Synthesis, characterization and anti-inflammatory-analgesic properties of 6-(α-amino-4-chlorobenzyl)thiazolo[3,2-b]-1,2,4-triazol-5-ols

Tozkoparan, BİRSEN; Gokhan, NESRİN; KUPELI, E; YESILADA, E; ERTAN, MEVLÜT

Synthesis, characterization and anti-inflammatory-analgesic properties of 6-(α-amino-4-chlorobenzyl)thiazolo[3,2-b]-1,2,4-triazol-5-ols

Tozkoparan B., Gokhan N., KUPELI E., YESILADA E., ERTAN M.

ARZNEIMITTELFORSCHUNG-DRUG RESEARCH, cilt.54, sa.1, ss.35-41, 2004 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 54 Sayı: 1
Basım Tarihi: 2004
Dergi Adı: ARZNEIMITTELFORSCHUNG-DRUG RESEARCH
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Index Chemicus (IC)
Sayfa Sayıları: ss.35-41
Hacettepe Üniversitesi Adresli: Evet

Özet

A series of 6-(alpha-amino-4-chlorobenzyl) thiazolo[3,2-b]-1,2,4-triazol-5-ols (2a-j) were synthesized from 6-(4-chlorobenzylidene)thiazolo[3,2-b]-1,2,4-triazolo-5(6H)-one (2) by applying Michael addition reaction. All the compounds were characterized by their melting points, elementary analysis, IR and H-1-NMR spectra and screened for their anti-inflammatory and analgesic activities. Among the derivatives compound 2i bearing 4-(4-acetylphenyl)piperazine showed the highest and dose-dependent analgesic and anti-inflammatory activity without inducing any gastric lesion.