozkoparan B., Kaynak F. B., ERİKSSON L., KUPELI E., YESILADA E., et al.

ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH , vol.57, no.4, pp.196-202, 2007 (SCI-Expanded) Sustainable Development

3-phenyl-5-(2-thienyl)-2-pyrazoline-1-thioamide

Isik S., Koysal Y., Ozdemir Z., Bilgin A.

ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS , vol.62, 2006 (SCI-Expanded)

Two N-substituted 3,5-diphenyl-2-pyrazoline-1-thiocarboxamides

Koysal Y., Isik S., Sahin G., Palaska E.

ACTA CRYSTALLOGRAPHICA SECTION C-STRUCTURAL CHEMISTRY , vol.61, 2005 (SCI-Expanded)

1-[(2-Chloro-3,4-dimethoxybenzylidene)amino]-adamantane

Isik S., Koysal Y., Septioglu E., Calis U.

ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS , vol.61, 2005 (SCI-Expanded)

2-[(2-Chloro-3,4-dimethoxybenzylidene)amino]-adamantane

Isik S., Koysal Y., Septioglu E., Calis U.

ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS , vol.61, 2005 (SCI-Expanded)

Protective effects of thiazolo[3,2-b]-1,2,4-triazoles on ethanol-induced oxidative stress in mouse brain and liver

AKTAY G., Tozkoparan B., ERTAN M.

ARCHIVES OF PHARMACAL RESEARCH , vol.28, no.4, pp.438-442, 2005 (SCI-Expanded)

Synthesis and evaluation of analgesic/anti-inflammatory and antimicrobial activities of 3-substituted-1,2,4-triazole-5-thiones

Tozkoparan B., KUPELI E., YESILADA E., ISIK S., OZALP M. A., ERTAN M.

ARZNEIMITTELFORSCHUNG-DRUG RESEARCH , vol.55, no.9, pp.533-540, 2005 (SCI-Expanded)

Synthesis and evaluation of analgesic/anti-inflammatory and antimicrobial activities of 3-substituted-1,2,4-triazole-5-thiones

TOZKOPARAN B., KUPELI E., YEŞİLADA E., Isik S., ÖZALP M., Ertan M.

ARZNEIMITTELFORSCHUNG-DRUG RESEARCH , vol.55, no.9, pp.533-540, 2005 (SCI-Expanded)

5-(2-chlorobenzoyl)-1,3-benzoxazol-2(3H)-one

Isik S., Koysal Y., Yavuz M., Koksal M., Erdogan H.

ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS , vol.60, 2004 (SCI-Expanded)

2-[6-(3-Chlorophenyl)-2,4-dioxo-perhydropyrimidin-3-yl]ethyl morpholine-4-carbodithioate

Koysal Y., Isik S., Septioglu E., Calis U.

ACTA CRYSTALLOGRAPHICA SECTION C-STRUCTURAL CHEMISTRY , vol.60, 2004 (SCI-Expanded)

6-(2-Fluorobenzylidene)-2-[1-(2-fluoro-4-biphenyl)ethyl]-thiazolo[3,2-b][1,2,4]triazol-5(6H)-one

KOYSAL Y., ISIK S., DOGDAS E., Tozkoparan B., ERTAN M.

ACTA CRYSTALLOGRAPHICA SECTION C-STRUCTURAL CHEMISTRY , vol.60, 2004 (SCI-Expanded)

3-[4-(4-Fluorophenyl)piperazin-1-ylmethyl]-5-methyl-1,3-benzoxazol-2(3H)-one and 3-[4-(2-fluorophenyl)piperazin-1-ylmethyl]-5-methyl-1,3-benzoxazol-2 (3H)-one

Koysal Y., Isik S., Koksal M., Erdogan H., Gokhan N.

ACTA CRYSTALLOGRAPHICA SECTION C-STRUCTURAL CHEMISTRY , vol.60, 2004 (SCI-Expanded)

Synthesis, characterization and anti-inflammatory-analgesic properties of 6-(alpha-amino-4-chlorobenzyl)thiazolo[3,2-b]-1,2,4-triazol-5-ols

Tozkoparan B., Gokhan N., KUPELI E., YESILADA E., ERTAN M.

ARZNEIMITTELFORSCHUNG-DRUG RESEARCH , vol.54, no.1, pp.35-41, 2004 (SCI-Expanded)

3-[4-(2-Chlorophenyl)piperazinomethyl]-5-methyl-1-benzoxazolin-2(3H)-one

Koysal Y., Isik S., Koksal M., Erdogan H., Gokhan N.

ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE , vol.59, 2003 (SCI-Expanded)

Methyl 2-methyl-7-oxo-1,2,4-triazolo[3,2-b]-1,3-thiazine-5-carboxylate

OZBEY S., Tozkoparan B.

ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE , vol.58, 2002 (SCI-Expanded)

Synthesis of some 1,2,4-triazolo[3,2-b]-1,3-thiazine-7-ones with potential analgesic and antiinflammatory activities

Tozkoparan B., AKTAY G., YESILADA E.

FARMACO , vol.57, no.2, pp.145-152, 2002 (SCI-Expanded) Sustainable Development

Synthesis of some thiazolo[3,2-b]-1,2,4-triazole-5(6H)-ones and their novel Michael addition products with anti-inflammatory activities

Tozkoparan B., AKTAY G., YESILADA E., ERTAN M.

ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH , vol.51, no.6, pp.470-477, 2001 (SCI-Expanded)

Studies on synthesis, chromatographic resolution, and antiinflammatory activities of some 2-thioxo-1,2,3,4-tetrahydropyrimidines and their condensed derivatives

Tozkoparan B., YARIM M., Sarac S., ERTAN M., Kelicen P., ALTINOK G., et al.

ARCHIV DER PHARMAZIE , vol.333, no.12, pp.415-420, 2000 (SCI-Expanded)

6-benzylidenethiazolo[3,2-b]-1,2,4-triazole-5(6H)-ones substituted with ibuprofen: synthesis, characterization and evaluation of anti-inflammatory activity

Tozkoparan B., GOKHAN N., AKTAY G., YESILADA E., ERTAN M.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY , vol.35, pp.743-750, 2000 (SCI-Expanded)

Synthesis and evaluation of anti-inflammatory activity of some thiazolo[3,2-b]-1,2,4-triazole-5(6H)-ones and their Michael addition products

Tozkoparan B., KILCIGIL G., ERTAN R., ERTAN M., Kelicen P., DEMIRDAMAR R.

ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH , vol.49, no.12, pp.1006-1011, 1999 (SCI-Expanded)

6-Benzylidene-2-(2-chlorophenyl)thiazolo[3,2-b]-1,2,4-triazol-5(6H)-one

OZBEY S., KENDI E., Tozkoparan B., ERTAN M.

ACTA CRYSTALLOGRAPHICA SECTION C-CRYSTAL STRUCTURE COMMUNICATIONS , vol.55, pp.1939-1941, 1999 (SCI-Expanded)

Synthesis and anti-inflammatory activities of some thiazolo[3,2-a]pyrimidine derivatives

Tozkoparan B., ERTAN M., KELICEN P., DEMIRDAMAR R.

FARMACO , vol.54, no.9, pp.588-593, 1999 (SCI-Expanded)

Condensed heterocyclic compounds: Synthesis and antiinflammatory activity of novel thiazolo[3,2-a]pyrimidines

Tozkoparan B., ERTAN M., KREBS B., LAGE M., Kelicen P., DEMIRDAMAR R.

ARCHIV DER PHARMAZIE , vol.331, no.6, pp.201-206, 1998 (SCI-Expanded)

Development and validation of a capillary electrophoretic method for the determination of degradation product in naphazoline HCl bulk drug substance

Yesilada A., TOZKOPARAN B., GOKHAN N., ONER L., ERTAN M.

JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES , vol.21, no.17, pp.2575-2588, 1998 (SCI-Expanded)

Method validation in pharmaceutical analysis: From a general approach to capillary electrophoresis

YESILADA A., GOKHAN N., Tozkoparan B., ERTAN M., ABOUL-ENEIN H.

JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES , vol.21, no.17, pp.2619-2632, 1998 (SCI-Expanded)

(1R,2S,4S,11S)-4-isopropyl-1-methyl-2(alpha-N-morpholino-3-methoxybenzyl)cyclohexan-3-one

ERTAN M., YESILADA A., Tozkoparan B., TARIMCI C., KREBS B., LAGE M.

ACTA CRYSTALLOGRAPHICA SECTION C-CRYSTAL STRUCTURE COMMUNICATIONS , vol.53, pp.1466-1468, 1997 (SCI-Expanded)

Synthesis of some 2-arylpropionic acid amides as prodrugs

AKGUN H., Tozkoparan B., ERTAN M., AKSU F., INAN S.

ARZNEIMITTEL-FORSCHUNG/DRUG RESEARCH , vol.46, no.9, pp.891-894, 1996 (SCI-Expanded)

SYNTHESIS OF SOME THIAZOLO[3,2-B]-1,2,4-TRIAZOLE-5(6H)-ONE AS POTENTIAL PLATELET-AGGREGATION INHIBITORS

TOZKOPARAN B., AKGUN H., ERTAN M., RUBSEMANN K.

ARCHIV DER PHARMAZIE , vol.328, no.2, pp.169-173, 1995 (SCI-Expanded)

Articles Published in Other Journals

COMPUTATIONAL IDENTIFICATION OF NOVEL TARGETS FOR DRUG CANDIDATE COMPOUNDS

SUCULARLI C., Tozkoparan B., Aytac S. P.

Journal of Research in Pharmacy , vol.27, pp.9-12, 2023 (ESCI)

Mechanistic studies of inactivation of glutathione S transferase Pi isozyme by a haloenol lactone derivative

JİANG Z., GHANG L., TOZKOPARAN B., WEN D.

Medicinal Chemistry , vol.1, pp.191-198, 2005 (Scopus)

Effects of nonsteroidal antiinflammatory drugs on the thiol groups and lipid peroxidation in ethanol induced oxidative stress

AKTAY G., TOZKOPARAN B., Ertan M.

Acta Pharmaceutica Turcica , vol.46, pp.107-112, 2004 (Peer-Reviewed Journal)

Papers Presented at Peer-Reviewed Scientific Conferences

A NEW THIADIAZINE DERIVATIVE INDUCES OXIDATIVE STRESS DEPENDENT CELL DEATH IN HEPATOCELLULAR CARCINOMA STEM CELLS

KAHRAMAN D. C., GÜVEN E. B., Aytac P., TOZKOPARAN KÖPRÜCÜ B., ATALAY R.

Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases (AASLD) / Liver Meeting, Massachusetts, United States Of America, 8 - 12 November 2019, vol.70, (Summary Text)

A new thiadiazine derivative induces oxidative stress dependent JNK pathway activation and cell death in hepatocellular carcinoma

KAHRAMAN D. C., GÜVEN E. B., TOZKOPARAN KÖPRÜCÜ B., ATALAY R.

Annual Meeting of the American-Association-for-Cancer-Research (AACR), Georgia, United States Of America, 29 March - 03 April 2019, vol.79, (Summary Text)