Flow Cytometric Analysis of T Cell V beta Repertoire in Common Variable Immunodeficiency Patients with TACI Mutations


OSKAY HALAÇLI S. , ÖZBEK B. , Aytekin E. S. , YAZ İ. , TAN Ç. , ÇAĞDAŞ AYVAZ D. N. , ...More

TURKISH JOURNAL OF IMMUNOLOGY, vol.9, no.1, pp.12-19, 2021 (Journal Indexed in ESCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 9 Issue: 1
  • Publication Date: 2021
  • Doi Number: 10.5222/tji.2021.43531
  • Title of Journal : TURKISH JOURNAL OF IMMUNOLOGY
  • Page Numbers: pp.12-19

Abstract

Objective: TCR (T Cell Receptor) which is expressed on T cells is responsible for recognizing antigens presented by HLA molecules of the APCs (Antigen Presenting Cells) and initiation of the immune response. It has been reported that TACI (Transmembrane activator and calcium modulating cyclophilin ligand interactor) mediates the interaction of B cells and dendritic cells which are both responsible for the processing of T cells.