Condensed heterocyclic compounds: Synthesis and antiinflammatory activity of novel thiazolo[3,2-a]pyrimidines


Tozkoparan B. , ERTAN M. , KREBS B., LAGE M., Kelicen P., DEMIRDAMAR R.

ARCHIV DER PHARMAZIE, cilt.331, sa.6, ss.201-206, 1998 (SCI İndekslerine Giren Dergi) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 331 Konu: 6
  • Basım Tarihi: 1998
  • Dergi Adı: ARCHIV DER PHARMAZIE
  • Sayfa Sayıları: ss.201-206

Özet

In this study, thirty six new 2-benzylidene-7-methyl-3-oxo-5-phenyl-2,3 -dihydro-5H-thiazolo [3,2-a]pyrimidine-6-carboxylic acid methyl esters were synthesized and characterized by spectral, crystallographic, and elemental analysis. The antiinflammatory activity of the compounds was tested by the carrageenan hind paw edema test. It was found that compound 6a having a 2-methoxyphenyl group at position 5 and a benzylidene group at position 2 was the most potent compound in this series. All the compounds that were tested for ulcer activity gave positive results.