Prof. BİRSEN TOZKOPARAN KÖPRÜCÜ

Publication Network

Published journal articles indexed by SCI, SSCI, and AHCI

A new triazolothiadiazine derivative inhibits stemness and induces cell death in HCC by oxidative stress dependent JNK pathway activation

KAHRAMAN D. C., Guven E. B., Aytac P. S., Aykut G., TOZKOPARAN KÖPRÜCÜ B., Atalay R. C.

SCIENTIFIC REPORTS, vol.12, no.1, 2022 (SCI-Expanded)

Design, Synthesis and Biological Evaluation of Novel Triazolothiadiazoles Derived from NSAIDs as Anticancer Agents

Aytac P., Sahin I. D., ATALAY R., TOZKOPARAN KÖPRÜCÜ B.

ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, vol.22, no.7, pp.1340-1347, 2022 (SCI-Expanded) Sustainable Development

Synthesis and structural characterization of 3-[1-[4-(2-methylpropyl)phenyl] ethyl]-6-(4-fluorophenyl)-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazole

Gundogdu G., KARAYEL A., AYTAÇ S. P., TOZKOPARAN KÖPRÜCÜ B., KAYNAK F. B.

POWDER DIFFRACTION, vol.34, no.4, pp.325-330, 2019 (SCI-Expanded)

Structure determination of two structural analogs, named 3-[1-(2-fluoro-4-biphenyl)ethyl]-6-(4-fluorophenyl)-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazole(C23H16F2N4S) and 3-[1-(2-fluoro-4-biphenyl)ethyl]-6-(4-chlorophenyl)-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazole (C23H16ClFN4S) by synchrotron X-raypowder diffraction

GÜNDOĞDU G., AYTAÇ S. P., MELANİE M., TOZKOPARAN B., KAYNAK F. B.

Powder Diffraction, vol.32, pp.279-289, 2017 (SCI-Expanded)

Structure elucidation of 3-[1-(6-methoxy-2-naphtyl)ethyl]-6-(2,4-dichlorophenyl)-7H-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazine, C23H18Cl2N4OSfrom synchrotron X-ray powder diffraction

GÜNDOĞDU G., AYTAÇ S. P., MELANİE M., TOZKOPARAN B., KAYNAK F. B.

Powder Diffraction, vol.34, pp.271-278, 2017 (SCI-Expanded)

Design and Synthesis of 1,2,4-Triazolo[3,2-b]-1,3,5-thiadiazine Derivatives as a Novel Template for Analgesic/Anti-Inflammatory Activity

Sert-Ozgur S., TEL B. C., Somuncuoglu E. I., KAZKAYASI İ., Ertan M., Tozkoparan B.

ARCHIV DER PHARMAZIE, vol.350, no.7, 2017 (SCI-Expanded)

Novel triazolothiadiazines act as potent anticancer agents in liver cancer cells through Akt and ASK-1 proteins

Aytac P. S., Durmaz I., Houston D. R., Cetin-Atalay R., TOZKOPARAN KÖPRÜCÜ B.

BIOORGANIC & MEDICINAL CHEMISTRY, vol.24, no.4, pp.858-872, 2016 (SCI-Expanded)

Crystal structure determination of two novel 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazine and -thiadiazole derivatives by XRPD method

KAYNAK F. B., Gundogdu G., Muller M., ÖZBEY S.

ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES, vol.72, 2016 (SCI-Expanded)

Novel thiazolo[3,2-b]-1,2,4-triazoles derived from naproxen with analgesic/anti-inflammatory properties: Synthesis, biological evaluation and molecular modeling studies

SARIGOL D., UZGOREN-BARAN A., TEL B. C., Somuncuoglu E. İ., KAZKAYASI İ., OZADALI-SARI K., et al.

BIOORGANIC & MEDICINAL CHEMISTRY, vol.23, no.10, pp.2518-2528, 2015 (SCI-Expanded)

Thiazolo[3,2-b]-1,2,4-triazole-5(6H)-one substituted with ibuprofen: Novel non-steroidal anti-inflammatory agents with favorable gastrointestinal tolerance

Uzgoren-Baran A., TEL B. C., SARIGOL D., Ozturk E. I., KAZKAYASI İ., Okay G., et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol.57, pp.398-406, 2012 (SCI-Expanded)

Novel 1,2,4-Triazolo[3,4-b]-1,3,4-thiadiazole Derivatives as Dual Analgesic/Anti-inflammatory and Antimicrobial Agents

Tozkoparan B., Aytac S. P., Gursoy S., GÜNAL S., AKTAY G.

LETTERS IN DRUG DESIGN & DISCOVERY, vol.9, no.2, pp.204-212, 2012 (SCI-Expanded)

Design and synthesis of some thiazolotriazolyl esters as anti-inflammatory and analgesic agents

Tozkoparan B., AYTAÇ S. A., Gursoy S., AKTAY G.

MEDICINAL CHEMISTRY RESEARCH, vol.21, no.2, pp.192-201, 2012 (SCI-Expanded) Sustainable Development

A joint theoretical and experimental structural study of two novel 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazine derivatives

Kaynak F. B., Aytac S. P., Tozkoparan B.

STRUCTURAL CHEMISTRY, vol.21, no.4, pp.795-802, 2010 (SCI-Expanded)

Synthesis of 3,6-disubstituted 7H-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazines as novel analgesic/anti-inflammatory compounds

AYTAÇ S. A., Tozkoparan B., KAYNAK F. B., Aktay G., Goektas O., Uenuevar S.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol.44, no.11, pp.4528-4538, 2009 (SCI-Expanded)

Novel 3,6-Disubstituted 7H-1,2,4-Triazolo[3,4-b][1,3,4]thiadiazines: Synthesis, Characterization, and Evaluation of Analgesic/Anti-inflammatory, Antioxidant Activities

Tozkoparan B., Aytac S. P., Aktay G.

ARCHIV DER PHARMAZIE, vol.342, no.5, pp.291-298, 2009 (SCI-Expanded)

Investigation of antioxidant properties of some 6-(alpha-aminobenzyl) thiazolo[3,2-b]-1,2,4-triazole-5-ol compounds

AKTAY G., Tozkoparan B., Ertan M.

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol.24, no.3, pp.898-902, 2009 (SCI-Expanded)

The antioxidant properties and the COX-inhibitory effects of some 6-(a-aminobenzyl) thiazolo [3,2-b]-1,2,4-triazole-5-ol compounds

Aktay G., Tozkoparan B., Ertan M.

BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY, vol.102, pp.44, 2008 (SCI-Expanded)

Preparation of 5-aryl-3-alkylthio-1,2,4-triazoles and corresponding sulfones with antiinflammatory-analgesic activity

Tozkoparan B., KUPELI E., YESILADA E., Ertan M.

BIOORGANIC & MEDICINAL CHEMISTRY, vol.15, no.4, pp.1808-1814, 2007 (SCI-Expanded)

Design and synthesis of some new thiazolo[3,2-b]-1,2,4-triazole-5(6H)-ones substituted with flurbiprofen as anti-inflammatory and analgesic agents

DOĞDAŞ E., Tozkoparan B., Kaynak F. B., ERİKSSON L., KUPELI E., YESILADA E., et al.

ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH, vol.57, no.4, pp.196-202, 2007 (SCI-Expanded) Sustainable Development

Design and synthesis of some new thiazolo[3,2-b]-1,2,4-triazole-5(6H)-ones substituted with flurbiprofen as anti-inflammatory and analgesic agents

DOĞDAŞ E., TOZKOPARAN B., KAYNAK F. B., ERİKSSON L., KUPELI E., YEŞİLADA E., et al.

ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH, vol.57, no.4, pp.196-202, 2007 (SCI-Expanded) Sustainable Development

3-phenyl-5-(2-thienyl)-2-pyrazoline-1-thioamide

Isik S., Koysal Y., Ozdemir Z., Bilgin A.

ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS, vol.62, 2006 (SCI-Expanded)

Two N-substituted 3,5-diphenyl-2-pyrazoline-1-thiocarboxamides

Koysal Y., Isik S., Sahin G., Palaska E.

ACTA CRYSTALLOGRAPHICA SECTION C-STRUCTURAL CHEMISTRY, vol.61, 2005 (SCI-Expanded)

2-[(2-Chloro-3,4-dimethoxybenzylidene)amino]-adamantane

Isik S., Koysal Y., Septioglu E., Calis U.

ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS, vol.61, 2005 (SCI-Expanded)

1-[(2-Chloro-3,4-dimethoxybenzylidene)amino]-adamantane

Isik S., Koysal Y., Septioglu E., Calis U.

ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS, vol.61, 2005 (SCI-Expanded)

Protective effects of thiazolo[3,2-b]-1,2,4-triazoles on ethanol-induced oxidative stress in mouse brain and liver

AKTAY G., Tozkoparan B., ERTAN M.

ARCHIVES OF PHARMACAL RESEARCH, vol.28, no.4, pp.438-442, 2005 (SCI-Expanded)

Synthesis and evaluation of analgesic/anti-inflammatory and antimicrobial activities of 3-substituted-1,2,4-triazole-5-thiones

Tozkoparan B., KUPELI E., YESILADA E., ISIK S., OZALP M. A., ERTAN M.

ARZNEIMITTELFORSCHUNG-DRUG RESEARCH, vol.55, no.9, pp.533-540, 2005 (SCI-Expanded)

Synthesis and evaluation of analgesic/anti-inflammatory and antimicrobial activities of 3-substituted-1,2,4-triazole-5-thiones

TOZKOPARAN B., KUPELI E., YEŞİLADA E., Isik S., ÖZALP M., Ertan M.

ARZNEIMITTELFORSCHUNG-DRUG RESEARCH, vol.55, no.9, pp.533-540, 2005 (SCI-Expanded)

5-(2-chlorobenzoyl)-1,3-benzoxazol-2(3H)-one

Isik S., Koysal Y., Yavuz M., Koksal M., Erdogan H.

ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS, vol.60, 2004 (SCI-Expanded)

2-[6-(3-Chlorophenyl)-2,4-dioxo-perhydropyrimidin-3-yl]ethyl morpholine-4-carbodithioate

Koysal Y., Isik S., Septioglu E., Calis U.

ACTA CRYSTALLOGRAPHICA SECTION C-STRUCTURAL CHEMISTRY, vol.60, 2004 (SCI-Expanded)

6-(2-Fluorobenzylidene)-2-[1-(2-fluoro-4-biphenyl)ethyl]-thiazolo[3,2-b][1,2,4]triazol-5(6H)-one

KOYSAL Y., ISIK S., DOGDAS E., Tozkoparan B., ERTAN M.

ACTA CRYSTALLOGRAPHICA SECTION C-STRUCTURAL CHEMISTRY, vol.60, 2004 (SCI-Expanded)

3-[4-(4-Fluorophenyl)piperazin-1-ylmethyl]-5-methyl-1,3-benzoxazol-2(3H)-one and 3-[4-(2-fluorophenyl)piperazin-1-ylmethyl]-5-methyl-1,3-benzoxazol-2 (3H)-one

Koysal Y., Isik S., Koksal M., Erdogan H., Gokhan N.

ACTA CRYSTALLOGRAPHICA SECTION C-STRUCTURAL CHEMISTRY, vol.60, 2004 (SCI-Expanded)

Synthesis, characterization and anti-inflammatory-analgesic properties of 6-(alpha-amino-4-chlorobenzyl)thiazolo[3,2-b]-1,2,4-triazol-5-ols

Tozkoparan B., Gokhan N., KUPELI E., YESILADA E., ERTAN M.

ARZNEIMITTELFORSCHUNG-DRUG RESEARCH, vol.54, no.1, pp.35-41, 2004 (SCI-Expanded)

3-[4-(2-Chlorophenyl)piperazinomethyl]-5-methyl-1-benzoxazolin-2(3H)-one

Koysal Y., Isik S., Koksal M., Erdogan H., Gokhan N.

ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, vol.59, 2003 (SCI-Expanded)

Methyl 2-methyl-7-oxo-1,2,4-triazolo[3,2-b]-1,3-thiazine-5-carboxylate

OZBEY S., Tozkoparan B.

ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, vol.58, 2002 (SCI-Expanded)

Synthesis of some 1,2,4-triazolo[3,2-b]-1,3-thiazine-7-ones with potential analgesic and antiinflammatory activities

Tozkoparan B., AKTAY G., YESILADA E.

FARMACO, vol.57, no.2, pp.145-152, 2002 (SCI-Expanded) Sustainable Development

Synthesis of some thiazolo[3,2-b]-1,2,4-triazole-5(6H)-ones and their novel Michael addition products with anti-inflammatory activities

Tozkoparan B., AKTAY G., YESILADA E., ERTAN M.

ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH, vol.51, no.6, pp.470-477, 2001 (SCI-Expanded)

Studies on synthesis, chromatographic resolution, and antiinflammatory activities of some 2-thioxo-1,2,3,4-tetrahydropyrimidines and their condensed derivatives

Tozkoparan B., YARIM M., Sarac S., ERTAN M., Kelicen P., ALTINOK G., et al.

ARCHIV DER PHARMAZIE, vol.333, no.12, pp.415-420, 2000 (SCI-Expanded)

6-benzylidenethiazolo[3,2-b]-1,2,4-triazole-5(6H)-ones substituted with ibuprofen: synthesis, characterization and evaluation of anti-inflammatory activity

Tozkoparan B., GOKHAN N., AKTAY G., YESILADA E., ERTAN M.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol.35, pp.743-750, 2000 (SCI-Expanded)

Synthesis and evaluation of anti-inflammatory activity of some thiazolo[3,2-b]-1,2,4-triazole-5(6H)-ones and their Michael addition products

Tozkoparan B., KILCIGIL G., ERTAN R., ERTAN M., Kelicen P., DEMIRDAMAR R.

ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH, vol.49, no.12, pp.1006-1011, 1999 (SCI-Expanded)

6-Benzylidene-2-(2-chlorophenyl)thiazolo[3,2-b]-1,2,4-triazol-5(6H)-one

OZBEY S., KENDI E., Tozkoparan B., ERTAN M.

ACTA CRYSTALLOGRAPHICA SECTION C-CRYSTAL STRUCTURE COMMUNICATIONS, vol.55, pp.1939-1941, 1999 (SCI-Expanded)

Synthesis and anti-inflammatory activities of some thiazolo[3,2-a]pyrimidine derivatives

Tozkoparan B., ERTAN M., KELICEN P., DEMIRDAMAR R.

FARMACO, vol.54, no.9, pp.588-593, 1999 (SCI-Expanded)

Condensed heterocyclic compounds: Synthesis and antiinflammatory activity of novel thiazolo[3,2-a]pyrimidines

Tozkoparan B., ERTAN M., KREBS B., LAGE M., Kelicen P., DEMIRDAMAR R.

ARCHIV DER PHARMAZIE, vol.331, no.6, pp.201-206, 1998 (SCI-Expanded)

Method validation in pharmaceutical analysis: From a general approach to capillary electrophoresis

YESILADA A., GOKHAN N., Tozkoparan B., ERTAN M., ABOUL-ENEIN H.

JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES, vol.21, no.17, pp.2619-2632, 1998 (SCI-Expanded)

Development and validation of a capillary electrophoretic method for the determination of degradation product in naphazoline HCl bulk drug substance

Yesilada A., TOZKOPARAN B., GOKHAN N., ONER L., ERTAN M.

JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES, vol.21, no.17, pp.2575-2588, 1998 (SCI-Expanded)

(1R,2S,4S,11S)-4-isopropyl-1-methyl-2(alpha-N-morpholino-3-methoxybenzyl)cyclohexan-3-one

ERTAN M., YESILADA A., Tozkoparan B., TARIMCI C., KREBS B., LAGE M.

ACTA CRYSTALLOGRAPHICA SECTION C-CRYSTAL STRUCTURE COMMUNICATIONS, vol.53, pp.1466-1468, 1997 (SCI-Expanded)

Synthesis of some 2-arylpropionic acid amides as prodrugs

AKGUN H., Tozkoparan B., ERTAN M., AKSU F., INAN S.

ARZNEIMITTEL-FORSCHUNG/DRUG RESEARCH, vol.46, no.9, pp.891-894, 1996 (SCI-Expanded)

SYNTHESIS OF SOME THIAZOLO[3,2-B]-1,2,4-TRIAZOLE-5(6H)-ONE AS POTENTIAL PLATELET-AGGREGATION INHIBITORS

TOZKOPARAN B., AKGUN H., ERTAN M., RUBSEMANN K.

ARCHIV DER PHARMAZIE, vol.328, no.2, pp.169-173, 1995 (SCI-Expanded)

Articles Published in Other Journals

Mechanistic studies of inactivation of glutathione S transferase Pi isozyme by a haloenol lactone derivative

JİANG Z., GHANG L., TOZKOPARAN B., WEN D.

Medicinal Chemistry, vol.1, pp.191-198, 2005 (Scopus)

Effects of nonsteroidal antiinflammatory drugs on the thiol groups and lipid peroxidation in ethanol induced oxidative stress

AKTAY G., TOZKOPARAN B., Ertan M.

Acta Pharmaceutica Turcica, vol.46, pp.107-112, 2004 (Peer-Reviewed Journal)

Refereed Congress / Symposium Publications in Proceedings

A NEW THIADIAZINE DERIVATIVE INDUCES OXIDATIVE STRESS DEPENDENT CELL DEATH IN HEPATOCELLULAR CARCINOMA STEM CELLS

KAHRAMAN D. C., GÜVEN E. B., Aytac P., TOZKOPARAN KÖPRÜCÜ B., ATALAY R.

Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases (AASLD) / Liver Meeting, Massachusetts, United States Of America, 8 - 12 November 2019, vol.70

A new thiadiazine derivative induces oxidative stress dependent JNK pathway activation and cell death in hepatocellular carcinoma

KAHRAMAN D. C., GÜVEN E. B., TOZKOPARAN KÖPRÜCÜ B., ATALAY R.

Annual Meeting of the American-Association-for-Cancer-Research (AACR), Georgia, United States Of America, 29 March - 03 April 2019, vol.79

Computational Activity and Target Prediction for Three Novel Triazolothiadiazine Derivatives

SUCULARLI C., TOZKOPARAN B.

5th International BAU Drug Design Congress, 19 - 21 October 2017

A Valid Scaffold for Monoamine Oxidases Inhibitors

Tasçı H., SAĞLIK B. N., ÖZKAY Y., TOZKOPARAN B., GÖKHAN KELEKÇİ N.

2nd International Gazi Pharma Symposium Series (GPSS-2017), 11 - 13 October 2017

A Study on Synthesis of Novel Mannich Bases Derived From 1,2,4-Triazole-5-thione Containing Naproxen Moiety

TOZKOPARAN B., Tasçı H., GÖKHAN KELEKÇİ N.

2nd International Gazi Pharma Symposium Series (GPSS-2017), 11 - 13 October 2017

Novel Mannich Bases Derived From 1,2,4-Triazole-5-thione Containing Naproxen Moiety as Analgesic/Anti-inflammatory Compounds

Tasçı H., TOZKOPARAN B., GÖKHAN KELEKÇİ N.

Multidisciplinary Symposium on Drug Research and Development 2017(DRD-2017), 5 - 07 October 2017

Synthesis and Evaluation of Novel Hydrazone Derivatives as Monoamine Oxidase Inhibitors

Tasçı H., SAĞLIK B. N., ÖZKAY Y., TOZKOPARAN B., GÖKHAN KELEKÇİ N.

Multidisciplinary Symposium on Drug Research and Development 2017(DRD-2017), 5 - 07 October 2017

New Bis Mannich Bases of 1,2,4-Triazoles with Analgesic/Antiinflammatory Activities

SERT OZGUR S., TEL B. C., KAZKAYASI İ., SOMUNCUOĞLU E. İ., Ertan M., TOZKOPARAN B.

AIMECS2017, Chemistry in Drug Discovery, Design and Development, 23 - 27 July 2017

Protective Effects of New Selective COX 2 Inhibitors on a Rat Model of Severe Acute Pancreatitits

ERİKÇİ A., UÇAR B. İ., Salgın Gökşen U., GÖKHAN KELEKÇİ N., UZGÖREN BARAN A., TOZKOPARAN B., et al.

41.FEBS Congress, Kuşadası-Aydın, Turkey, 3 - 08 September 2016

Protective effects of new selective COX-2 inhibitors on a rat model of severe acute pancreatitis

Erikci A., Ucar B. I., BAYSAL İ., Goksen U. S., Kelekci N. G., Baran A., et al.

41st FEBS Congress on Molecular and Systems Biology for a Better Life, Kusadasi, Turkey, 3 - 08 September 2016, vol.283, pp.246

Novel 1 2 4 Triazole Based Bicyclic Derivatives Bearing Naproxen Moiety As Analgesic Anti Inflammatory Agents

UZGÖREN BARAN A., TEL B. C., SOMUNCUOĞLU E. İ., KAZKAYASI İ., OKAY G., TOZKOPARAN B.

International Multidisciplinary Symposium on Drug Research and Development in Memory of Professor Ünsal Çalış, Eskişehir, Turkey, 15 - 17 October 2015