Synthesis, antimycobacterial and antifungal evaluation of new 4-(furan-2-ylmethyl)-6-methylpyridazin-3(<i>2H</i>)-ones

Karayavuz B., Vagolu S. k., KART D., Tonjum T., ÜNSAL TAN O.

JOURNAL OF THE SERBIAN CHEMICAL SOCIETY, sa.11, ss.1423-1431, 2024 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Basım Tarihi: 2024
  • Doi Numarası: 10.2298/jsc230424040k
  • Dergi Adı: JOURNAL OF THE SERBIAN CHEMICAL SOCIETY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aerospace Database, Aquatic Science & Fisheries Abstracts (ASFA), CAB Abstracts, Central & Eastern European Academic Source (CEEAS), Chemical Abstracts Core, Communication Abstracts, Food Science & Technology Abstracts, Metadex, Directory of Open Access Journals, Civil Engineering Abstracts
  • Sayfa Sayıları: ss.1423-1431
  • Hacettepe Üniversitesi Adresli: Evet

Özet

This study reports the synthesis and evaluation of a series of new pyridazin-3-ones with furan moieties 5a-j and 6a - f , to test for their antimycobacterial and antifungal activities. The structures of the target compounds were confirmed by elemental analysis and spectroscopic techniques (IR, mass, H-1- and C-13-NMR). Amongst the compounds tested, 5e , 5g , 5i and 6e exhibited highest activity against Mycobacterium tuberculosis, while 5h , 6d and 6f showed moderate in vitro antifungal activities against Candida albicans and Candida parapsilosis.