TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, vol.37, no.3, pp.264-271, 2012 (Journal Indexed in SCI)
Article / Article
Title of Journal :
TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
HIF-1 alpha, PI-103, PI3K, breast cancer, EGFR PTEN, HYPOXIA-INDUCIBLE-FACTOR, PROTEIN-KINASE, MTOR, GROWTH, SUSCEPTIBILITY, ANGIOGENESIS, 3-KINASE, BIOLOGY, BINDING, AKT
Aim: The aim of this study is to compare the effect of PI-103, which is a dual PI3K/mTOR inhibitor, on MDA-MB-231 human breast cancer cell line that has an intact PI3K/Akt pathway with MDA-MB-468 cells defected in this pathway (EGFR amplification and PTEN mutation) and also to compare the effect of PI-103, to Wortmannin, which is a PI3K inhibitor, by determining the regulatory role of this inhibition on HIF-1 alpha expression.