6-benzylidenethiazolo[3,2-b]-1,2,4-triazole-5(6H)-ones substituted with ibuprofen:: synthesis, characterization and evaluation of anti-inflammatory activity
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol.35, no.7-8, pp.743-750, 2000 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 35 Issue: 7-8
- Publication Date: 2000
- Doi Number: 10.1016/s0223-5234(00)00157-4
- Journal Name: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Index Chemicus (IC)
- Page Numbers: pp.743-750
- Hacettepe University Affiliated: Yes
Abstract
In this study, the synthesis of 3-[1-(4-(2-methylpropyl)phenyl)ethyl]-1,2,4-triazole-5-thione (2) and its condensed derivatives 6-benzylidenethiazolo[3,2-b]-1,2,4-triazole-5(6H)-ones (2a-u) are described. The structures of the compounds were elucidated by spectral and elemental analysis. In the pharmacological studies, anti-inflammatory activities of these compounds have been screened. Among the compounds examined, the compounds 2 and 2g possessed the most prominent and consistent activity. In gastric ulceration studies the synthesized compounds were generally found to be safe at a 200 mg/kg dose level. (C) 2000 Editions scientifiques et medicales Elsevier SAS.