Education Information
2012 - 2016
2012 - 2016Post Doctorate
Hacettepe University, Çocuk Sağlığı Enstitüsü, Pediatrik İmmünoloji Bilim Dalı, Turkey
2008 - 2012
2008 - 2012Doctorate
Hacettepe University, Onkoloji Enstitüsü, Turkey
Dissertations
2012
2012Doctorate
MEME KANSERİNDE FOXP1'İN PI3K/AKT SİNYAL YOLAĞI TARAFINDAN DÜZENLENMESİ
Hacettepe Üniversitesi, Onkoloji Enstitüsü, Tümör Biyolojisi Ve İmmünolojisi
2008
2008Postgraduate
P53-/- ve P53 +/+ HCT116 KOLON KANSER HÜCRE SERİLERĐNDE RADYASYONUN HÜCRE
PROLİFERASYONU VE TELOMERAZ AKTİVĐTESİ ÜZERİNE ETKİSİ 
Ankara Üniversitesi, Biyoteknoloji Enstitüsü, Temel Biyoteknoloji
Foreign Languages
C1 Advanced
C1 AdvancedEnglish
Certificates, Courses and Trainings
2019
20196. Turkish-US Cytometry Workshop
Health&Medicine
İstanbul Üniversitesi
Research Areas
Medicine
Health Sciences
Fundamental Medical Sciences
Medical Biology
Life Sciences
Molecular Biology and Genetics
Genetic Disorders
Natural Sciences
Academic Titles / Tasks
2024 - Continues
2024 - ContinuesAssociate Professor
Hacettepe University, Çocuk Sağlığı Enstitüsü, Pediatrik Temel Bilimler A.B.D.
2022 - 2024
2022 - 2024Assistant Professor
Hacettepe University, Çocuk Sağlığı Enstitüsü
2018 - 2022
2018 - 2022Lecturer PhD
Hacettepe University, Çocuk Sağlığı Enstitüsü, Pediatrik İmmünoloji Bilim Dalı
2017 - 2018
2017 - 2018Researcher
Hacettepe University, Çocuk Sağlığı Enstitüsü
2016 - 2017
2016 - 2017Researcher
University of London-Kings College London, Faculty of Life Sciences and Medicine
2012 - 2016
2012 - 2016Occupational Expert
Hacettepe University, Çocuk Sağlığı Enstitüsü, Pediatrik Temel Bilimler A.B.D.
2009 - 2012
2009 - 2012Research Assistant
Hacettepe University, Kanser Enstitüsü, Temel Onkoloji A.B.D.
2009 - 2009
2009 - 2009Researcher
University of Oxford, Nuffield Department of Laboratory Sciences
Courses
Published journal articles indexed by SCI, SSCI, and AHCI
2024
2024Comparative analysis of protein expression profiles with genotypes in the diagnosis of Inborn Errors of Immunity.
Oskay Halacli S., Cagdas D. N., Esenboga S., Inan D., Yaz İ., Cicek B., et al.
Scandinavian journal of clinical and laboratory investigation
, pp.1-10, 2024 (SCI-Expanded)
2024
2024A single center experience on PI3K/AKT/MTOR signaling defects: Towards pathogenicity assessment for four novel defects.
Bildik H. N., Esenboga S., Halaclı S., Karaatmaca B., Aytekin E. S., Nabiyeva N., et al.
Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology
, vol.35, no.9, 2024 (SCI-Expanded)
2022
2022A single-center study points to diverse features and outcome in patients with Hyperimmunoglobulin M Syndrome and Class- Switch Recombination defects
Akarsu A., Halaçlı S., Tan Ç., Kuşkonmaz B., Küpesiz A., Çetinkaya D., et al.
SCANDINAVIAN JOURNAL OF IMMUNOLOGY
, vol.96, no.5, 2022 (SCI-Expanded)
2022
2022Clinical, Laboratory Features and Clinical Courses of Patients with Wiskott Aldrich Syndrome and X-linked Thrombocytopenia-A single center study.
Bildik H. N., Cagdas D. N., Ozturk Kura A., Oskay Halacli S., Sanal O., Tezcan I.
Immunological investigations
, vol.51, no.5, pp.1272-1283, 2022 (SCI-Expanded)
2022
2022The effect of mutatio-type on proteo-phenotype and clinico-phenotype in selected primary immunodeficiencies.
Halacli S.
Immunologic research
, vol.70, no.1, pp.56-66, 2022 (SCI-Expanded)
2021
2021Diversity in Serine/Threonine Protein Kinase-4 Deficiency and Review of the Literature
Cagdas D. N., Halacli S., Tan C., Esenboğa S., Karaatmaca B., Cetinkaya P. G., et al.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
, vol.9, no.10, pp.3752-3770, 2021 (SCI-Expanded)
2021
2021Clinical and laboratory findings in patients with leukocyte adhesion deficiency type I: A multicenter study in Turkey
Yaz İ., Ozbek B., Bildik H. N., Tan C., Oskay Halacli S., Soyak Aytekin E., et al.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
, vol.206, no.1, pp.47-55, 2021 (SCI-Expanded)
2021
2021The imbalance of the circulating regulatory B cell subsets in patients with primary immunodeficiencies
Halacli S., Inan D., BİLDİK H. N., AKARSU A., Kahveci M., Ozbek B., et al.
EUROPEAN JOURNAL OF IMMUNOLOGY
, vol.51, pp.83, 2021 (SCI-Expanded)
2021
2021Clinical and Immunological Characteristics of 63 Patients with Chronic Granulomatous Disease: Hacettepe Experience
Akar H. T., Esenboga S., Cagdas D. N., Halacli S., Ozbek B., van Leeuwen K., et al.
JOURNAL OF CLINICAL IMMUNOLOGY
, vol.41, no.5, pp.992-1003, 2021 (SCI-Expanded)
2020
2020Lymphocyte Subgroups and KREC Numbers in Common Variable Immunodeficiency: A Single Center Study
Yaz I., Ozbek B., Ng Y. Y., Cetinkaya P. G., Halacli S., TAN Ç., et al.
JOURNAL OF CLINICAL IMMUNOLOGY
, vol.40, no.3, pp.494-502, 2020 (SCI-Expanded)
2019
2019A Spectrum of Clinical Findings from ALPS to CVID: Several Novel LRBA Defects.
Cagdas D. N., Halaçlı S., Tan Ç., Lo B., Çetinkaya P., Esenboğa S., et al.
Journal of clinical immunology
, vol.39, no.7, pp.726-738, 2019 (SCI-Expanded)
2018
2018Expression of ADAMTS2 and ADAMTS5 in the salivary gland of rats after radioiodine therapy
Sadic M., Demirel K., OSKAY HALAÇLI S., Karakok E., Koca G., Ekinci O., et al.
NUCLEAR MEDICINE COMMUNICATIONS
, vol.39, no.2, pp.110-117, 2018 (SCI-Expanded)
2017
2017PAK5 mediates cell: cell adhesion integrity via interaction with E-cadherin in bladder cancer cells.
Ismail A., Oskay H., Babteen N., De P., Martin T., Jiang W., et al.
The Biochemical journal
, vol.474, pp.1333-1346, 2017 (SCI-Expanded)
2017
2017FOXP1 enhances tumor cell migration by repression of NFAT1 transcriptional activity in MDA-MB-231 cells
Halacli S.
CELL BIOLOGY INTERNATIONAL
, vol.41, no.1, pp.102-110, 2017 (SCI-Expanded)
2016
2016Investigation of hemophagocytic lymphohistiocytosis in severe sepsis patients.
HALACLI B., Unver N., HALACLI S., CANPINAR H., ERSOY E., OCAL S., et al.
Journal of critical care
, vol.35, pp.185-90, 2016 (SCI-Expanded)
2015
2015STK4 (MST1) deficiency in two siblings with autoimmune cytopenias: A novel mutation
HALACLI S. O., AYVAZ D. N., Sun-Tan C., Erman B., Uz E., YILMAZ D. Y., et al.
CLINICAL IMMUNOLOGY
, vol.161, no.2, pp.316-323, 2015 (SCI-Expanded)
2015
2015Interleukin-1β induced nuclear factor-κB binds to a disintegrin-like and metalloproteinase with thrombospondin type 1 motif 9 promoter in human chondrosarcoma cells.
Altuntas A., Halacli S., Cakmak O., Erden G., Akyol S., Ugurcu V., et al.
Molecular medicine reports
, vol.12, pp.595-600, 2015 (SCI-Expanded)
2015
2015FOXP1 regulation via the PI3K/Akt/p70S6K signaling pathway in breast cancer cells
Halacli S., DOĞAN A. L.
ONCOLOGY LETTERS
, vol.9, no.3, pp.1482-1488, 2015 (SCI-Expanded)
2013
2013Effects of gamma irradiation on cell cycle, apoptosis and telomerase activity in p53 wild-type and deficient HCT116 colon cancer cell lines.
Halacli S., Canpinar H., Cimen E., Sunguroglu A.
Oncology letters
, vol.6, pp.807-810, 2013 (SCI-Expanded)
2013
2013The significance of heat shock proteins in breast cancer therapy
OSKAY HALAÇLI S., HALAÇLI B., Altundag K.
MEDICAL ONCOLOGY
, vol.30, no.2, 2013 (SCI-Expanded)
2012
2012Regulation of HIF-1 alpha Expression By PI3K/Akt Pathway Inhibitors in Breast Cancer Cell Lines
DOĞAN A. L., Cimen E., Oskay S., Oksuz S., Guc D.
TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
, vol.37, no.3, pp.264-271, 2012 (SCI-Expanded)
2009
2009CONSTRUCTION OF BICISTRONIC B-GALACTOSIDASE REPORTER PLASMIDS FOR EUKARYOTIC EXPRESSION OF CD40 LIGAND (CD40L) GENE
Dolen Y., ESENDAĞLI G., Oskay S., Guc D.
IUBMB LIFE
, vol.61, no.3, pp.335, 2009 (SCI-Expanded)
Articles Published in Other Journals
2024
2024False Negative Next-Generation-Sequencing Analysis in a Lipopolysa ccharide-Responsive Beige-Like Anchor Defect.
Ünal T., Esenboğa S., Oskay Halaçlı S., Tezcan I., Çağdaş D. N.
Turkish archives of pediatrics
, vol.59, no.2, pp.221-223, 2024 (ESCI)
2021
2021Flow Cytometric Analysis of T Cell Vβ Repertoire in Common Variable Immunodeficiency Patients with TACI Mutations
OSKAY HALAÇLI S., ÖZBEK B., SOYAK AYTEKİN E., YAZ İ., TAN Ç., ÇAĞDAŞ AYVAZ D. N., et al.
TURKISH JOURNAL OF IMMUNOLOGY
, vol.9, no.1, pp.12-19, 2021 (ESCI)
2021
2021Flow Cytometric Analysis of T Cell V beta Repertoire in Common Variable Immunodeficiency Patients with TACI Mutations
OSKAY HALAÇLI S., ÖZBEK B., Aytekin E. S., YAZ İ., TAN Ç., ÇAĞDAŞ AYVAZ D. N., et al.
TURKISH JOURNAL OF IMMUNOLOGY
, vol.9, no.1, pp.12-19, 2021 (ESCI)
2020
2020Flow Cytometry is a Reliable Tool in the Diagnosis of STK4 Deficiency
Oskay Halaçlı S., Çağdaş Ayvaz D. N., Tezcan F. İ.
ASTIM ALLERJI IMMUNOLOJI
, vol.18, pp.113-117, 2020 (ESCI)
2019
2019The significance of Western Blot in Primary Immunodeficiencies: Examples from two families
Halacli S., Cagdas D. N., TEZCAN F. İ.
TURKISH JOURNAL OF IMMUNOLOGY
, vol.7, no.3, pp.120-124, 2019 (ESCI)
Papers Published in Refereed Scientific Meetings
2021
2021Primer İmmün Yetmezlik Şüpheli Hastalarda DOCK8 Protein İfadesinin İncelenmesi
İnan D., OSKAY HALAÇLI S., YAZ İ., ESENBOĞA S., ÇAĞDAŞ AYVAZ D. N., TEZCAN F. İ.
7. klinik İmmünoloji Kongresi, Turkey, 6 - 09 October 2021, vol.1, pp.90
2020
2020HOMOZİGOT VE HETEROZİGOT TACI MUTASYONU SAPTANAN PİY'Lİ HASTALARIN KLİNİK VE İMMÜNOLOJİK BULGULARININ DEĞERLENDİRİLMESİ
ÖZBEK B., YAZ İ., TAN Ç., OSKAY HALAÇLI S., SOYAK AYTEKİN E., BİLDİK H. N., et al.
6. KLİNİK İMMÜNOLOJİ KONGRESİ, Turkey, 31 October - 01 November 2020
2020
2020Primer İmmün Yetmezliklerde CFSE Hücre Proliferasyon Analizi: Referans Değerler
OSKAY HALAÇLI S., SOYAK AYTEKİN E., BİLDİK H. N., OCAK M., ÇAĞDAŞ AYVAZ D. N., TEZCAN F. İ.
6. Klinik İmmünoloji Kongresi, Online, 31 October - 01 November 2020, pp.119-120
2016
2016Lipopolisakkarit e duyarlı beige benzeri Protein LRBA Defekti Bulunan Hastaların Klinik ve Laboratuvar Bulgularının Değerlendirilmesi Hacettepe Serisi
ÇAĞDAŞ AYVAZ D. N., KARAATMACA B., ESENBOĞA S., YILMAZ T., ERMAN B., TAN Ç., et al.
2. Klinik İmmünoloji Kongresi, Turkey, 31 March - 03 April 2016
2015
2015STK 4 MST1 Deficiency in Three Families with the Clinical and Immunological Features of AR HIES
ÇAĞDAŞ AYVAZ D. N., oskay S., TAN Ç., Erman B., UZ E., ÖZGÜL R. K., et al.
International Forum on Immunology Research, 8 - 10 October 2015
2014
2014CLINICAL AND IMMUNOLOGIC FEATURES OF PATIENTS WITH THE PHENOTYPE OF AR-HIES: PATIENTS WITH AND WITHOUT DOCK8 DEFICIENCY
Sanal O., Ayvaz D. N., TAN Ç., Oskay S., Uz E., Akarsu N., et al.
100th J Project Meeting, Antalya, Turkey, 12 - 14 March 2014, vol.34, pp.746-747
Books
2021
2021Flow Cytometric Approach in the Diagnosis of Primary Immunodeficiencies
Oskay Halaçlı S.
in: Cell Interaction-Regulation of Immune Responses, Disease Development and Management Strategies, Bhawana Singh, Editor, intechopen, London, pp.1-21, 2021
Supported Projects
2023 - 2025
2023 - 2025Hiperimmünglobulin E Sendromu Tanılı hastalarda immünfenotipik değerlendirmeye ek olarak lenfoid hucre ve nötrofillerde retinoik asit ve anti-IL23 uyarımı ile ilişkili gen ekspresyon analizi
TUBITAK Project
Çağdaş Ayvaz D. N.(Executive), Peynircioğlu B., Kelicen Uğur E. P., Akkaya Ulum Z. Y., Esenboğa S., Oskay Halaçli S., et al.
Peer Reviews in Scientific Publications
January 2018
January 2018ONCOLOGY LETTERS
Journal Indexed in SCI-E
January 2018
January 2018ONCOLOGY REPORTS
Journal Indexed in SCI-E
January 2015
January 2015TUMOR BIOLOGY
Journal Indexed in SCI-E
Scientific Project Refereeing
February 2020
February 2020TUBITAK Project
1001 - Program for Supporting Scientific and Technological Research Projects, Hacettepe University, Turkey
Scholarships
2016 - 2017
2016 - 20172219- Yurt Dışı Doktora Sonrası Araştırma Bursu
TUBITAK
2006 - 2006
2006 - 2006