Novel 3,6-Disubstituted 7H-1,2,4-Triazolo[3,4-b][1,3,4]thiadiazines: Synthesis, Characterization, and Evaluation of Analgesic/Anti-inflammatory, Antioxidant Activities


Tozkoparan B. , Aytac S. P. , Aktay G.

ARCHIV DER PHARMAZIE, cilt.342, ss.291-298, 2009 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 342 Konu: 5
  • Basım Tarihi: 2009
  • Doi Numarası: 10.1002/ardp.200800188
  • Dergi Adı: ARCHIV DER PHARMAZIE
  • Sayfa Sayıları: ss.291-298

Özet

In this study, the synthesis of a new series of 3,6-disubstituted-7H-1,2,4-triazolo[3,4-b][1,3,4]thiadiazine 1a-4c Compounds derived from 4-amino-3-substituted-1,2,4-triazole-5-thiones 1-4 is described. All of the synthesized compounds were screened for their possible analgesic / anti-inflammatory, antioxidant activities and gastric toxicity. The compound 2c was found to have both significant analgesic and consistent anti-inflammatory activity without inducing any gastric lesions along with minimal lipid peroxidation. A deep insight into the structures of the active compounds revealed that the compounds carrying an electron withdrawing group (a chloride or fluoride) on the phenyl ring at 6-position of the condensed heterocyclic derivatives exhibited noticeable higher activity.