ARCHIV DER PHARMAZIE, vol.355, no.3, 2022 (SCI-Expanded)
Article / Review
ARCHIV DER PHARMAZIE
Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, CAB Abstracts, Chemical Abstracts Core, Chimica, EMBASE, International Pharmaceutical Abstracts, MEDLINE, Veterinary Science Database
acrylonitrile, biological activities, structure-activity relationship, synthesis, alpha,beta-unsaturated nitrile, IN-VITRO, ALPHA,BETA-UNSATURATED NITRILES, ANTICANCER AGENTS, UNSATURATED NITRILES, MYCOBACTERIUM-TUBERCULOSIS, ANTIPROLIFERATIVE ACTIVITY, BENZIMIDAZOLE DERIVATIVES, HETEROARYL-ACRYLONITRILES, STEREOSELECTIVE-SYNTHESIS, TUBULIN POLYMERIZATION
Hacettepe University Affiliated:
Acrylonitrile is a fascinating scaffold widely found in many natural products, drugs, and drug candidates with various biological activities. Several drug molecules such as entacapone, rilpivirine, teriflunomide, and so forth, bearing an acrylonitrile moiety have been marketed. In this review, diverse synthetic strategies for constructing desired acrylonitriles are discussed, and the different biological activities and medicinal significance of various acrylonitrile derivatives are critically evaluated. The information gathered is expected to provide rational guidance for the development of clinically useful agents from acrylonitriles.