Regulation of HIF-1 alpha Expression By PI3K/Akt Pathway Inhibitors in Breast Cancer Cell Lines

DOĞAN A. L., Cimen E., Oskay S., Oksuz S., Guc D.

TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, vol.37, no.3, pp.264-271, 2012 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 37 Issue: 3
  • Publication Date: 2012
  • Doi Number: 10.5505/tjb.2012.54254
  • Journal Name: TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.264-271
  • Keywords: HIF-1 alpha, PI-103, PI3K, breast cancer, EGFR PTEN, HYPOXIA-INDUCIBLE-FACTOR, PROTEIN-KINASE, MTOR, GROWTH, SUSCEPTIBILITY, ANGIOGENESIS, 3-KINASE, BIOLOGY, BINDING, AKT
  • Hacettepe University Affiliated: Yes

Abstract

Aim: The aim of this study is to compare the effect of PI-103, which is a dual PI3K/mTOR inhibitor, on MDA-MB-231 human breast cancer cell line that has an intact PI3K/Akt pathway with MDA-MB-468 cells defected in this pathway (EGFR amplification and PTEN mutation) and also to compare the effect of PI-103, to Wortmannin, which is a PI3K inhibitor, by determining the regulatory role of this inhibition on HIF-1 alpha expression.