Insights into the chemistry and therapeutic potential of acrylonitrile derivatives

ÜNSAL TAN O., ZENGİN M.

ARCHIV DER PHARMAZIE, vol.355, no.3, 2022 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 355 Issue: 3
  • Publication Date: 2022
  • Doi Number: 10.1002/ardp.202100383
  • Journal Name: ARCHIV DER PHARMAZIE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, CAB Abstracts, Chemical Abstracts Core, Chimica, EMBASE, International Pharmaceutical Abstracts, MEDLINE, Veterinary Science Database
  • Keywords: acrylonitrile, biological activities, structure-activity relationship, synthesis, alpha,beta-unsaturated nitrile, IN-VITRO, ALPHA,BETA-UNSATURATED NITRILES, ANTICANCER AGENTS, UNSATURATED NITRILES, MYCOBACTERIUM-TUBERCULOSIS, ANTIPROLIFERATIVE ACTIVITY, BENZIMIDAZOLE DERIVATIVES, HETEROARYL-ACRYLONITRILES, STEREOSELECTIVE-SYNTHESIS, TUBULIN POLYMERIZATION
  • Hacettepe University Affiliated: Yes

Abstract

Acrylonitrile is a fascinating scaffold widely found in many natural products, drugs, and drug candidates with various biological activities. Several drug molecules such as entacapone, rilpivirine, teriflunomide, and so forth, bearing an acrylonitrile moiety have been marketed. In this review, diverse synthetic strategies for constructing desired acrylonitriles are discussed, and the different biological activities and medicinal significance of various acrylonitrile derivatives are critically evaluated. The information gathered is expected to provide rational guidance for the development of clinically useful agents from acrylonitriles.