Metrikler
Yayın
41
Açık Erişim
6
BM Sürdürülebilir Kalkınma Amaçları
Eğitim Bilgileri
2004 - 2009
2004 - 2009Doktora
Hacettepe Üniversitesi, Sağlık Bilimleri Enstitüsü, Farmasötik Kimya Anabilimdalı, Türkiye
Yaptığı Tezler
2009
2009Doktora
Yeni Bazı İzoksazolo[4,5-d]piridazin-4(5H)-on Türevlerinin Sentezi ve Farmakolojik Etkilerinin Araştırılması
Hacettepe Üniversitesi, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümü
2004
2004Yüksek Lisans
Bazı 5-Benziliden-6-metil-3(4H)-piridazinon Türevleri Üzerinde Çalışmalar
Hacettepe Üniversitesi, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümü
Yabancı Diller
B2 Orta Üstü
B2 Orta Üstüİngilizce
Araştırma Alanları
Sağlık Bilimleri
Eczacılık
Meslek Bilimleri
Farmasötik Kimya
Akademik Faaliyetlere Dayalı Araştırma Alanları
Avesis Araştırma Alanları
WoS Araştırma Alanları
Scopus Araştırma Alanları
Akademik Ünvanlar / Görevler
2009 - 2013
2009 - 2013Öğretim Görevlisi Dr.
Hacettepe Üniversitesi, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümü
2002 - 2009
2002 - 2009Araştırma Görevlisi
Hacettepe Üniversitesi, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümü
Akademi Dışı Deneyim
2007 - 2008
2007 - 2008Misafir araştırmacı
University of Calgary, Misafir araştırmacı
Makaleler
Tümü (34)
SCI-E, SSCI, AHCI (33)
SCI-E, SSCI, AHCI, ESCI (34)
ESCI (1)
Scopus (34)
TRDizin (4)
2025
20251. Promising Antimycobacterial Agents: Salicylidenehydrazines
ÜNSAL TAN O., Vagolu S. K., Tonjum T., KAPLAN O., ŞİMŞEK R.
ARCHIV DER PHARMAZIE
, cilt.358, sa.7, 2025 (SCI-Expanded, Scopus)
2024
20242. Design and Discovery of New Dual Carbonic Anhydrase IX and VEGFR-2 Inhibitors Based on the Benzenesulfonamide-Bearing 4-Thiazolidinones/2,4-Thiazolidinediones Scaffold
ZENGİN M., ÜNSAL TAN O., SABUNCUOĞLU S., Arafa R. K., BALKAN A.
DRUG DEVELOPMENT RESEARCH
, cilt.85, sa.8, 2024 (SCI-Expanded, Scopus)
2024
20243. Synthesis, Molecular Modeling and Biological Assessment of Aryloxymethyl 1,3,4-Thiadiazole and 1,2,4-Triazole-5-Thione Derivatives as Potential Cox Inhibitors
Shirzad M. M., ÖZADALI SARI K., ÜNSAL TAN O., HUSSEINI A. A., PALASKA E.
PHARMACEUTICAL CHEMISTRY JOURNAL
, cilt.58, sa.2, ss.209-215, 2024 (SCI-Expanded, Scopus)
2024
20244. Synthesis and Tyrosinase Inhibitory Activity of Novel Benzimidazole/Thiazolidin-4-one Hybrid Derivatives
Khraisat L. M. A. F., SABUNCUOĞLU S., GİRGİN G., ÜNSAL TAN O.
Chemistry and Biodiversity
, cilt.21, sa.2, 2024 (SCI-Expanded, Scopus)
2024
20245. Synthesis, antimycobacterial and antifungal evaluation of new 4-(furan-2-ylmethyl)-6-methylpyridazin-3(2H)-ones
Karayavuz B., Vagolu S. k., KART D., Tonjum T., ÜNSAL TAN O.
JOURNAL OF THE SERBIAN CHEMICAL SOCIETY
, cilt.89, sa.11, ss.1423-1431, 2024 (SCI-Expanded, Scopus)
2022
20226. Design, Synthesis and Evaluation of Novel 4-(4-Chlorobenzyl)-6-methylpyridazin-3(2H)-one Derivatives as Hepatitis B Virus Inhibitors
ÜNSAL TAN O., Moncol J., Durantel D.
CHEMISTRYSELECT
, cilt.7, sa.40, 2022 (SCI-Expanded, Scopus)
2022
20227. Design, Synthesis and Cytotoxic Evaluation of N-Acylhydrazone-Incorporated Isoxazolo[4,5-d]pyridazin-4(5H)-one Derivatives
ÖZADALI SARI K., Ceylan S., Yucel E. S., SABUNCUOĞLU S., ÜNSAL TAN O.
CHEMISTRY & BIODIVERSITY
, cilt.19, sa.9, 2022 (SCI-Expanded, Scopus)
2022
20228. Investigation of anti-cholinesterase and anti-amyloidogenic activities of beta-lactam antibiotics
Ozer E. O., Mirza H. C., ÜNSAL TAN O., Turkoglu S.
TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
, cilt.47, sa.3, ss.359-369, 2022 (SCI-Expanded, Scopus, TRDizin)
2022
20229. Design and synthesis of new 2-oxoquinoxalinyl-1,2,4-triazoles as antitumor VEGFR-2 inhibitors
ZENGİN M., ÜNSAL TAN O., Arafa R. K., BALKAN A.
Bioorganic Chemistry
, cilt.121, 2022 (SCI-Expanded, Scopus)
2022
202210. Insights into the chemistry and therapeutic potential of acrylonitrile derivatives
ÜNSAL TAN O., ZENGİN M.
ARCHIV DER PHARMAZIE
, cilt.355, sa.3, 2022 (SCI-Expanded, Scopus)
2021
202111. Azolo[d]pyridazinones in medicinal chemistry
ÜNSAL TAN O., ÖZADALI SARI K.
FUTURE MEDICINAL CHEMISTRY
, cilt.13, ss.287-311, 2021 (SCI-Expanded, Scopus)
2020
202012. The structural diversity of ginsenosides affects their cholinesterase inhibitory potential
Ozer E. O., ÜNSAL TAN O., Turkoglu S.
TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
, cilt.45, sa.2, 2020 (SCI-Expanded, Scopus, TRDizin)
2020
202013. Novel benzimidazole-acrylonitrile hybrids and their derivatives: Design, synthesis and antimycobacterial activity
Sirim M. M., Krishna V. S., Sriram D., Tan O.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
, cilt.188, 2020 (SCI-Expanded, Scopus)
2019
201914. Some New Hydrazone Derivatives Bearing the 1,2,4-Triazole Moiety as Potential Antimycobacterial Agents
ÖZADALI SARI K., ÜNSAL TAN O., Sriram D., BALKAN A.
TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES
, cilt.16, sa.4, ss.432-436, 2019 (ESCI, Scopus, TRDizin)
2019
201915. Design and Synthesis of 2-Substitutedphenyl Benzo[D]Thiazole Derivatives and Their β-Amyloid Aggregation and Cholinesterase Inhibitory Activities
ZENGİN M., Unsal-Tan O., Küçükkılınç T. T., AYAZGÖK B., BALKAN A.
Pharmaceutical Chemistry Journal
, cilt.53, sa.4, ss.322-328, 2019 (SCI-Expanded, Scopus)
2019
201916. Synthesis, molecular docking, and biological evaluation of novel 2-pyrazoline derivatives as multifunctional agents for the treatment of Alzheimer's disease
Unsal-Tan O., Kuecuekkilinc T. T., AYAZGÖK B., BALKAN A., Ozadali-Sari K.
MedChemComm
, cilt.10, sa.6, ss.1018-1026, 2019 (SCI-Expanded, Scopus)
2017
201717. Novel 2-Arylbenzimidazole derivatives as multi-targeting agents to treat Alzheimer’s disease
Unsal-Tan O., Ozadali-Sari K., AYAZGÖK B., Küçükkılınç T. T., BALKAN A.
Medicinal Chemistry Research
, cilt.26, sa.7, ss.1506-1515, 2017 (SCI-Expanded, Scopus)
2017
201718. Novel multi-targeted agents for Alzheimer's disease: Synthesis, biological evaluation, and molecular modeling of novel 2-[4-(4-substitutedpiperazin-1-yl)phenyl]benzimidazoles
Ozadali-Sari K., Tüylü Küçükkılınç T., AYAZGÖK B., BALKAN A., Unsal-Tan O.
Bioorganic Chemistry
, cilt.72, ss.208-214, 2017 (SCI-Expanded, Scopus)
2017
201719. A comparative study on monomer elution and cytotoxicity of different adhesive restoration materials
Toz T., KIREMITCI A., ÇAKMAK A. S., TAN O., PALASKA E., GUEMUESDERELIOGLU M., et al.
Journal of Adhesion Science and Technology
, cilt.31, sa.4, ss.414-429, 2017 (SCI-Expanded, Scopus)
2016
201620. Novel thiazolidinone-azole hybrids: Design, synthesis and antimycobacterial activity studies
EROGLU B., Ozadali-Sari K., Unsal-Tan O., Dharmarajan S., Yogeeswari P., BALKAN A.
Iranian Journal of Pharmaceutical Research
, cilt.15, sa.4, ss.783-790, 2016 (SCI-Expanded, Scopus)
2015
201521. Novel thiazolo[3,2-b]-1,2,4-triazoles derived from naproxen with analgesic/anti-inflammatory properties: Synthesis, biological evaluation and molecular modeling studies
SARIGOL D., UZGOREN-BARAN A., TEL B. C., Somuncuoglu E. İ., KAZKAYASI İ., OZADALI-SARI K., et al.
BIOORGANIC & MEDICINAL CHEMISTRY
, cilt.23, sa.10, ss.2518-2528, 2015 (SCI-Expanded, Scopus)
2015
201522. 1,2-Diaryl-2-hydroxyiminoethanones as Dual COX-1 and beta-Amyloid Aggregation Inhibitors: Biological Evaluation and In Silico Study
IRANNEJAD H., Tan O., Ozadali K., DADASHPOUR S., Kucukkilinc T. T., AHANGAR N., et al.
CHEMICAL BIOLOGY & DRUG DESIGN
, cilt.85, sa.4, ss.494-503, 2015 (SCI-Expanded, Scopus)
2015
201523. Design, Synthesis and In Vitro Study of 5,6-Diaryl-1,2,4-triazine-3-ylthioacetate Derivatives as COX-2 and beta-Amyloid Aggregation Inhibitors
DADASHPOUR S., Kucukkilinc T. T., Tan O., Ozadali K., IRANNEJAD H., EMAMI S.
ARCHIV DER PHARMAZIE
, cilt.348, sa.3, ss.179-187, 2015 (SCI-Expanded, Scopus)
2015
201524. Molecular docking studies and biological evaluation of chalcone based pyrazolines as tyrosinase inhibitors and potential anticancer agents
QIN H., SHANG Z., JANTAN I., Tan O. U., HUSSAIN M. A., SHER M., et al.
RSC ADVANCES
, cilt.5, sa.57, ss.46330-46338, 2015 (SCI-Expanded, Scopus)
2014
201425. Biological Activity and Molecular Docking Studies of Curcumin-Related alpha,beta-Unsaturated Carbonyl-Based Synthetic Compounds as Anticancer Agents and Mushroom Tyrosinase Inhibitors
Bukhari S. N. A., Jantan I., Tan O., Sher M., Naeem-ul-Hassan M., Qin H.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
, cilt.62, sa.24, ss.5538-5547, 2014 (SCI-Expanded, Scopus)
2014
201426. Synthesis and antimycobacterial activities of some new thiazolylhydrazone derivatives
Ozadali K., Tan O., Yogeeswari P., Dharmarajan S., BALKAN A.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
, cilt.24, sa.7, ss.1695-1697, 2014 (SCI-Expanded, Scopus)
2014
201427. 1-(4-Methoxyphenyl)-5-(3,4,5-trimethoxyphenyl)-1H-1,2,4-triazole-3-carboxamides: Synthesis, molecular modeling, evaluation of their anti-inflammatory activity and ulcerogenicity
Abdel-Aziz M., Beshr E. A., Abdel-Rahman I. M., Ozadali K., Tan O., Aly O. M.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
, cilt.77, ss.155-165, 2014 (SCI-Expanded, Scopus)
2013
201328. Synthesis, molecular modeling and evaluation of novel N '-2-(4-benzylpiperidin-/piperazin-1-yl)acylhydrazone derivatives as dual inhibitors for cholinesterases and A beta aggregation
Ozer E. O., TAN O., Ozadali K., KUCUKKILINC T., BALKAN A., UÇAR G.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
, cilt.23, sa.2, ss.440-443, 2013 (SCI-Expanded, Scopus)
2012
201229. Molecular modeling, synthesis and screening of some new 4-thiazolidinone derivatives with promising selective COX-2 inhibitory activity
UNSAL-TAN O., OZADALI K., Piskin K., BALKAN A.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
, cilt.57, ss.59-64, 2012 (SCI-Expanded, Scopus)
2012
201230. Synthesis and Evaluation of Human Monoamine Oxidase Inhibitory Activities of Some 3,5-Diaryl-N-substituted-4,5-dihydro-1H-pyrazole-1-carbothioamide Derivatives
Senturk K., Tan O., Ciftci S. Y., UÇAR G., PALASKA E.
ARCHIV DER PHARMAZIE
, cilt.345, sa.9, ss.695-702, 2012 (SCI-Expanded, Scopus)
2012
201231. Synthesis and antimycobacterial activities of some new N-acylhydrazone and thiosemicarbazide derivatives of 6-methyl-4,5-dihydropyridazin-3(2H)-one
Tan O., Ozadali K., Yogeeswari P., Sriram D., BALKAN A.
MEDICINAL CHEMISTRY RESEARCH
, cilt.21, sa.9, ss.2388-2394, 2012 (SCI-Expanded, Scopus)
2011
201132. Synthesis and evaluation of the analgesic activity of some new isoxazolo[4,5-d]pyridazin-4(5H)-one derivatives
Tan O. U., Ozadali K., Yesilyurt O., Kayir H., Uzbay T., BALKAN A.
TURKISH JOURNAL OF CHEMISTRY
, cilt.35, sa.1, ss.121-130, 2011 (SCI-Expanded, Scopus, TRDizin)
2010
201033. Synthesis and cyclooxygenase inhibitory activities of some N-acylhydrazone derivatives of isoxazolo[4,5-d]pyridazin-4(5H)-ones
UENSAL-TAN O., Oezden K., Rauk A., BALKAN A.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
, cilt.45, sa.6, ss.2345-2352, 2010 (SCI-Expanded, Scopus)
2006
200634. The in vivo metabolism of 3-oxo-5-benzylidene-6-methyl-(4H)-2-(benzoylmethyl)pyridazine in rats
Oruc E., Unsal O., Balkan A., Ozkanli F., Goren M., TERZİOĞLU BEBİTOĞLU B., et al.
EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS
, cilt.31, sa.1, ss.21-25, 2006 (SCI-Expanded, Scopus)
Hakemli Bilimsel Toplantılarda Yayımlanmış Bildiriler
2018
20181. Studies on Some Benzothiazole Derivatives
ZENGİN M., BALKAN A., ÜNSAL TAN O., TÜYLÜ KÜÇÜKKILINÇ Z. T., AYAZGÖK B.
12. International Symposium on Pharmaceutical Sciences, ISOPS, Ankara, Türkiye, 26 - 29 Haziran 2018, (Tam Metin Bildiri)
2018
20182. Synthesis and Evaluation of Benzimidazole and 2-pyrazoline Derivatives as Multi-Target-Directed Ligands against Alzheimer’s Disease
ÜNSAL TAN O., ÖZADALI SARI K., AYAZGÖK B., TÜYLÜ KÜÇÜKKILINÇ Z. T., BALKAN A.
12. International Symposium on Pharmaceutical Sciences, ISOPS, Ankara, Türkiye, 26 - 29 Haziran 2018, (Tam Metin Bildiri)
2017
20173. N-ACETYL DERIVATIVES OF 2-PYRAZOLINES AS POTENT MULTI-TARGETING AGENTS FOR ALZHEIMER’S DISEASE
ÖZADALI SARI K., TÜYLÜ KÜÇÜKKILINÇ Z. T., AYAZGÖK B., BALKAN A., ÜNSAL TAN O.
2nd International Gazi Pharma Symposium Series, 11 - 13 Ekim 2017, (Özet Bildiri)
2017
20174. 4,5-dihydro-1h-pyrazoles as cholinesterase and AB aggregation inhibitors for Alzheimer’xxs disease
TÜYLÜ KÜÇÜKKILINÇ Z. T., AYAZGÖK B., ÖZADALI SARI K., BALKAN A., ÜNSAL TAN O.
Uluslararası Biyokimya Kongresi 2017- 28. Ulusal Biyokimya kongresi, 19 - 23 Eylül 2017, (Özet Bildiri)
2017
20175. 4,5-dihydro-1h-pyrazoles as cholinesterase and Aβ aggregation inhibitors for Alzheimer’s disease
TÜYLÜ KÜÇÜKKILINÇ Z. T., AYAZGÖK B., ÖZADALI SARI K., BALKAN A., ÜNSAL TAN O.
28. Ulusal biyokimya Kongresi, Erzurum, Türkiye, 19 - 23 Eylül 2017, (Özet Bildiri)
2016
20166. Novel benzimidazole derivatives with multi functions on cholinesterase enzymes and neuroprotection
Ayazgök B., Tüylü Küçükkılınç Z. T., Özadalı Sarı K., Ünsal Tan O., Balkan A.
: 15th International Symposium on Cholinergic Mechanisms (ISCM), Marseille, Fransa, 16 - 20 Ekim 2016, cilt.142, ss.188, (Özet Bildiri)
Desteklenen Projeler
2022 - 2024
2022 - 2024VEGFR2 İnhibitörü Olarak Etki Göstermesi Beklenen Yeni İndol-2-on Türevleri Üzerinde Çalışmalar
Yükseköğretim Kurumları Destekli Proje , BAP Diğer
ÜNSAL TAN O. (Yürütücü), ZENGİN M.
2019 - 2020
2019 - 2020AKRİLONİTRİL YAPISI TAŞIYAN BENZİMİDAZOL TÜREVLERİNİN SENTEZİ VE ANTİMİKOBAKTERİYEL AKTİVİTELERİNİN İNCELENMESİ
Yükseköğretim Kurumları Destekli Proje , BAP Diğer
ÜNSAL TAN O. (Yürütücü), SIRIM M. M.
2018 - 2019
2018 - 20192-Fenilbenzotiyazol Türevleri Üzerinde Çalışmalar
Yükseköğretim Kurumları Destekli Proje , BAP Diğer
BALKAN A. (Yürütücü), TÜYLÜ KÜÇÜKKILINÇ Z. T., ÜNSAL TAN O., ZENGİN M., AYAZGÖK B.
2015 - 2016
2015 - 2016
TS EN ISO/IEC 17025 Standardı kapsamında Hacettepe Üniversitesi Eczacılık Fakültesi İlaç ve Kozmetik Ar-Ge ve Kalite Kontrol Laboratuvarının (HÜNİKAL) Akreditasyonu Projesi
Yükseköğretim Kurumları Destekli Proje , BAP Alt Yapı
GÜRSOY R. N. (Yürütücü), GÜMÜŞEL B., TÜYLÜ KÜÇÜKKILINÇ Z. T., SABUNCUOĞLU S., ŞÖHRETOĞLU D., KILIÇ E., et al.