Studies on synthesis, chromatographic resolution, and antiinflammatory activities of some 2-thioxo-1,2,3,4-tetrahydropyrimidines and their condensed derivatives

Tozkoparan B. , YARIM M., Sarac S. , ERTAN M. , Kelicen P., ALTINOK G., ...Daha Fazla

ARCHIV DER PHARMAZIE, cilt.333, sa.12, ss.415-420, 2000 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 333 Konu: 12
  • Basım Tarihi: 2000
  • Sayfa Sayıları: ss.415-420


In this study, the synthesis of some new 2-thioxo-1,2,3,4-tetrahydropyrimidines and their condensed derivatives, thiazolo[3,2-a]pyrimidines, are described. The structures of the compounds were confirmed by IR, H-1-NMR, C-13-NMR, and mass spectroscopy. The direct high-performance liquid chromatographic separation of the compounds on derivatized cellulose chiral stationary phases such as cellulose tris(3,5-dimethylphenylcarbamate) (OD), cellulose tris(4-methylphenylcarbamate) (OG), and cellulose tris(4-methylbenzoate) (OJ) was studied. All of the compounds were screened for their antiinflammatory activity and also investigated histopathologically. Compounds 3 and la were found to be the most promising antiinflammatory agents in this group.