Prof. ZEKİYE TUBA TÜYLÜ KÜÇÜKKILINÇ

Publication Network

Published journal articles indexed by SCI, SSCI, and AHCI

Novel benzofurane carbonyl analogs of donepezil as acetylcholinesterase inhibitors

Sahin Z., Biltekin S. N., YURTTAŞ L., BERK B., Kucukkilinc T. T., DEMİRAYAK Ş.

JOURNAL OF MOLECULAR STRUCTURE, vol.1264, 2022 (SCI-Expanded)

Combined effect of fulvestrant and low dose BPA: comparative implications on EMT, apoptosis, and TGF-beta 1 signaling in HepG2 cells

Oz E., Kucukkilinc T. T.

DRUG AND CHEMICAL TOXICOLOGY, vol.45, no.5, pp.2285-2291, 2022 (SCI-Expanded) Sustainable Development

Novel Coumarin-Pyridine Hybrids as Potent Multi-Target Directed Ligands Aiming at Symptoms of Alzheimer's Disease

Babaei E., Kucukkilinc T. T., Jalili-Baleh L., Nadri H., Oz E., Forootanfar H., et al.

FRONTIERS IN CHEMISTRY, vol.10, 2022 (SCI-Expanded)

In Vitro and In Silico Determination of Some N-ferrocenylmethylaniline Derivatives as Anti-Proliferative agents Against MCF-7 Human Breast Cancer Cell Lines

Zegheb N., Boubekri C., Lanez T., Lanez E., Kucukkilinc T. T., Oz E., et al.

ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, vol.22, no.7, pp.1426-1437, 2022 (SCI-Expanded) Sustainable Development

Synthesis of New 3-Arylcoumarins Bearing N-Benzyl Triazole Moiety: Dual Lipoxygenase and Butyrylcholinesterase Inhibitors With Anti-Amyloid Aggregation and Neuroprotective Properties Against Alzheimer's Disease

Pourabdi L., Kuecuekkilinc T. T., Khoshtale F., Ayazgoek B., Nadri H., Farokhi Alashti F., et al.

FRONTIERS IN CHEMISTRY, vol.9, 2022 (SCI-Expanded)

Hybridization-based design of novel anticholinesterase indanone-carbamates for Alzheimer's disease: Synthesis, biological evaluation, and docking studies

Shahrivar-Gargari M., Hamzeh-Mivehroud M., Hemmati S., Mojarrad J. S., TÜYLÜ KÜÇÜKKILINÇ Z. T., AYAZGÖK B., et al.

ARCHIV DER PHARMAZIE, vol.354, no.7, 2021 (SCI-Expanded)

Chromone-lipoic acid conjugate: Neuroprotective agent having acceptable butyrylcholinesterase inhibition, antioxidant and copper-chelation activities

Jalili-Baleh L., Nadri H., Forootanfar H., Kucukkilinc T. T., AYAZGÖK B., Sharifzadeh M., et al.

DARU-JOURNAL OF PHARMACEUTICAL SCIENCES, vol.29, no.1, pp.23-38, 2021 (SCI-Expanded)

Design, synthesis, and biological evaluation of novel indanone-based hybrids as multifunctional cholinesterase inhibitors for Alzheimer's disease

Shahrivar-Gargari M., Hamzeh-Mivehroud M., Hemmati S., Shahbazi Mojarrad J., Notash B., Tüylü Küçükkılınç T., et al.

Journal of Molecular Structure, vol.1229, 2021 (SCI-Expanded)

A review: Biologically active 3,4-heterocycle-fused coumarins

Salehian F., Nadri H., Jalili-Baleh L., Youseftabar-Miri L., Abbas Bukhari S. N., Foroumadi A., et al.

European Journal of Medicinal Chemistry, vol.212, 2021 (SCI-Expanded)

Highly fluorinated graphene oxide nanosheets for anticancer linoleic-curcumin conjugate delivery and T2-Weighted magnetic resonance imaging: In vitro and in vivo studies

Razaghi M., Ramazani A., Khoobi M., Mortezazadeh T., AKSOY E. A., Küçükkılınç T. T.

Journal of Drug Delivery Science and Technology, vol.60, 2020 (SCI-Expanded) Sustainable Development

New classes of carbazoles as potential multi-functional anti-Alzheimer's agents

Choubdar N., Golshani M., Jalili-Baleh L., Nadri H., Küçükkilinç T., Ayazgök B., et al.

Bioorganic Chemistry, vol.91, 2019 (SCI-Expanded)

Design, synthesis and biological activity of novel tacrine-isatin Schiff base hybrid derivatives

Riazimontazer E., Sadeghpour H., Nadri H., Sakhteman A., Tüylü Küçükkılınç T., Miri R., et al.

Bioorganic Chemistry, vol.89, 2019 (SCI-Expanded)

Design and Synthesis of 2-Substitutedphenyl Benzo[D]Thiazole Derivatives and Their β-Amyloid Aggregation and Cholinesterase Inhibitory Activities

ZENGİN M., Unsal-Tan O., Küçükkılınç T. T., AYAZGÖK B., BALKAN A.

Pharmaceutical Chemistry Journal, vol.53, no.4, pp.322-328, 2019 (SCI-Expanded)

Synthesis and biological assessment of 2-hydroxyiminoethanones as anti-inflammatory and β-amyloid aggregation inhibitors

Valipour M., Davaji I., Abedi N., Rajabi M., Kucukkilinc T. T., AYAZGÖK B., et al.

Iranian Journal of Pharmaceutical Research, vol.18, no.3, pp.1288-1298, 2019 (SCI-Expanded)

3-Aryl Coumarin Derivatives Bearing Aminoalkoxy Moiety as Multi-Target-Directed Ligands against Alzheimer's Disease

Abdshahzadeh H., Golshani M., Nadri H., Kia I. S., Abdolahi Z., Forootanfar H., et al.

Chemistry and Biodiversity, vol.16, no.5, 2019 (SCI-Expanded)

Synthesis and biological evaluation of new N-benzylpyridinium-based benzoheterocycles as potential anti-Alzheimer's agents

Salehi N., Mirjalili B. B. F., Nadri H., Abdolahi Z., Forootanfar H., Samzadeh-Kermani A., et al.

Bioorganic Chemistry, vol.83, pp.559-568, 2019 (SCI-Expanded)

Discovery of novel 1,2,4-triazolo-1,2,4-triazines with thiomethylpyridine hinge binders as potent c-Met kinase inhibitors

Dadashpour S., Kϋçϋkkılınç T., Ayazgök B., Hosseinimehr S., Chippindale A., Foroumadi A., et al.

Future Medicinal Chemistry, vol.11, no.10, pp.1119-1136, 2019 (SCI-Expanded)

Neurotoxic effects of bisphenol a on SH-SY5Y neuroblastoma cells via nitric oxide

AYAZGÖK B., Tuylu Kucukkilinc T.

Marmara Pharmaceutical Journal, vol.23, no.3, pp.354-359, 2019 (SCI-Expanded)

Low-dose bisphenol A induces RIPK1-mediated necroptosis in SH-SY5Y cells: Effects on TNF-α and acetylcholinesterase

Ayazgoek B., Kucukkilinc T. T.

Journal of Biochemical and Molecular Toxicology, vol.33, no.1, 2019 (SCI-Expanded)

Synthesis, molecular docking, and biological evaluation of novel 2-pyrazoline derivatives as multifunctional agents for the treatment of Alzheimer's disease

Unsal-Tan O., Kuecuekkilinc T. T., AYAZGÖK B., BALKAN A., Ozadali-Sari K.

MedChemComm, vol.10, no.6, pp.1018-1026, 2019 (SCI-Expanded)

Synthesis and anticancer activity of benzimidazole/benzoxazole substituted triazolotriazines in hepatocellular carcinoma

Dadashpour S., Küçükkılınç T. T., ERCAN A., Hosseinimehr S. J., Naderi N., Irannejad H.

Anti-Cancer Agents in Medicinal Chemistry, vol.19, no.17, pp.2120-2129, 2019 (SCI-Expanded)

Synthesis and cholinesterase inhibitory activity of new 2-benzofuran carboxamide-benzylpyridinum salts

Abedinifar F., Farnia S. M. F., Mahdavi M., Nadri H., Moradi A., Ghasemi J. B., et al.

Bioorganic Chemistry, vol.80, pp.180-188, 2018 (SCI-Expanded)

Novel 3-phenylcoumarin–lipoic acid conjugates as multi-functional agents for potential treatment of Alzheimer's disease

Jalili-Baleh L., Nadri H., Forootanfar H., Samzadeh-Kermani A., Kucukkilinc T. T., AYAZGÖK B., et al.

Bioorganic Chemistry, vol.79, pp.223-234, 2018 (SCI-Expanded)

Design, synthesis and evaluation of novel multi-target-directed ligands for treatment of Alzheimer's disease based on coumarin and lipoic acid scaffolds

Jalili-Baleh L., Forootanfar H., Kucukkilinc T. T., Nadri H., Abdolahi Z., Ameri A., et al.

European Journal of Medicinal Chemistry, vol.152, pp.600-614, 2018 (SCI-Expanded)

Synthesis and neuroprotective activity of novel 1,2,4-triazine derivatives with ethyl acetate moiety against H2O2 and Aβ-induced neurotoxicity

Kucukkilinc T. T., Yanghagh K. S., AYAZGÖK B., Roknipour M. A., Moghadam F. H., Moradi A., et al.

Medicinal Chemistry Research, vol.26, no.11, pp.3057-3071, 2017 (SCI-Expanded)

Novel 2-Arylbenzimidazole derivatives as multi-targeting agents to treat Alzheimer’s disease

Unsal-Tan O., Ozadali-Sari K., AYAZGÖK B., Küçükkılınç T. T., BALKAN A.

Medicinal Chemistry Research, vol.26, no.7, pp.1506-1515, 2017 (SCI-Expanded)

Novel multi-targeted agents for Alzheimer's disease: Synthesis, biological evaluation, and molecular modeling of novel 2-[4-(4-substitutedpiperazin-1-yl)phenyl]benzimidazoles

Ozadali-Sari K., Tüylü Küçükkılınç T., AYAZGÖK B., BALKAN A., Unsal-Tan O.

Bioorganic Chemistry, vol.72, pp.208-214, 2017 (SCI-Expanded)

1,2-Diaryl-2-hydroxyiminoethanones as Dual COX-1 and beta-Amyloid Aggregation Inhibitors: Biological Evaluation and In Silico Study

IRANNEJAD H., Tan O., Ozadali K., DADASHPOUR S., Kucukkilinc T. T., AHANGAR N., et al.

CHEMICAL BIOLOGY & DRUG DESIGN, vol.85, no.4, pp.494-503, 2015 (SCI-Expanded)

Design, Synthesis and In Vitro Study of 5,6-Diaryl-1,2,4-triazine-3-ylthioacetate Derivatives as COX-2 and beta-Amyloid Aggregation Inhibitors

DADASHPOUR S., Kucukkilinc T. T., Tan O., Ozadali K., IRANNEJAD H., EMAMI S.

ARCHIV DER PHARMAZIE, vol.348, no.3, pp.179-187, 2015 (SCI-Expanded)

Potential use of acetylcholinesterase as a bioscavenger in organophasphate poisoning

Kucukkilinc T. T.

TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, vol.39, no.2, pp.126-131, 2014 (SCI-Expanded)

Synthesis, molecular modeling and evaluation of novel N '-2-(4-benzylpiperidin-/piperazin-1-yl)acylhydrazone derivatives as dual inhibitors for cholinesterases and A beta aggregation

Ozer E. O., TAN O., Ozadali K., KUCUKKILINC T., BALKAN A., UÇAR G.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol.23, no.2, pp.440-443, 2013 (SCI-Expanded)

Oxime-assisted Acetylcholinesterase Catalytic Scavengers of Organophosphates That Resist Aging

COCHRAN R., KALISIAK J., KUECUEKKILINC T., RADIC Z., GARCIA E., ZHANG L., et al.

JOURNAL OF BIOLOGICAL CHEMISTRY, vol.286, no.34, pp.29718-29724, 2011 (SCI-Expanded)

Investigating the structural influence of surface mutations on acetylcholinesterase inhibition by organophosphorus compounds and oxime reactivation

Kucukkilinc T., Cochran R., Kalisiak J., Garcia E., Valle A., Amitai G., et al.

CHEMICO-BIOLOGICAL INTERACTIONS, vol.187, pp.238-240, 2010 (SCI-Expanded)

Inhibition of electric eel acetylcholinesterase by triarylmethane dyes

Kucukkilinc T. T., Ozer I.

CHEMICO-BIOLOGICAL INTERACTIONS, vol.175, pp.309-311, 2008 (SCI-Expanded)

Multi-site inhibition of human plasma cholinesterase by cationic phenoxazine and phenothiazine dyes

Kucukkilinc T., Ozer I.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, vol.461, no.2, pp.294-298, 2007 (SCI-Expanded)

Inhibition of human plasma cholinesterase by malachite green and related triarylmethane dyes: Mechanistic implications

KUCUKKILINC T., Ozer I.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, vol.440, no.2, pp.118-122, 2005 (SCI-Expanded)

Articles Published in Other Journals

Downregulation of aromatase by siRNA decreases acetylcholinesterase mRNA and specific activity in SH-SY5Y cells

TÜYLÜ KÜÇÜKKILINÇ Z. T.

Journal of Research in Pharmacy, vol.26, no.2, pp.362-369, 2022 (Scopus)

Current Approaches in Breast Cancer Treatment Meme Kanseri Tedavisindeki Güncel Yaklaşımlar

Sert P. İ., TÜYLÜ KÜÇÜKKILINÇ Z. T.

Hacettepe University Journal of the Faculty of Pharmacy, vol.42, no.1, pp.46-59, 2022 (Scopus)

Current Approaches in Alzheimer’s Disease Treatment Alzheimer Hastalığı Tedavisindeki Güncel Yaklaşımlar

Odabaşı M. D., TÜYLÜ KÜÇÜKKILINÇ Z. T.

Hacettepe University Journal of the Faculty of Pharmacy, vol.41, no.4, pp.266-280, 2021 (Scopus)

The role of folate metabolism in neurodegenerative diseases Folat Metabolizmasının Nörodejeneratif Hastalıklardaki Rolü

İŞbi̇Len N., Tüylü Küçükkilinç T.

Fabad Journal of Pharmaceutical Sciences, vol.45, no.3, pp.243-252, 2020 (Scopus) Sustainable Development

Big Effects of Low Dose Bisphenol A

Ayazgök B., Tüylü Küçükkılınç Z. T.

Fabad Journal of Pharmaceutical Sciences, vol.42, no.2, pp.139-150, 2017 (Scopus)

Adsorption of plasma proteins on multi layer surface modified polyurethane films

AKSOY E. A., KARA F., TÜYLÜ KÜÇÜKKILINÇ Z. T., AKSOY S., HASIRCI N.

Frontiers in Bioengineering and Biotechnology, vol.4, 2016 (Scopus)

Refereed Congress / Symposium Publications in Proceedings

Studies on Some Benzothiazole Derivatives

ZENGİN M., BALKAN A., ÜNSAL TAN O., TÜYLÜ KÜÇÜKKILINÇ Z. T., AYAZGÖK B.

12. International Symposium on Pharmaceutical Sciences, ISOPS, Ankara, Turkey, 26 - 29 June 2018

Synthesis and Evaluation of Benzimidazole and 2-pyrazoline Derivatives as Multi-Target-Directed Ligands against Alzheimer’s Disease

ÜNSAL TAN O., ÖZADALI SARI K., AYAZGÖK B., TÜYLÜ KÜÇÜKKILINÇ Z. T., BALKAN A.

12. International Symposium on Pharmaceutical Sciences, ISOPS, Ankara, Turkey, 26 - 29 June 2018

N-ACETYL DERIVATIVES OF 2-PYRAZOLINES AS POTENT MULTI-TARGETING AGENTS FOR ALZHEIMER’S DISEASE

ÖZADALI SARI K., TÜYLÜ KÜÇÜKKILINÇ Z. T., AYAZGÖK B., BALKAN A., ÜNSAL TAN O.

2nd International Gazi Pharma Symposium Series, 11 - 13 October 2017

4,5-dihydro-1h-pyrazoles as cholinesterase and AB aggregation inhibitors for Alzheimer’xxs disease

TÜYLÜ KÜÇÜKKILINÇ Z. T., AYAZGÖK B., ÖZADALI SARI K., BALKAN A., ÜNSAL TAN O.

Uluslararası Biyokimya Kongresi 2017- 28. Ulusal Biyokimya kongresi, 19 - 23 September 2017

Necroptotic effects of Bisphenol A on SHSY-5Y neuroblastoma cells

Ayazgök B., Tüylü Küçükkılınç Z. T.

28. Ulusal biyokimya Kongresi, Erzurum, Turkey, 19 - 23 September 2017

Bisfenol A ’xxnın SH-SY5Y Nöroblastoma Hücrelerindeki Nekroptotik Etkisi

AYAZGÖK B., TÜYLÜ KÜÇÜKKILINÇ Z. T.

28. Uluslararası Biyokimya Kongresi, 19 - 23 September 2017

4,5-dihydro-1h-pyrazoles as cholinesterase and Aβ aggregation inhibitors for Alzheimer’s disease

TÜYLÜ KÜÇÜKKILINÇ Z. T., AYAZGÖK B., ÖZADALI SARI K., BALKAN A., ÜNSAL TAN O.

28. Ulusal biyokimya Kongresi, Erzurum, Turkey, 19 - 23 September 2017

Alzheimer hastalığı’nın tedavisinde çoklu hedefe yönelik ilaç tasarımı

TÜYLÜ KÜÇÜKKILINÇ Z. T.

28. Ulusal biyokimya Kongresi, Erzurum, Turkey, 19 - 23 September 2017

siRNA-mediated downregulation of aromatase decreases acetylcholinesterase specific activity and mRNA levels

Kucukkilinc T. T.

15th International Symposium on Cholinergic Mechanisms (ISCM), Marseille, France, 01 October 2016, vol.142, pp.213

Glukometre Cihazlarının Ulusal Verifikasyonu

TÜYLÜ KÜÇÜKKILINÇ Z. T., ERCAN A., TANIŞ F., UÇAR G.

İnsülin Direnci Sempozyumu, Turkey, 22 - 23 March 2017

Novel benzimidazole derivatives with multi functions on cholinesterase enzymes and neuroprotection

Ayazgök B., Tüylü Küçükkılınç Z. T., Özadalı Sarı K., Ünsal Tan O., Balkan A.

: 15th International Symposium on Cholinergic Mechanisms (ISCM), Marseille, France, 16 - 20 October 2016, vol.142, pp.188

SirnaA mediated Downregulation of Aromatase Decreases Acetylcholinesterase Specific Activity and mRNA Levels

TÜYLÜ KÜÇÜKKILINÇ Z. T.

XVth International Symposium on Cholinergic Mechanisms, 16 - 20 October 2016

Investigation of the relationship between aromatase and seladin 1 in vivo and in vitro

KARAHAN H., LÜLE S., TÜYLÜ KÜÇÜKKILINÇ Z. T., ERCAN A., KELİCEN UĞUR E. P.

SFN (Neusoscience 2014), 15 - 19 November 2014

Effects of Bisphenol A bpa on shsy5y cells evaluatıon of nitric oxide related pathways

AYAZGÖK B., TÜYLÜ KÜÇÜKKILINÇ Z. T.

39.th FEBS Congress, 30 August - 04 September 2014

Inhibition of butyrylcholınesterase and acetycholinesterase by Bisphenol A

AYAZGÖK B., TÜYLÜ KÜÇÜKKILINÇ Z. T.

22nd International Congress of Clinical Chemistry and Laboratory Medicine (IFCC Worldlab 2014), 22 - 24 June 2014

Organofosfat zehirlenmelerinde yeni bir yaklaşım katalitik biyotemizleyici asetilkolinesteraz

TÜYLÜ KÜÇÜKKILINÇ Z. T.

25. Ulusal biyokimya Kongresi, Turkey, 3 - 06 September 2013

Novel 2-pyrazoline derivatives bearing thiazole ring as dual monoamine oxidase-B and acetylcholinesterase inhibitors also inhibit beta-amyloid fibril

Ayazgok B., Salgin-Goksen U., Kucukkilinc T., Gokhan-Kelekci N., Ucar G.

38th Congress of the Federation-of-European-Biochemical-Societies (FEBS), Saint Peter, Guernsey And Alderney, 6 - 11 July 2013, vol.280, pp.431-432

Cholinesterase inhibition and destabilization of beta-amyloid fibriles with novel N '-2-(4-Benzylpiperidin-/piperazin-1-yl) acylhydrazone derivatives

Ozer E. O., Tan O. U., Kucukkilinc T., Ozadali K., Balkan A., Ucar G.

22nd IUBMB Congress/37th FEBS Congress, Sevilla, Spain, 4 - 09 September 2012, vol.279, pp.363-364

Publications & Works

Published journal articles indexed by SCI, SSCI, and AHCI

Articles Published in Other Journals

Refereed Congress / Symposium Publications in Proceedings