The significance of heat shock proteins in breast cancer therapy

OSKAY HALAÇLI S., HALAÇLI B., Altundag K.

MEDICAL ONCOLOGY, cilt.30, sa.2, 2013 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 30 Sayı: 2
  • Basım Tarihi: 2013
  • Doi Numarası: 10.1007/s12032-013-0575-y
  • Dergi Adı: MEDICAL ONCOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Anahtar Kelimeler: Heat shock proteins, Breast cancer, Treatment, DRUG-RESISTANCE, DOWN-REGULATION, DNA VACCINE, PHASE-II, HSP90, EXPRESSION, HSP27, GELDANAMYCIN, CELLS, 17-ALLYLAMINO-17-DEMETHOXYGELDANAMYCIN
  • Hacettepe Üniversitesi Adresli: Evet

Özet

The evalutionary conserved heat shock proteins are involved basically life protecting mechanisms against harmful extracellular effects such as primarily heat shock response. Normally, the expression of these proteins is increased for cellular adaptation to high temperature. This increase is also important in the etiology of breast cancer. Overexpression of heat shock proteins is associated with reduced disease-free survival in breast cancer. However, increased expression of these proteins is related to acquired resistance of traditional chemotherapeutic drugs in use in breast cancer treatment. In this review, we discuss the multiple roles of heatshock proteins in resistance and where we are to overcome this in clinical practice.