Regulation of HIF-1 alpha Expression By PI3K/Akt Pathway Inhibitors in Breast Cancer Cell Lines

DOĞAN A. L., Cimen E., Oskay S., Oksuz S., Guc D.

TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, cilt.37, sa.3, ss.264-271, 2012 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 37 Sayı: 3
  • Basım Tarihi: 2012
  • Doi Numarası: 10.5505/tjb.2012.54254
  • Dergi Adı: TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.264-271
  • Anahtar Kelimeler: HIF-1 alpha, PI-103, PI3K, breast cancer, EGFR PTEN, HYPOXIA-INDUCIBLE-FACTOR, PROTEIN-KINASE, MTOR, GROWTH, SUSCEPTIBILITY, ANGIOGENESIS, 3-KINASE, BIOLOGY, BINDING, AKT
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Aim: The aim of this study is to compare the effect of PI-103, which is a dual PI3K/mTOR inhibitor, on MDA-MB-231 human breast cancer cell line that has an intact PI3K/Akt pathway with MDA-MB-468 cells defected in this pathway (EGFR amplification and PTEN mutation) and also to compare the effect of PI-103, to Wortmannin, which is a PI3K inhibitor, by determining the regulatory role of this inhibition on HIF-1 alpha expression.