Synthesis and anti-inflammatory activities of some thiazolo[3,2-a]pyrimidine derivatives

Tozkoparan B., ERTAN M., KELICEN P., DEMIRDAMAR R.

FARMACO, vol.54, no.9, pp.588-593, 1999 (SCI-Expanded) identifier identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 54 Issue: 9
  • Publication Date: 1999
  • Doi Number: 10.1016/s0014-827x(99)00068-3
  • Journal Name: FARMACO
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.588-593
  • Hacettepe University Affiliated: Yes

Abstract

Sixteen new 2-benzylidene-7-methyl-3-oxo-5-(substituted phenyl)-2,3-dihydro-5H-thiazolo[3,2-a]pyrimidine-6-carboxylic acid methyl eaters (1a-4d) have been synthesized by reacting 1,2,3,4-tetrahydropyrimidine-2-thiones (1-4) with chloroacetic acid and appropriate benzaldehydes in a single step. Their structures have been proved by IR, H-1 NMR, mass spectra and elemental analysis. The compounds were tested for their anti-inflammatory activities. Test results revealed that compounds 1b, 1c, 4a and 4c exerted moderate anti-inflammatory activity at the 100 mg/kg dose level compared with indomethacin. (C) 1999 Elsevier Science S.A. All rights reserved.