Flow Cytometric Analysis of T Cell Vβ Repertoire in Common Variable Immunodeficiency Patients with TACI Mutations

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OSKAY HALAÇLI S., ÖZBEK B., SOYAK AYTEKİN E., YAZ İ., TAN Ç., ÇAĞDAŞ AYVAZ D. N., ...More

TURKISH JOURNAL OF IMMUNOLOGY, vol.9, no.1, pp.12-19, 2021 (ESCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 9 Issue: 1
  • Publication Date: 2021
  • Doi Number: 10.5222/tji.2021.43531
  • Journal Name: TURKISH JOURNAL OF IMMUNOLOGY
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, Academic Search Premier, EMBASE, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.12-19
  • Keywords: TACI, CVID, primary immunodeficiency, TCRV beta repertory, ACTIVATING FACTOR, DISEASE, METHODOLOGIES, RECEPTORS, MODEL, BAFF
  • Hacettepe University Affiliated: Yes

Abstract

Objective: TCR (T Cell Receptor) which is expressed on T cells is responsible for recognizing antigens presented by HLA molecules of the APCs (Antigen Presenting Cells) and initiation of the immune response. It has been reported that TACI (Transmembrane activator and calcium modulating cyclophilin ligand interactor) mediates the interaction of B cells and dendritic cells which are both responsible for the processing of T cells.