Chromone-lipoic acid conjugate: Neuroprotective agent having acceptable butyrylcholinesterase inhibition, antioxidant and copper-chelation activities


Jalili-Baleh L., Nadri H., Forootanfar H., Kucukkilinc T. T. , AYAZGÖK B. , Sharifzadeh M., ...Daha Fazla

DARU-JOURNAL OF PHARMACEUTICAL SCIENCES, 2021 (SCI İndekslerine Giren Dergi) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası:
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1007/s40199-020-00378-1
  • Dergi Adı: DARU-JOURNAL OF PHARMACEUTICAL SCIENCES

Özet

Purpose Alzheimer's disease (AD) is a multifaceted neurodegenerative disease. To target simultaneously multiple pathological processes involved in AD, natural-origin compounds with unique characteristics are promising scaffolds to develop novel multi-target compounds in the treatment of different neurodegenerative disease, especially AD. In this study, novel chromone-lipoic acid hybrids were prepared to find a new multifunctional lead structure for the treatment of AD.