© 2020 Society of Pharmaceutical Sciences of Ankara (FABAD). All rights reserved.Neurodegenerative diseases are progressive diseases, affecting many people in today. Due to unknown underlying mechanisms, many studies have been carried out about this subject. in this review, folate's role and mechanism of action on the these diseases were investigated. Folate takes place in the single carbon cycle that is necessary for vital methylation reactions in the body and its deficiency causes neurological results has provided connection with neurodegenerative diseases. in many studies, individuals with neurodegenerative diseases have high level of homocysteine level due to low folate level, have been attracteed attention. studies have shown that folate metabolism doesn't have ability to directly generate neurodegenerative diseases, but it pave the way for it's formation and enables it to progress. in this review, it is aimed to explain folate metabolism and it's role in the pathogenesis of neurodegenerative diseases.