Prof. Dr. ZEKİYE TUBA TÜYLÜ KÜÇÜKKILINÇ

Yayın Ağı

Makaleler 47

1. Lipoic acid scaffold applications in the design of multitarget-directed ligands against Alzheimer's disease

Manavi M. A., Nourhashemi M., Emami S., Nasab M. H. F., Dehnavi F., Kucukkilinc T. T., et al.

BIOORGANIC CHEMISTRY , 2025 (SCI-Expanded, Scopus)

2. Metabolomic signature in ocular dosing: Exploring the metabolic impacts of sublethal high-dose naringenin on ARPE-19 cells

KAPLAN O., Koc E., TÜRK S., Kucukkilinc T. T., GÖKTAŞ Z., ÇELEBİER M.

EUROPEAN JOURNAL OF INTEGRATIVE MEDICINE , cilt.72, 2024 (SCI-Expanded, Scopus)

3. 4-{3-[(Pyridin-4-ylmethyl)amino]-[1,2,4]triazolo[4,3-b][1,2,4]triazin-6-yl}phenol: An improved anticancer agent in hepatocellular carcinoma and a selective MDR1/MRP modulator

Khatir Z. Z., Di Sotto A., Percaccio E., TÜYLÜ KÜÇÜKKILINÇ Z. T., ERCAN A., Chippindale A. M., et al.

Archiv der Pharmazie , 2024 (SCI-Expanded, Scopus)

4. Phenelzine protects against acetaminophen induced apoptosis in HepG2 cells

TÜYLÜ KÜÇÜKKILINÇ Z. T., ERCAN A.

Drug and Chemical Toxicology , cilt.47, sa.1, ss.81-89, 2024 (SCI-Expanded, Scopus)

5. Novel indanone-chalcone esters with potential anti-Alzheimer effects designed using hybridization and bioisosteric replacement approaches

Azimian F., Shahrivar-Gargari M., Vahedpour T., Hemmati S., Dastmalchi M., TÜYLÜ KÜÇÜKKILINÇ Z. T., et al.

Medicinal Chemistry Research , cilt.32, sa.8, ss.1701-1712, 2023 (SCI-Expanded, Scopus)

6. Novel benzofurane carbonyl analogs of donepezil as acetylcholinesterase inhibitors

Sahin Z., Biltekin S. N., YURTTAŞ L., BERK B., Kucukkilinc T. T., DEMİRAYAK Ş.

JOURNAL OF MOLECULAR STRUCTURE , cilt.1264, 2022 (SCI-Expanded, Scopus)

7. Combined effect of fulvestrant and low dose BPA: comparative implications on EMT, apoptosis, and TGF-beta 1 signaling in HepG2 cells

Oz E., Kucukkilinc T. T.

DRUG AND CHEMICAL TOXICOLOGY , cilt.45, sa.5, ss.2285-2291, 2022 (SCI-Expanded, Scopus) Sürdürülebilir Kalkınma

8. Novel Coumarin-Pyridine Hybrids as Potent Multi-Target Directed Ligands Aiming at Symptoms of Alzheimer's Disease

Babaei E., Kucukkilinc T. T., Jalili-Baleh L., Nadri H., Oz E., Forootanfar H., et al.

FRONTIERS IN CHEMISTRY , cilt.10, 2022 (SCI-Expanded, Scopus)

9. In Vitro and In Silico Determination of Some N-ferrocenylmethylaniline Derivatives as Anti-Proliferative agents Against MCF-7 Human Breast Cancer Cell Lines

Zegheb N., Boubekri C., Lanez T., Lanez E., Kucukkilinc T. T., Oz E., et al.

ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY , cilt.22, sa.7, ss.1426-1437, 2022 (SCI-Expanded, Scopus) Sürdürülebilir Kalkınma

10. Downregulation of aromatase by siRNA decreases acetylcholinesterase mRNA and specific activity in SH-SY5Y cells

TÜYLÜ KÜÇÜKKILINÇ Z. T.

Journal of Research in Pharmacy , cilt.26, sa.2, ss.362-369, 2022 (Scopus, TRDizin)

11. Current Approaches in Breast Cancer Treatment Meme Kanseri Tedavisindeki Güncel Yaklaşımlar

Sert P. İ., TÜYLÜ KÜÇÜKKILINÇ Z. T.

Hacettepe University Journal of the Faculty of Pharmacy , cilt.42, sa.1, ss.46-59, 2022 (Scopus)

12. Synthesis of New 3-Arylcoumarins Bearing N-Benzyl Triazole Moiety: Dual Lipoxygenase and Butyrylcholinesterase Inhibitors With Anti-Amyloid Aggregation and Neuroprotective Properties Against Alzheimer's Disease

Pourabdi L., Kuecuekkilinc T. T., Khoshtale F., Ayazgoek B., Nadri H., Farokhi Alashti F., et al.

FRONTIERS IN CHEMISTRY , cilt.9, 2022 (SCI-Expanded, Scopus)

13. Hybridization-based design of novel anticholinesterase indanone-carbamates for Alzheimer's disease: Synthesis, biological evaluation, and docking studies

Shahrivar-Gargari M., Hamzeh-Mivehroud M., Hemmati S., Mojarrad J. S., TÜYLÜ KÜÇÜKKILINÇ Z. T., AYAZGÖK B., et al.

ARCHIV DER PHARMAZIE , cilt.354, sa.7, 2021 (SCI-Expanded, Scopus)

14. Chromone-lipoic acid conjugate: Neuroprotective agent having acceptable butyrylcholinesterase inhibition, antioxidant and copper-chelation activities

Jalili-Baleh L., Nadri H., Forootanfar H., Kucukkilinc T. T., AYAZGÖK B., Sharifzadeh M., et al.

DARU-JOURNAL OF PHARMACEUTICAL SCIENCES , cilt.29, sa.1, ss.23-38, 2021 (SCI-Expanded, Scopus)

15. Design, synthesis, and biological evaluation of novel indanone-based hybrids as multifunctional cholinesterase inhibitors for Alzheimer's disease

Shahrivar-Gargari M., Hamzeh-Mivehroud M., Hemmati S., Shahbazi Mojarrad J., Notash B., Tüylü Küçükkılınç T., et al.

Journal of Molecular Structure , cilt.1229, 2021 (SCI-Expanded, Scopus)

16. A review: Biologically active 3,4-heterocycle-fused coumarins

Salehian F., Nadri H., Jalili-Baleh L., Youseftabar-Miri L., Abbas Bukhari S. N., Foroumadi A., et al.

European Journal of Medicinal Chemistry , cilt.212, 2021 (SCI-Expanded, Scopus)

17. Current Approaches in Alzheimer’s Disease Treatment Alzheimer Hastalığı Tedavisindeki Güncel Yaklaşımlar

Odabaşı M. D., TÜYLÜ KÜÇÜKKILINÇ Z. T.

Hacettepe University Journal of the Faculty of Pharmacy , cilt.41, sa.4, ss.266-280, 2021 (Scopus)

18. Highly fluorinated graphene oxide nanosheets for anticancer linoleic-curcumin conjugate delivery and T2-Weighted magnetic resonance imaging: In vitro and in vivo studies

Razaghi M., Ramazani A., Khoobi M., Mortezazadeh T., AKSOY E. A., Küçükkılınç T. T.

Journal of Drug Delivery Science and Technology , cilt.60, 2020 (SCI-Expanded, Scopus) Sürdürülebilir Kalkınma

19. The role of folate metabolism in neurodegenerative diseases Folat Metabolizmasının Nörodejeneratif Hastalıklardaki Rolü

İŞbi̇Len N., Tüylü Küçükkilinç T.

Fabad Journal of Pharmaceutical Sciences , cilt.45, sa.3, ss.243-252, 2020 (Scopus, TRDizin) Sürdürülebilir Kalkınma

20. New classes of carbazoles as potential multi-functional anti-Alzheimer's agents

Choubdar N., Golshani M., Jalili-Baleh L., Nadri H., Küçükkilinç T., Ayazgök B., et al.

Bioorganic Chemistry , cilt.91, 2019 (SCI-Expanded, Scopus)

21. Design, synthesis and biological activity of novel tacrine-isatin Schiff base hybrid derivatives

Riazimontazer E., Sadeghpour H., Nadri H., Sakhteman A., Tüylü Küçükkılınç T., Miri R., et al.

Bioorganic Chemistry , cilt.89, 2019 (SCI-Expanded, Scopus)

22. Design and Synthesis of 2-Substitutedphenyl Benzo[D]Thiazole Derivatives and Their β-Amyloid Aggregation and Cholinesterase Inhibitory Activities

ZENGİN M., Unsal-Tan O., Küçükkılınç T. T., AYAZGÖK B., BALKAN A.

Pharmaceutical Chemistry Journal , cilt.53, sa.4, ss.322-328, 2019 (SCI-Expanded, Scopus)

23. Synthesis and biological assessment of 2-hydroxyiminoethanones as anti-inflammatory and β-amyloid aggregation inhibitors

Valipour M., Davaji I., Abedi N., Rajabi M., Kucukkilinc T. T., AYAZGÖK B., et al.

Iranian Journal of Pharmaceutical Research , cilt.18, sa.3, ss.1288-1298, 2019 (SCI-Expanded, Scopus)

24. 3-Aryl Coumarin Derivatives Bearing Aminoalkoxy Moiety as Multi-Target-Directed Ligands against Alzheimer's Disease

Abdshahzadeh H., Golshani M., Nadri H., Kia I. S., Abdolahi Z., Forootanfar H., et al.

Chemistry and Biodiversity , cilt.16, sa.5, 2019 (SCI-Expanded, Scopus)

25. Synthesis and biological evaluation of new N-benzylpyridinium-based benzoheterocycles as potential anti-Alzheimer's agents

Salehi N., Mirjalili B. B. F., Nadri H., Abdolahi Z., Forootanfar H., Samzadeh-Kermani A., et al.

Bioorganic Chemistry , cilt.83, ss.559-568, 2019 (SCI-Expanded, Scopus)

26. Synthesis and anticancer activity of benzimidazole/benzoxazole substituted triazolotriazines in hepatocellular carcinoma

Dadashpour S., Küçükkılınç T. T., ERCAN A., Hosseinimehr S. J., Naderi N., Irannejad H.

Anti-Cancer Agents in Medicinal Chemistry , cilt.19, sa.17, ss.2120-2129, 2019 (SCI-Expanded, Scopus)

27. Synthesis, molecular docking, and biological evaluation of novel 2-pyrazoline derivatives as multifunctional agents for the treatment of Alzheimer's disease

Unsal-Tan O., Kuecuekkilinc T. T., AYAZGÖK B., BALKAN A., Ozadali-Sari K.

MedChemComm , cilt.10, sa.6, ss.1018-1026, 2019 (SCI-Expanded, Scopus)

28. Neurotoxic effects of bisphenol a on SH-SY5Y neuroblastoma cells via nitric oxide

AYAZGÖK B., Tuylu Kucukkilinc T.

Marmara Pharmaceutical Journal , cilt.23, sa.3, ss.354-359, 2019 (SCI-Expanded, Scopus)

29. Low-dose bisphenol A induces RIPK1-mediated necroptosis in SH-SY5Y cells: Effects on TNF-α and acetylcholinesterase

Ayazgoek B., Kucukkilinc T. T.

Journal of Biochemical and Molecular Toxicology , cilt.33, sa.1, 2019 (SCI-Expanded, Scopus)

30. Discovery of novel 1,2,4-triazolo-1,2,4-triazines with thiomethylpyridine hinge binders as potent c-Met kinase inhibitors

Dadashpour S., Kϋçϋkkılınç T., Ayazgök B., Hosseinimehr S., Chippindale A., Foroumadi A., et al.

Future Medicinal Chemistry , cilt.11, sa.10, ss.1119-1136, 2019 (SCI-Expanded, Scopus)

31. Synthesis and cholinesterase inhibitory activity of new 2-benzofuran carboxamide-benzylpyridinum salts

Abedinifar F., Farnia S. M. F., Mahdavi M., Nadri H., Moradi A., Ghasemi J. B., et al.

Bioorganic Chemistry , cilt.80, ss.180-188, 2018 (SCI-Expanded, Scopus)

32. Novel 3-phenylcoumarin–lipoic acid conjugates as multi-functional agents for potential treatment of Alzheimer's disease

Jalili-Baleh L., Nadri H., Forootanfar H., Samzadeh-Kermani A., Kucukkilinc T. T., AYAZGÖK B., et al.

Bioorganic Chemistry , cilt.79, ss.223-234, 2018 (SCI-Expanded, Scopus)

33. Design, synthesis and evaluation of novel multi-target-directed ligands for treatment of Alzheimer's disease based on coumarin and lipoic acid scaffolds

Jalili-Baleh L., Forootanfar H., Kucukkilinc T. T., Nadri H., Abdolahi Z., Ameri A., et al.

European Journal of Medicinal Chemistry , cilt.152, ss.600-614, 2018 (SCI-Expanded, Scopus)

34. Synthesis and neuroprotective activity of novel 1,2,4-triazine derivatives with ethyl acetate moiety against H2O2 and Aβ-induced neurotoxicity

Kucukkilinc T. T., Yanghagh K. S., AYAZGÖK B., Roknipour M. A., Moghadam F. H., Moradi A., et al.

Medicinal Chemistry Research , cilt.26, sa.11, ss.3057-3071, 2017 (SCI-Expanded, Scopus)

35. Novel 2-Arylbenzimidazole derivatives as multi-targeting agents to treat Alzheimer’s disease

Unsal-Tan O., Ozadali-Sari K., AYAZGÖK B., Küçükkılınç T. T., BALKAN A.

Medicinal Chemistry Research , cilt.26, sa.7, ss.1506-1515, 2017 (SCI-Expanded, Scopus)

36. Novel multi-targeted agents for Alzheimer's disease: Synthesis, biological evaluation, and molecular modeling of novel 2-[4-(4-substitutedpiperazin-1-yl)phenyl]benzimidazoles

Ozadali-Sari K., Tüylü Küçükkılınç T., AYAZGÖK B., BALKAN A., Unsal-Tan O.

Bioorganic Chemistry , cilt.72, ss.208-214, 2017 (SCI-Expanded, Scopus)

37. Big Effects of Low Dose Bisphenol A

Ayazgök B., Tüylü Küçükkılınç Z. T.

Fabad Journal of Pharmaceutical Sciences , cilt.42, sa.2, ss.139-150, 2017 (Scopus)

38. Adsorption of plasma proteins on multi layer surface modified polyurethane films

AKSOY E. A., KARA F., TÜYLÜ KÜÇÜKKILINÇ Z. T., AKSOY S., HASIRCI N.

Frontiers in Bioengineering and Biotechnology , cilt.4, 2016 (Scopus)

39. 1,2-Diaryl-2-hydroxyiminoethanones as Dual COX-1 and beta-Amyloid Aggregation Inhibitors: Biological Evaluation and In Silico Study

IRANNEJAD H., Tan O., Ozadali K., DADASHPOUR S., Kucukkilinc T. T., AHANGAR N., et al.

CHEMICAL BIOLOGY & DRUG DESIGN , cilt.85, sa.4, ss.494-503, 2015 (SCI-Expanded, Scopus)

40. Design, Synthesis and In Vitro Study of 5,6-Diaryl-1,2,4-triazine-3-ylthioacetate Derivatives as COX-2 and beta-Amyloid Aggregation Inhibitors

DADASHPOUR S., Kucukkilinc T. T., Tan O., Ozadali K., IRANNEJAD H., EMAMI S.

ARCHIV DER PHARMAZIE , cilt.348, sa.3, ss.179-187, 2015 (SCI-Expanded, Scopus)

41. Potential use of acetylcholinesterase as a bioscavenger in organophasphate poisoning

Kucukkilinc T. T.

TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI , cilt.39, sa.2, ss.126-131, 2014 (SCI-Expanded, Scopus, TRDizin)

42. Synthesis, molecular modeling and evaluation of novel N '-2-(4-benzylpiperidin-/piperazin-1-yl)acylhydrazone derivatives as dual inhibitors for cholinesterases and A beta aggregation

Ozer E. O., TAN O., Ozadali K., KUCUKKILINC T., BALKAN A., UÇAR G.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS , cilt.23, sa.2, ss.440-443, 2013 (SCI-Expanded, Scopus)

43. Oxime-assisted Acetylcholinesterase Catalytic Scavengers of Organophosphates That Resist Aging

COCHRAN R., KALISIAK J., KUECUEKKILINC T., RADIC Z., GARCIA E., ZHANG L., et al.

JOURNAL OF BIOLOGICAL CHEMISTRY , cilt.286, sa.34, ss.29718-29724, 2011 (SCI-Expanded, Scopus)

44. Investigating the structural influence of surface mutations on acetylcholinesterase inhibition by organophosphorus compounds and oxime reactivation

Kucukkilinc T., Cochran R., Kalisiak J., Garcia E., Valle A., Amitai G., et al.

CHEMICO-BIOLOGICAL INTERACTIONS , cilt.187, ss.238-240, 2010 (SCI-Expanded, Scopus)

45. Inhibition of electric eel acetylcholinesterase by triarylmethane dyes

Kucukkilinc T. T., Ozer I.

CHEMICO-BIOLOGICAL INTERACTIONS , cilt.175, ss.309-311, 2008 (SCI-Expanded, Scopus)

46. Multi-site inhibition of human plasma cholinesterase by cationic phenoxazine and phenothiazine dyes

Kucukkilinc T., Ozer I.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS , cilt.461, sa.2, ss.294-298, 2007 (SCI-Expanded, Scopus)

47. Inhibition of human plasma cholinesterase by malachite green and related triarylmethane dyes: Mechanistic implications

KUCUKKILINC T., Ozer I.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS , cilt.440, sa.2, ss.118-122, 2005 (SCI-Expanded, Scopus)

Hakemli Bilimsel Toplantılarda Yayımlanmış Bildiriler 24

1. Studies on Some Benzothiazole Derivatives

ZENGİN M., BALKAN A., ÜNSAL TAN O., TÜYLÜ KÜÇÜKKILINÇ Z. T., AYAZGÖK B.

12. International Symposium on Pharmaceutical Sciences, ISOPS, Ankara, Türkiye, 26 - 29 Haziran 2018, (Tam Metin Bildiri)

2. Synthesis and Evaluation of Benzimidazole and 2-pyrazoline Derivatives as Multi-Target-Directed Ligands against Alzheimer’s Disease

ÜNSAL TAN O., ÖZADALI SARI K., AYAZGÖK B., TÜYLÜ KÜÇÜKKILINÇ Z. T., BALKAN A.

12. International Symposium on Pharmaceutical Sciences, ISOPS, Ankara, Türkiye, 26 - 29 Haziran 2018, (Tam Metin Bildiri)

3. N-ACETYL DERIVATIVES OF 2-PYRAZOLINES AS POTENT MULTI-TARGETING AGENTS FOR ALZHEIMER’S DISEASE

ÖZADALI SARI K., TÜYLÜ KÜÇÜKKILINÇ Z. T., AYAZGÖK B., BALKAN A., ÜNSAL TAN O.

2nd International Gazi Pharma Symposium Series, 11 - 13 Ekim 2017, (Özet Bildiri)

4. 4,5-dihydro-1h-pyrazoles as cholinesterase and AB aggregation inhibitors for Alzheimer’xxs disease

TÜYLÜ KÜÇÜKKILINÇ Z. T., AYAZGÖK B., ÖZADALI SARI K., BALKAN A., ÜNSAL TAN O.

Uluslararası Biyokimya Kongresi 2017- 28. Ulusal Biyokimya kongresi, 19 - 23 Eylül 2017, (Özet Bildiri)

5. Necroptotic effects of Bisphenol A on SHSY-5Y neuroblastoma cells

Ayazgök B., Tüylü Küçükkılınç Z. T.

28. Ulusal biyokimya Kongresi, Erzurum, Türkiye, 19 - 23 Eylül 2017, (Özet Bildiri)

6. Bisfenol A ’xxnın SH-SY5Y Nöroblastoma Hücrelerindeki Nekroptotik Etkisi

AYAZGÖK B., TÜYLÜ KÜÇÜKKILINÇ Z. T.

28. Uluslararası Biyokimya Kongresi, 19 - 23 Eylül 2017, (Özet Bildiri)

7. 4,5-dihydro-1h-pyrazoles as cholinesterase and Aβ aggregation inhibitors for Alzheimer’s disease

TÜYLÜ KÜÇÜKKILINÇ Z. T., AYAZGÖK B., ÖZADALI SARI K., BALKAN A., ÜNSAL TAN O.

28. Ulusal biyokimya Kongresi, Erzurum, Türkiye, 19 - 23 Eylül 2017, (Özet Bildiri)

8. Alzheimer hastalığı’nın tedavisinde çoklu hedefe yönelik ilaç tasarımı

TÜYLÜ KÜÇÜKKILINÇ Z. T.

28. Ulusal biyokimya Kongresi, Erzurum, Türkiye, 19 - 23 Eylül 2017, (Özet Bildiri)

9. siRNA-mediated downregulation of aromatase decreases acetylcholinesterase specific activity and mRNA levels

Kucukkilinc T. T.

15th International Symposium on Cholinergic Mechanisms (ISCM), Marseille, Fransa, 01 Ekim 2016, cilt.142, ss.213, (Özet Bildiri)

10. Glukometre Cihazlarının Ulusal Verifikasyonu

TÜYLÜ KÜÇÜKKILINÇ Z. T., ERCAN A., TANIŞ F., UÇAR G.

İnsülin Direnci Sempozyumu, Türkiye, 22 - 23 Mart 2017, (Özet Bildiri)

11. Novel benzimidazole derivatives with multi functions on cholinesterase enzymes and neuroprotection

Ayazgök B., Tüylü Küçükkılınç Z. T., Özadalı Sarı K., Ünsal Tan O., Balkan A.

: 15th International Symposium on Cholinergic Mechanisms (ISCM), Marseille, Fransa, 16 - 20 Ekim 2016, cilt.142, ss.188, (Özet Bildiri)

12. SirnaA mediated Downregulation of Aromatase Decreases Acetylcholinesterase Specific Activity and mRNA Levels

TÜYLÜ KÜÇÜKKILINÇ Z. T.

XVth International Symposium on Cholinergic Mechanisms, 16 - 20 Ekim 2016, (Özet Bildiri)

13. Investigation of the relationship between aromatase and seladin 1 in vivo and in vitro

KARAHAN H., LÜLE S., TÜYLÜ KÜÇÜKKILINÇ Z. T., ERCAN A., KELİCEN UĞUR E. P.

SFN (Neusoscience 2014), 15 - 19 Kasım 2014

14. Effects of Bisphenol A bpa on shsy5y cells evaluatıon of nitric oxide related pathways

AYAZGÖK B., TÜYLÜ KÜÇÜKKILINÇ Z. T.

39.th FEBS Congress, 30 Ağustos - 04 Eylül 2014

15. Inhibition of butyrylcholınesterase and acetycholinesterase by Bisphenol A

AYAZGÖK B., TÜYLÜ KÜÇÜKKILINÇ Z. T.

22nd International Congress of Clinical Chemistry and Laboratory Medicine (IFCC Worldlab 2014), 22 - 24 Haziran 2014

16. Organofosfat zehirlenmelerinde yeni bir yaklaşım katalitik biyotemizleyici asetilkolinesteraz

TÜYLÜ KÜÇÜKKILINÇ Z. T.

25. Ulusal biyokimya Kongresi, Türkiye, 3 - 06 Eylül 2013

17. Novel 2-pyrazoline derivatives bearing thiazole ring as dual monoamine oxidase-B and acetylcholinesterase inhibitors also inhibit beta-amyloid fibril

Ayazgok B., Salgin-Goksen U., Kucukkilinc T., Gokhan-Kelekci N., Ucar G.

38th Congress of the Federation-of-European-Biochemical-Societies (FEBS), Saint Peter, Guernsey Ve Alderney, 6 - 11 Temmuz 2013, cilt.280, ss.431-432, (Özet Bildiri)

18. Cholinesterase inhibition and destabilization of beta-amyloid fibriles with novel N '-2-(4-Benzylpiperidin-/piperazin-1-yl) acylhydrazone derivatives

Ozer E. O., Tan O. U., Kucukkilinc T., Ozadali K., Balkan A., Ucar G.

22nd IUBMB Congress/37th FEBS Congress, Sevilla, İspanya, 4 - 09 Eylül 2012, cilt.279, ss.363-364, (Özet Bildiri)

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