Investigation of anti-cholinesterase and anti-amyloidogenic activities of beta-lactam antibiotics

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Ozer E. O., Mirza H. C., ÜNSAL TAN O., Turkoglu S.

TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, vol.47, no.3, pp.359-369, 2022 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 47 Issue: 3
  • Publication Date: 2022
  • Doi Number: 10.1515/tjb-2021-0277
  • Journal Name: TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, EMBASE, Food Science & Technology Abstracts, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.359-369
  • Keywords: beta-lactam antibiotics, acetylcholinesterase, amyloid beta peptides, butyrylcholinesterase, molecular docking, BUTYRYLCHOLINESTERASE, ACETYLCHOLINESTERASE
  • Hacettepe University Affiliated: Yes

Abstract

Objectives: Neuroinflammation is an important factor in the pathogenesis of neurodegenerative disesases. The following study aimed to clarify the effects of beta-lactam antibiotics to the cholinergic system, on acetylcholinesterase (AChE), butyrylcholinesterase (BuChE) activities, considering the structural differences of antibiotics, to evaluate the underlying mechanism of effects provided by protein-antibiotic interactions, and to clarify possible effects of the antibiotics on the aggregation of A beta-peptides.