Flow Cytometric Analysis of T Cell Vβ Repertoire in Common Variable Immunodeficiency Patients with TACI Mutations

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OSKAY HALAÇLI S., ÖZBEK B., SOYAK AYTEKİN E., YAZ İ., TAN Ç., ÇAĞDAŞ AYVAZ D. N., ...Daha Fazla

TURKISH JOURNAL OF IMMUNOLOGY, cilt.9, sa.1, ss.12-19, 2021 (ESCI) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 9 Sayı: 1
  • Basım Tarihi: 2021
  • Doi Numarası: 10.5222/tji.2021.43531
  • Dergi Adı: TURKISH JOURNAL OF IMMUNOLOGY
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, Academic Search Premier, EMBASE, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.12-19
  • Anahtar Kelimeler: TACI, CVID, primary immunodeficiency, TCRV beta repertory, ACTIVATING FACTOR, DISEASE, METHODOLOGIES, RECEPTORS, MODEL, BAFF
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Objective: TCR (T Cell Receptor) which is expressed on T cells is responsible for recognizing antigens presented by HLA molecules of the APCs (Antigen Presenting Cells) and initiation of the immune response. It has been reported that TACI (Transmembrane activator and calcium modulating cyclophilin ligand interactor) mediates the interaction of B cells and dendritic cells which are both responsible for the processing of T cells.