Synthesis and evaluation of the analgesic activity of some new isoxazolo[4,5-d]pyridazin-4(5H)-one derivatives

Tan, Oya; Ozadali, KERİMAN; Yesilyurt, Ozgur; Kayir, Hakan; Uzbay, OYA; BALKAN, AYLA

doi:10.3906/kim-1004-584

Synthesis and evaluation of the analgesic activity of some new isoxazolo[4,5-d]pyridazin-4(5H)-one derivatives

Tan O. U., Ozadali K., Yesilyurt O., Kayir H., Uzbay T., BALKAN A.

TURKISH JOURNAL OF CHEMISTRY, cilt.35, sa.1, ss.121-130, 2011 (SCI-Expanded, Scopus, TRDizin)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 35 Sayı: 1
Basım Tarihi: 2011
Doi Numarası: 10.3906/kim-1004-584
Dergi Adı: TURKISH JOURNAL OF CHEMISTRY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
Sayfa Sayıları: ss.121-130
Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
Hacettepe Üniversitesi Adresli: Evet

Some isoxazolo[4,5-d] pyridazin4(5H)-one derivatives were synthesized and tested for their analgesic activity. The analgesic activities of the compounds were determined by hot-plate and acetic acid writhing tests using morphine and diclofenac as references. Compounds 4a, 4f, 4g, and 4i (25 mg/kg) showed analgesic profiles similar to that of morphine (5 mg/kg).

Some isoxazolo[4,5-d]pyridazin4(5H) -one derivatives were synthesized and tested for their analgesic activity. The analgesic activities of the compounds were determined by hot-plate and acetic acid writhing tests using morphine and diclofenac as references. Compounds 4a, 4f, 4g, and 4i (25 mg/kg) showed analgesic profiles similar to that of morphine (5 mg/kg).