Investigation of anti-cholinesterase and anti-amyloidogenic activities of beta-lactam antibiotics
TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, vol.47, no.3, pp.359-369, 2022 (SCI-Expanded, Scopus, TRDizin)
- Publication Type: Article / Article
- Volume: 47 Issue: 3
- Publication Date: 2022
- Doi Number: 10.1515/tjb-2021-0277
- Journal Name: TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, EMBASE, Food Science & Technology Abstracts, TR DİZİN (ULAKBİM)
- Page Numbers: pp.359-369
- Keywords: beta-lactam antibiotics, acetylcholinesterase, amyloid beta peptides, butyrylcholinesterase, molecular docking, BUTYRYLCHOLINESTERASE, ACETYLCHOLINESTERASE
- Open Archive Collection: AVESIS Open Access Collection
- Hacettepe University Affiliated: Yes
Abstract
Objectives: Neuroinflammation is an important factor in the pathogenesis of neurodegenerative disesases. The following study aimed to clarify the effects of beta-lactam antibiotics to the cholinergic system, on acetylcholinesterase (AChE), butyrylcholinesterase (BuChE) activities, considering the structural differences of antibiotics, to evaluate the underlying mechanism of effects provided by protein-antibiotic interactions, and to clarify possible effects of the antibiotics on the aggregation of A beta-peptides.