Education Information
1994 - 1997
1994 - 1997Doctorate
Imperial College of Science, Technology and Medicine, Biyokimya, Moleküler Biyoloji Ve Genetik, United Kingdom
1983 - 1989
1983 - 1989Undergraduate
Istanbul University, Istanbul Medical Faculty, Turkey
Dissertations
1997
1997Doctorate
Cloning and characterization of the Salmonella typhimurium dehydroquinate synthase
Imperial College of Science, Technology and Medicine, Life Sciences, Biochemistry
Foreign Languages
C1 Advanced
C1 AdvancedEnglish
A2 Elementary
A2 ElementaryGerman
Research Areas
Medicine
Medical Biology
Pharmaceutical Biotechnology
Life Sciences
Molecular Biophysics
Molecular Biochemistry
Molecular Biology and Genetics
Genetic Disorders
Genetic Engineering
Moleculer Biology of Cancer
Health Sciences
Fundamental Medical Sciences
Academic Titles / Tasks
2019 - Continues
2019 - ContinuesProfessor
Hacettepe University, Sağlık Bilimleri Enstitüsü, Kök Hücre Bilimleri A.B.D.
2012 - 2019
2012 - 2019Associate Professor
Hacettepe University, Sağlık Bilimleri Enstitüsü, Kök Hücre Bilimleri A.B.D.
2010 - 2012
2010 - 2012Associate Professor
Hacettepe University, Çocuk Sağlığı Enstitüsü
2008 - 2010
2008 - 2010Lecturer PhD
Hacettepe University, Tıp Fakültesi (İngilizce), Dahili Tıp Bilimleri Bölümü
2008 - 2010
2008 - 2010Lecturer PhD
Hacettepe University, Çocuk Sağlığı Enstitüsü
2001 - 2008
2001 - 2008Assistant Professor
Kirikkale University, Faculty of Medicine, Medical Biology and Genetics
1999 - 2000
1999 - 2000Expert PhD
Manisa Celal Bayar University, Faculty of Medicine, Tıbbi Biyoloji ve Genetik
1994 - 1999
1994 - 1999Research Assistant PhD
Manisa Celal Bayar University, Faculty of Medicine, Department of Biophysics
Managerial Experience
2017 - Continues
2017 - ContinuesAcademic Performance D. Board Member
Hacettepe University, Sağlık Bilimleri Enstitüsü, Kök Hücre Bilimleri A.B.D.
2015 - Continues
2015 - ContinuesDeputy Director of the Center
Hacettepe University, --------------------------------, Transgenik Hayvan Teknolojileri
2011 - Continues
2011 - ContinuesAcademic Board Member
Hacettepe Üniversitesi, Kök Hücre Bilimleri Anabilim Dalı
2018 - 2024
2018 - 2024Head of Department
Hacettepe University, Sağlık Bilimleri Enstitüsü, Kök Hücre Bilimleri A.B.D.
2021 - 2022
2021 - 2022Academic Council Member of Department
Hacettepe University, Eczacılık Fakültesi, Eczacılık Teknolojisi Bölümü
2008 - 2010
2008 - 2010Academic Council Member of Department
Hacettepe University, Tıp Fakültesi (İngilizce), Dahili Tıp Bilimleri Bölümü
2001 - 2008
2001 - 2008Head of Department
Kirikkale University, Faculty Of Medıcıne, Department Of Medical Biology and Genetics
2001 - 2008
2001 - 2008Fakülte Akademik Kurul Üyesi
Kirikkale University, Faculty Of Medıcıne, Department Of Basıc Medıcal Scıences
Non Academic Experience
2024 - Continues
2024 - Continues'Delivery strategies' Çalışma Grubu üyesi (WG3)
European Union, European Cooperation in Science & Technology, Gene Therapy for the treatment of human Disease Network (GeneHumdi | COST action CA21113)
2024 - Continues
2024 - ContinuesWorking group member
European Union, European Cooperation in Science & Technology, CA21154 - Translational control in Cancer European Network (TRANSLACORE)
2022 - Continues
2022 - ContinuesCommission Member
Professional Association, Tıbbi Genetik Derneği, İleri Tedaviler Komisyonu
2009 - 2013
2009 - 2013COST Action BM0805 Management Committee Member
European Union, European Cooperation in Science & Technology , Cost Action BM0805 HOX and TALE transcription factors in Development and Disease
1994 - 1997
1994 - 1997PhD candidate
University, University of London, Imperial College Science Technology & Medicine, Biochemistry
1989 - 1993
1989 - 1993Medical Doctor, General Practioner
Ministry, Sağlık Bakanlığı , Sağlık Ocağı
Courses
Advising Theses
2024
2024Postgraduate
Hepatosit büyüme faktörü (HGF) ile lisanslanmış mezenkimal kök hücrelerde anti-fibrotik mirna ifade düzeyleri
Özcan A. (Advisor)
A.BERK(Student)
2023
2023Postgraduate
Kemik İliği Mezenkimal Kök Hücrelerinde p53 Yolağı Regülasyonunda PKNOX2 ve Etkileşimlerinin Araştırılması
Özcan A. (Advisor)
M.KELEŞ(Student)
2023
2023Doctorate
Podosit Hasar Modelinde İndüklenmiş Mezenkimal Kök Hücrelerinin Etkisi
Özcan A. (Advisor)
Ö.Burcu(Student)
2022
2022Postgraduate
Gene Expression Omnibus (GEO) Veribankası kaynakları kullanılarak nöral krest kaynaklı dental kök hücrelerinin, nörojenik rejenerasyon ile ilişkili gen ifade profillerinin karşılaştırılmalı olarak incelenmesi
Özcan A. (Advisor)
A.CEVDET(Student)
2021
2021Postgraduate
Mezenkimal Kök Hücre Yaşlanmasında NF-κB/p65 ve PKNOX2 Protein-protein Etkileşimlerinin İncelenmesi
Özcan A. (Advisor)
E.KOÇAK(Student)
2019
2019Postgraduate
Kemik İliği Mezenkimal Kök Hücrelerinde PKNOX2 Proteinin ATM ve RNF8 ile Etkileşimlerinin İncelenmesi
Özcan A. (Advisor)
N.DÖNMEZ(Student)
2018
2018Doctorate
Hox and tale transcription factors in fanconi anemia bone-marrow mesenchymal stem cells: Gene expression and protein interactions
Özcan A. (Advisor)
I.ÇAĞNAN(Student)
2015
2015Doctorate
pGITRL aktarılan mezenkimal kök hücrelerin küçük hücreli akciğer kanserine in vitro etkisi ve altın nanopartiküllerle işaretlenmesi
Özcan A. (Co-Advisor), Korkusuz P.
Ç.ZÜBEYDE(Student)
2006
2006Doctorate
Fare IL-18 veya CD40L genlerini taşıyan rekombinant Salmonella typhimurium aroB suşlarının oluşturulması ve gen tedavisi vektörü olarak değerlendirilmesi
Özcan A. (Co-Advisor), Güç D.
D.AYDIN(Student)
2003
2003Postgraduate
CD40 ligand (CD154) genin ökaryotik ekspresyon vektörüne klonlanması
ÖZCAN A. (Co-Advisor)
G.ESENDAĞLI(Student)
Published journal articles indexed by SCI, SSCI, and AHCI
2024
2024Hypoxia and Hypoxia Mimetic Agents As Potential Priming Approaches to Empower Mesenchymal Stem Cells.
Yasan G. T., Gunel-Ozcan A.
Current stem cell research & therapy
, vol.19, no.1, pp.33-54, 2024 (SCI-Expanded)
2022
2022Global miRNA expression of bone marrow mesenchymal stem/stromal cells derived from Fanconi anemia patients
Cagnan I., Keles M., Keskus A. G., Tombaz M., ŞAHAN Ö. B., AERTS KAYA F. S. F., et al.
HUMAN CELL
, vol.35, no.1, pp.111-124, 2022 (SCI-Expanded)
2021
2021Single dose application IGF-1 and HGF induced bone marrow mesenchymal stem cells reduced proteinuria in focal segmental gomerulosclerosis model
Şahan Ö. B., Onbaşılar İ., Güçer K. Ş., Kaymaz F. F., Atayar E., Özaltın F., et al.
FEBS OPEN BIO
, vol.11, pp.35, 2021 (SCI-Expanded)
2021
2021Development, characterization, and hematopoietic differentiation of Griscelli syndrome type 2 induced pluripotent stem cells.
Güney-Esken G., Erol Ö. D., Pervin B., Gürhan Sevinç G., Önder T., Bilgiç E., et al.
Stem cell research & therapy
, vol.12, no.1, pp.287, 2021 (SCI-Expanded)
2021
2021Hepatocyte Growth Factor and Insulin-like Growth Factor-1 Based Cellu-lar Therapies for Oxidative Stress Injury
Şahan Ö. B., Özcan A.
CURRENT STEM CELL RESEARCH & THERAPY
, vol.16, no.7, pp.771-791, 2021 (SCI-Expanded)
2021
2021Stem Cells under Stress
ÖZCAN A.
CURRENT STEM CELL RESEARCH & THERAPY
, vol.16, no.7, pp.753-754, 2021 (SCI-Expanded)
2020
2020IGF-1 and HGF Preconditioning of Bone Marrow Mesenchymal Stem Cells Reduced Proteinuria in Rat Focal Segmental Glomerulosclerosis Model
Sahan Ö. B., Onbaşılar İ., Güçer K. Ş., Kaymaz F. F., Atayar E., Özaltın F., et al.
CYTOTHERAPY
, vol.22, no.5, 2020 (SCI-Expanded)
2019
2019PKNOX2 expression and regulation in the bone marrow mesenchymal stem cells of Fanconi anemia patients and healthy donors.
Cagnan I., Cosgun E., Konu O., Uckan D., Gunel-Ozcan A.
Molecular biology reports
, vol.46, pp.669-678, 2019 (SCI-Expanded)
2018
2018Dual Effect of Glucocorticoid-Induced Tumor Necrosis Factor-Related Receptor Ligand Carrying Mesenchymal Stromal Cells on Small Cell Lung Cancer: A Preliminary in vitro Study
KÖPRÜ C. Z., Cagnan I., AKAR İ., ESENDAĞLI G., KORKUSUZ P., Gunel-Ozcan A.
CYTOTHERAPY
, vol.20, no.7, pp.930-940, 2018 (SCI-Expanded)
2018
2018Effect of IGF-1 and HGF induced bone marrow mesenchymal stem cells on focal segmental glomerulosclerosis in Sprague-Dawley rats: a pilot study
ŞAHAN Ö., KORKMAZ E., ONBAŞILAR İ., Gucer S., KAYMAZ F. F., ÖZALTIN F., et al.
FEBS OPEN BIO
, vol.8, pp.152, 2018 (SCI-Expanded)
2018
2018Effect of IGF1 and HGF Induced Bone Marrow Mesenchymal Stem Cells on Focal Segmental Glomerulosclerosis in SpragueDawley Rats: A pilot study
Şahan Ö. B., Korkmaz E., Onbaşılar İ., Güçer K. Ş., Kaymaz F. F., Özaltın F., et al.
FEBS OPEN BIO , vol.8, pp.152, 2018 (SCI-Expanded)
2018
2018Bone Marrow Mesenchymal Stem Cells Carrying FANCD2 Mutation Differ from the Other Fanconi Anemia Complementation Groups in Terms of TGF-beta 1 Production
CAGNAN I., GUNEL-OZCAN A., AERTS-KAYA F. S. F., Ameziane N., Kuskonmaz B., Dorsman J., et al.
STEM CELL REVIEWS AND REPORTS
, vol.14, no.3, pp.425-437, 2018 (SCI-Expanded)
2017
2017Stably expressed reference genes during differentiation of bone marrow-derived mesenchymal stromal cells
Cagnan I., Aerts Kaya F. S. F., Uckan D., Gunel Ozcan A.
TURKISH JOURNAL OF BIOLOGY
, vol.41, no.1, pp.88-97, 2017 (SCI-Expanded)
2017
2017From Stem Cell Biology to The Treatment of Lung Diseases
Esendagli D., Gunel-Ozcan A.
CURRENT STEM CELL RESEARCH & THERAPY
, vol.12, no.6, pp.493-505, 2017 (SCI-Expanded)
2016
2016Change in HOX gene expression by osteogenic differentiation capacity of human bone marrow derived mesenchymal stromal stem cells
Cagnan I., AERTS KAYA F., UCKAN D., ÖZCAN A. G.
Human Gene Therapy , vol.27, pp.69, 2016 (SCI-Expanded)
2016
2016Differentially expressed miRNAs in the G CSF primed donor mesenchymal stem cells
GÜNEL ÖZCAN A., SAHAN O. B., Cagnan I., ÇETİNKAYA F. D.
Febs Journal , vol.283, pp.95-96, 2016 (SCI-Expanded)
2015
2015Unmodified Mesenchymal Stem Cells do not support in vitro T and B Cell differentiation of Hematopoietic Stem Cells
PARİSA S., CEVHER İ., GÜNEL ÖZCAN A., ÇETİNKAYA F. D., AERTS KAYA F.
Human Gene Therapy
, vol.26, pp.90, 2015 (SCI-Expanded)
2015
2015Genome wide non coding RNA expression profile indicates upregulation of hsa miR 761 in the bone marrow mesenchymal stromal cells of Fanconi Anemia patients
Cagnan I., ÇETİNKAYA F. D., ÖZCAN A.
Human Gene Therapy , vol.26, pp.86-87, 2015 (SCI-Expanded)
2014
2014miRNA Expression Profiling in Mesenchymal Stromal Stem Cells Derived from G CSF Primed Bone Marrows
GÜNEL ÖZCAN A., Cagnan I., Kansu E., ÇETİNKAYA F. D.
Blood , vol.124, 2014 (SCI-Expanded)
2014
2014Gene expression of Notch receptors and ligands by plastic adherent and prospectively isolated MSCs
AYDIN G., AERTS KAYA F., Cagnan I., GUENEL OEZCAN A., ÇETİNKAYA F. D.
Human Gene Therapy , vol.25, pp.116, 2014 (SCI-Expanded)
2014
2014The frequency of Familial Mediterranean fever gene mutations and genotypes at Kirikkale and comparison with the mean of regional MEFV mutation frequency of Turkey
Kocakap D. B. S., Gunel-Ozcan A., Cabuk F., Ensari C.
MOLECULAR BIOLOGY REPORTS
, vol.41, no.3, pp.1419-1426, 2014 (SCI-Expanded)
2013
2013DIFFERENTIAL MIRNA EXPRESSION PROFILE OF BONE MARROW DERIVED MESENCHYMAL STEM CELLS IN FANCONI ANEMIA PATIENTS AND HEALTHY DONORS
GÜNEL ÖZCAN A., Cagnan I., KONU KARAKAYALI Ö., AERTS KAYA F., KUŞKONMAZ B. B., ÇETİNKAYA F. D.
Experimental Hematology , vol.41, pp.61, 2013 (SCI-Expanded)
2012
2012Tenascin-R: Role in the central nervous system
Anlar B., Gunel-Ozcan A.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
, vol.44, no.9, pp.1385-1389, 2012 (SCI-Expanded)
2009
2009Hereditary haemochromatosis gene (HFE) H63D mutation shows an association with abnormal sperm motility
Gunel-Ozcan A., Basar M. M., Kisa U., Ankarali H. C.
MOLECULAR BIOLOGY REPORTS
, vol.36, no.7, pp.1709-1714, 2009 (SCI-Expanded)
2009
2009The spectrum of FMF mutations and genotypes in the referrals to molecular genetic laboratory at KÄaut +/- rÄaut +/- kkale University in Turkey
Gunel-Ozcan A., Sayin D. B., Misirlioglu E. D., Guliter S., Yakaryilmaz F., Ensari C.
MOLECULAR BIOLOGY REPORTS
, vol.36, no.4, pp.757-760, 2009 (SCI-Expanded)
2009
2009Coexistence of different tissue tumourigenesis in an N-methyl-N-nitrosourea-induced mammary carcinoma model: a histopathological report in Sprague-Dawley rats
ESENDAĞLI G., Yilmaz G., CANPINAR H., Gunel-Ozcan A., Guc M. O., Guc D.
LABORATORY ANIMALS
, vol.43, no.1, pp.60-64, 2009 (SCI-Expanded)
2009
2009Primary tumor cells obtained from MNU-induced mammary carcinomas show immune heterogeneity which can be modulated by low-efficiency transfection of CD40L gene
ESENDAĞLI G., CANPINAR H., Yilmaz G., Gunel-Ozcan A., Guc M. O., Kansu E., et al.
CANCER BIOLOGY & THERAPY
, vol.8, no.2, pp.136-142, 2009 (SCI-Expanded)
2009
2009Molecular and functional analysis of a novel recombinant clone of rat (Rattus norvegicus) CD40 ligand (CD40L) gene
ESENDAĞLI G., Gunel-Ozcan A., CANPINAR H., Guc D.
MOLECULAR BIOLOGY REPORTS
, vol.36, no.1, pp.83-89, 2009 (SCI-Expanded)
2008
2008Adhesion of beta1 integrin to fibronectin regulates CAM-DR phenotype via p21(WAF1/cip1) in HL60 acute myeloid leukemia (AML) cells
CANPINAR H., ESENDAĞLI G., Kansu E., Ozcan A. G., Guc D.
TURKISH JOURNAL OF MEDICAL SCIENCES
, vol.38, no.2, pp.97-104, 2008 (SCI-Expanded)
2006
2006Salmonella typhimurium aroB encoding murine IL 18 or CD40L evaluation for gene therapy
AYDIN D., GÜNEL ÖZCAN A., MENAGER N., ESENDAĞLI G., GÜÇ M. O., HAYRAN K. M., et al.
Febs Journal
, vol.273, pp.49-50, 2006 (SCI-Expanded)
2006
2006HFE H63D mutation frequency shows an increase in Turkish women with breast cancer
Gunel-Ozcan A., ALYILMAZ-BEKMEZ S., GULER E., GUC D.
BMC CANCER
, vol.6, 2006 (SCI-Expanded)
2003
2003pTARGET vector carrying IL 18 or CD40L genes for attenuated Salmonella typhimurium mediated gene therapy
BEK D., ESENDAĞLI G., GÜNEL ÖZCAN A., GÜÇ D., GÜÇ M. O., Kansu E.
Blood , vol.102, pp.491, 2003 (SCI-Expanded)
1998
1998Expression of recombinant aroB-encoded dehydroquinate synthase from pathogenic microorganisms.
SKINNER M., Gunel-ozcan A., SHAFIQ M., Maskell D., Brown K.
BIOCHEMICAL SOCIETY TRANSACTIONS
, vol.26, no.3, 1998 (SCI-Expanded)
1997
1997Dehydroquinate synthase binds divalent and trivalent cations: Role of metal binding in catalysis.
SKINNER M., Gunel-Ozcan A., Moore J., Hawkins A., Brown K.
BIOCHEMICAL SOCIETY TRANSACTIONS
, vol.25, no.4, 1997 (SCI-Expanded)
1997
1997Salmonella typhimurium aroB mutants are attentuated in BALB/c mice
Gunel-Ozcan A., Brown K., Allen A., Maskell D.
MICROBIAL PATHOGENESIS
, vol.23, no.5, pp.311-316, 1997 (SCI-Expanded)
Articles Published in Other Journals
2016
20162015 Nobel Kimya Ödülü nün önemi DNA Onarımı ve Kanser
GÜNEL ÖZCAN A., Kansu E.
Herkese Bilim Teknoloji
, 2016 (Non Peer-Reviewed Journal)
2009
2009Kritik Hastada Moleküler Biyoloji ve Genetik
Özcan A.
KATKI Pediatri dergisi , vol.31, no.2-3, pp.355-371, 2009 (Non Peer-Reviewed Journal)
Refereed Congress / Symposium Publications in Proceedings
2024
2024P119 Differential Expression Profile of miRNAs Indicates that HGF Priming Ameliorates Fibrosis Related miRNAs in Bone Marrow-derived Mesenchymal Stem Cells
Alişan A. B., Şahan Ö. B., Günel-Özcan A.
9 th International Congress of the Molecular Biology Association of Turkey, İzmir, Turkey, 12 - 14 September 2024, pp.160
2024
2024Intranasal treatment with hydrogen sulfide releasing donors can prevent bleomycin-induced pulmonary fibrosis in mice
Karaman Y., Büber E., Kurtulan O., Abohalaka R., Şahan Ö. B., Önder S. Ç., et al.
The ERS Congress 2024 , Vienna, Austria, 7 - 11 September 2024, vol.64, no.352, pp.352
2024
2024PRIMING BONE MARROW MESENCHYMAL STEM CELLS WITH HEPATOCYTE GROWTH FACTOR (HGF-MSC) AMELIORATES BLEOMYCİN-INDUCED PULMONARY FIBROSIS IN MICE
Şahan Ö. B., Karaman Y., Büber E., Kurtulan O., Abohalaka R., Önder S. Ç., et al.
ISSCR 2024, Hamburg, Germany, 10 - 13 July 2024, pp.660
2024
2024A new CRISPR-mediated Apc Knockout Allele leads to Pyloric Gland Adenoma-like Gastric Polyps in the Mice with C57BL/6; FVB/N Mixed Background
Uzun S., Özcan Ö., Gök A., Işık A., Bakır S., Günel-Özcan A., et al.
The First CRISPR Medicine Conference, Copenhagen Denmark, April 23-25, 2024 (virtual event April 22), Kobenhavn, Denmark, 23 - 25 April 2024, pp.92
2021
2021PS-250“Kemik iliği mezenkimal kök hücre yaşlanmasında PKNOX2 transkripsiyon faktörü NF- κB/p65’e eşlik ediyor olabilir
Koçak E., Şahan Ö. B., Çetinkaya F. D., Günel-Özcan A.
17. Tıbbi Biyoloji ve Genetik Kongresi , İstanbul, Turkey, 28 - 31 October 2021, pp.250
2021
2021P371“PKNOX2 can be a new player in NF-κB/p65 signaling in bone marrow mesenchymal stem cell senescence
Koçak E., Şahan Ö. B., Çetinkaya F. D., Günel-Özcan A.
European Society of Gene and Cell Therapy (ESGCT) Collaborative Virtual Congress, Brussels, Belgium, 19 - 22 October 2021, pp.371
2021
2021Repair of Griscelli Type 2 mesenchymal stem cells with a lentiviral vector carrying RAB27Aco
Erol Ö. D., Şeker M. E., Pervin B., Van Til N. P., Günel_Özcan A., Kocaefe Y. Ç., et al.
İstiniye Üniversitesi Kök Hücre ve Doku Mühendisliği Sempozyumu, İstanbul, Turkey, 27 - 28 February 2021
2019
2019OVCAR-3 adenokarsinoma over kanseri hücre hattında BMP-7 susturulması sonrası BMP-2, ZEB2 ve integrin α5-β1 ifadelerinin değerlendirilmesi
Bahador Zırh E., Şahan Ö. B., Zeybek N. D., Özcan A.
24. ULUSAL ELEKTRON MİKROSKOPİ KONGRESİ, Edirne, Turkey, 24 - 26 April 2019, pp.179
2018
2018PKNOX2 proteomics reveals novel interactions with ATM and RPS3A in bone marrow-derived mesenchymal stem cells
Günel-Özcan A., Ayhan N., Şahan Ö. B., Çağnan I., Warasnhe K., Çetinkaya F. D.
EMBO Workshop- RNA and genome maintenance Cooperation and conflict management, Mainz, Germany, 10 - 13 October 2018, pp.89
2018
2018Effect of IGF¬1 and HGF Induced Bone Marrow Mesenchymal Stem Cells on Focal Segmental Glomerulosclerosis in Sprague¬Dawley Rats: A pilot study
Sahan Ö. B., Korkmaz E., Onbaşılar İ., Güçer K. Ş., Kaymaz F. F., Özaltın F., et al.
43rd Febs Congress, Praha, Czech Republic, 7 - 12 July 2018
2018
2018Naif ve İndüklenmiş Mezenkimal Kök Hücrelerin Fokal Segmental Glomeruloskleroz Üzerine Etkisinin Sprague-Dawley Modeli Üzerinde İncelenmesi
Şahan Ö. B., Korkmaz E., Onbaşılar İ., Güçer K. Ş., Kaymaz F. F., Özaltın F., et al.
4. Klinik İmmunoloji Kongresi, Antalya, Turkey, 11 - 14 April 2018, pp.65
2016
2016High PKNOX2 level of mesenchymal stem cells prompts hematopoetic stem cell differentiation towards myeloid lineages in co-culture experiments
Cagnan I., Aertskaya F., Uckan D., Günel-Özcan A.
2nd International Conference on Stem Cells and Cancer, Antalya, Turkey, 15 November 2016 - 16 January 2018
2017
2017TGF-b1 production by bone marrow mesenchymal stem cells of FANCD2 differs from other Fanconi Anemia Complemetation Groups
Cagnan I., Günel-Özcan A., Aertskaya F., Ameziane N., Kuskonmaz B., Dorsman J., et al.
59th ASH Annual Meeting and Exposition (December 9-12), Georgia, United States Of America, 9 - 12 December 2017, vol.130
2017
2017Development and characterization of iPS cell lines from a patient with Griscelli type 2 disease
GUNEY G., PERVİN B., SAHAN Ö. B., ÇETİNKAYA F. D., ÖZCAN A., SCHAMBACH A., et al.
46th ISEH annual scientific meetings 2017 (24-28 Ağustos)Frankfurt, Almanya, Frankfurt, Germany, 24 - 27 August 2017
2017
2017PKNOX2 regulated by TGFbeta is a new candidate to explain bone marrow failure in Fanconi anemis
Cagnan I., AERTSKAYA F., COSGUN E., KONU KARAKAYALI Ö., ÇETİNKAYA F. D., ÖZCAN A.
46th ISEH Annual Scientific Meeting 2017 (24-27 Ağustos) Frankfurt, Almanya, Frankfurt, Germany, 24 - 27 August 2017, vol.53, pp.136
2017
2017Development and characterization of iPS cell lines from a patient with Griscelli type 2 disease.
Güney E. G., Pervin b., ŞAHAN Ö. B., ÇETİNKAYA F. D., ÖZCAN A., Schambach A., et al.
ISEH annual meeting 2017, Frankfurt, Germany, 24 - 27 August 2017, vol.53, pp.135
2017
2017PKNOX2 regulated by TGFbeta is a new candidate to explain bone marrow failure in Fanconi Anemia.
Cagnan I., Aerts Kaya F. S. F., Coşgun E., Konu Karakayalı Ö., Kuşkonmaz B. B., Çetinkaya F. D., et al.
ISEH annual meeting 2017, Frankfurt, Germany, 24 - 27 August 2017, vol.53, pp.136
2016
2016Change in HOX gene expression by osteogenic differentiation capacity of human bone marrow derived mesenchymal stromal/stem cells
Cagnan I., Aerts-Kaya F. S. F., Uckan D., ÖZCAN A.
Conference on Changing the Face of Modern Medicine - Stem Cells and Gene Therapy, Florence, Italy, 18 - 21 October 2016, vol.27
2016
2016PBX/Knotted 1 Homeobox 2 is an activator and a downstream target of transforming growth factor beta-1
Cagnan I., Cetinkaya D. U., ÖZCAN A.
41st FEBS Congress on Molecular and Systems Biology for a Better Life, Kusadasi, Turkey, 3 - 08 September 2016, vol.283, pp.59-60
2015
2015pCR3::GITRL transfected MSCs induce apoptotic cell death and SIVA1 expression in SCLC-21H lung cancer cell line
KOPRU C. Z., KORKUSUZ P., CAGNAN I., Akar-Soycan I., ESENDAĞLI G., ÖZCAN A.
Collaborative Congress of the European-Society-of-Gene-and-Cell-Therapy (ESGCT) and Finnish-Society-of-Gene-Therapy (FSGT), Helsinki, Finland, 17 - 20 September 2015, vol.26
2015
2015Genome-wide non-coding RNA expression profile indicates upregulation of hsa-miR-761 in the bone marrow mesenchymal stromal cells of Fanconi Anemia patients
Cagnan I., Uckan D., ÖZCAN A.
Collaborative Congress of the European-Society-of-Gene-and-Cell-Therapy (ESGCT) and Finnish-Society-of-Gene-Therapy (FSGT), Helsinki, Finland, 17 - 20 September 2015, vol.26
2015
2015Mesenchymal stem cells induce proliferation of NCI-H82 small cell lung cancer
KOPRU C. Z., CAGNAN I., Akar-Soycan I., ESENDAĞLI G., KORKUSUZ P., ÖZCAN A.
Collaborative Congress of the European-Society-of-Gene-and-Cell-Therapy (ESGCT) and Finnish-Society-of-Gene-Therapy (FSGT), Helsinki, Finland, 17 - 20 September 2015, vol.26
2015
2015Nanopartiküller ile işaretli pGITRL aktarılmış mezenkimal kök hücrelerin küçük hücreli akciğer kanseri hücreleriyle görüntülenmesi
KÖPRÜ C. Z., GÜNEL ÖZCAN A., Cagnan I., AKAR SOYCAN İ., ESENDAĞLI G., KORKUSUZ P.
22.nci Elektron Mikroskopi Kongresi (EMK 2015), İstanbul, Turkey, 2 - 04 September 2015
2015
2015Use of Mesenchymal Stem Cells as Feeder Cells to Support In Vitro T- and B-Cell Differentiation of Hematopoietic Stem Cells
Cevher İ., Sharafi P., Aydın G., ÖZCAN A., ÇETİNKAYA F. D., AERTS KAYA F. S. F.
V. Int congress of Mol Med 2015, İzmir, Turkey, 20 - 22 May 2015, pp.182
2015
2015KOAH da Kök Hücre Tedavisi
GÜNEL ÖZCAN A.
Türk Toraks Derneği 18. Yıllık Kongresi, Turkey, 1 - 05 April 2015
2015
2015Gene expression of Notch receptors and ligands by human Mesenchymal Stem Cells from different tissues
Aydin G., Aerts-Kaydz F., ÖZCAN A., Uckan-Cetinkaya D.
41st Annual Meeting of the European-Society-for-Blood-and-Marrow-Transplantation, İstanbul, Turkey, 22 - 25 March 2015, vol.50
2014
2014miRNA Expression Profiling in Mesenchymal Stromal/Stem Cells Derived from G-CSF Primed Bone Marrows
ÖZCAN A., Cagnan I., KANSU E., Uckan D.
56th Annual Meeting of the American-Society-of-Hematology, San-Francisco, Costa Rica, 6 - 09 December 2014, vol.124
2014
2014Fankoni Anemili Hastaların Kemik İliği Mezenkimal Kök Hücrelerinde PREP2 Gen İfadesi Donörlere Oranla Düşüş Göstermektedir.
ÇAĞNAN I., Coşgun E., KONU KARAKAYALI Ö., AERTS KAYA F. S. F., KUŞKONMAZ B. B., ÖZCAN A.
1. Kök Hücre ve Hücresel Tedaviler Kongresi 2014, Kocaeli, Turkey, 20 - 23 March 2014
2013
2013Expression of HAS-MIR-3065-3P was significantly downregulated in fanconi anemia patient bone marrow derived mesenchymal stem cells following bone marrow transplantation.
Cagnan I., KONU KARAKAYALI Ö., AERTS KAYA F. S. F., Kuskonmaz B., ÇETİNKAYA F. D., ÖZCAN A.
ISSCR 2013, 15 - 18 September 2013, pp.37-38
2013
2013DIFFERENTIAL MIRNA EXPRESSION PROFILE OF BONE MARROW DERIVED MESENCHYMAL STEM CELLS IN FANCONI ANEMIA PATIENTS AND HEALTHY DONORS
Özcan A., Cagnan I., Konu O., Kaya F. A., Kuşkonmaz B. B., Uckan D.
42nd Annual Scientific Meeting of the International-Society-for-Experimental-Hematology-and-Stem-Cells (ISEH), Vienna, Austria, 22 - 25 August 2013, vol.41
2013
2013Interaction of mesenchymal stem and HeLa cells with gold nanoparticles
TAN G., SAĞLAM N., KÖPRÜ C. Z., KÖSE S., ONUR M. A., Ozcan A. G., et al.
European Biotechnology Congress, Bratislava, Slovakia, 16 - 18 May 2013, vol.24
2012
2012HOX-TALE genes show highly conserved yet heterogeneous expression profiles among fanconi anemia patients and healthy donors
ÇAĞNAN I., KONU KARAKAYALI Ö., AERTS KAYA F. S. F., KUŞKONMAZ B. B., ÇETİNKAYA F. D., ÖZCAN A.
HOX and TALE Transcription Factors in Development and Disease, Madrid, Spain, 28 November 2012 - 01 December 2010, pp.53
2012
2012Expression of HOX genes in the bone marrow derived mesenchymal stromal/stem cells from Fanconi anemia patients changes following bone marrow transplantation.
ÖZCAN A., Cagnan I., KUŞKONMAZ B. B., AERTS KAYA F. S. F., ÇETİNKAYA F. D.
ISSCR annual meeting 2012, 13 - 16 June 2012, vol.1, pp.126
2011
2011Relative gene expression analysis shows increased mRNA levels of HoxB7 and HoxA10 and decreased mRNA levels of Pbx1 in the bone marrow derived mesenchymal progenitors from Fanconi anemia patients
Ozcan A., Cagnan I., Kuskonmaz B. B., Cetinkaya D. U.
European Biotechnology Congress, İstanbul, Turkey, 28 September - 01 October 2011, vol.22
2010
2010Hastalıkta Ve Sağlıkta Mezenkimal Kök Hücrelerin MIRNA İfadeleri
ÖZCAN A., Kılıç E., AERTS KAYA F. S. F., ÇETİN M., ÇETİNKAYA F. D.
1. Uluslararası Katılımlı Kök Hücre Sempozyumu 2010, Samsun, Turkey, 29 September - 01 October 2010, pp.59
2009
2009Osteopetrosis hastalarının kemik iliği kaynaklı mezenkimal kök hücrelerinin adipojenik farklılaşmalarında rol oynayan miRNA ekspresyon profilinin saptanması.
ÖZCAN A., Kılıç E., AERTS KAYA F. S. F., ÇETİN M., ÇETİNKAYA F. D.
XI. Ulusal Tıbbi Genetik ve Biyolojisi Kongresi 2009, Turkey, 28 - 31 October 2009
2009
2009Kök Hücre Genetik Modifikasyonlarının Biyogüvenlik ve Risk Değerlendirmesi
ÖZCAN A., AERTS KAYA F. S. F., ÇETİNKAYA F. D.
1. Ulusal Hücresel Tedavi ve Rejeneratif Tıp Kongresi, Kapadokya, Turkey, 5 - 08 March 2009, pp.103
Books & Book Chapters
2021
2021Preface
Özcan A. (Editor)
in: Türkiye Klinikleri Tıbbi Genetik Özel Konular- Kök Hücre ve Rejeneratif Tıp, Ayşen Günel-Özcan, Editor, Türkiye Klinikleri Yayınevi, Ankara, 2021
2021
2021Stem Cell Genomic Stability, Cell Fate and Regeneration
Özcan A.
in: Türkiye Klinikleri Tıbbi Genetik Özel Konular- Kök Hücre ve Rejeneratif Tıp, Ayşen Günel-Özcan, Editor, Türkiye Klinikleri Yayınevi, Ankara, pp.1-9, 2021
2021
2021Empowered Mesenchymal Stem Cells with Enhanced Regenerative Capacity
Şahan Ö. B., Özcan A.
in: Kök Hücre ve Rejeneratif Tıp - 2021, Prof. Dr. Ayşen Günel Özcan, Editor, Türkiye Klinikleri Yayınevi, Ankara, pp.26-33, 2021
2008
2008Bölüm 2 Genetik Hastalıklar- Konu 13 Gen Tedavisinin Temel Prensipleri ve Klinik Uygulamaları
Özcan A.
in: İç Hastalıkları , Genel Editör: Prof. Dr. Çetin Erol Bölüm Editörü,Bölüm editörü: Prof. Dr. Işık Bökesoy, Editor, Nobel Yayın Dağıtım, Ankara, pp.103-117, 2008
Supported Projects
2023 - 2025
2023 - 2025Mezenkimal kök hücrelerde ön-koşullandırma ajanlarının antifibrotik etkilerinin miRNA ekspresyon profili ile değerlendirilmesi
Research Project of the Presidency of Turkey Health Institutes (TÜSEB)
Özcan A. (Executive)
2022 - 2024
2022 - 2024Hepatosit Büyüme Faktörü HGF İle Lisanslanmış Mezenkimal Kök Hücrelerde Antifibrotik miRNA İfade Düzeyleri
Project Supported by Higher Education Institutions
ÖZCAN A. (Executive), ALİŞAN A. B., ŞAHAN Ö. B.
2021 - 2023
2021 - 2023Kemik İliği Mezenkimal Kök Hücrelerinde p53 Yolağı Regülasyonunda PKNOX2 ve Etkileşimlerinin Araştırılması
Project Supported by Higher Education Institutions
ÖZCAN A. (Executive), Keleş M., ÇETİNKAYA F. D., ŞAHAN Ö. B.
2021 - 2023
2021 - 2023İdiyopatik Pulmoner Fibrozis İçin Yeni Tedavi Yöntemlerinin Geliştirilmesi
Research Project of the Presidency of Turkey Health Institutes (TÜSEB)
BOZKURT T. E. (Executive), DİKMEN Z. G., ÖZCAN A., DİKMEN E., ÇELTİKÇİ B., BÜBER E., et al.
2021 - 2023
2021 - 2023Effect of Reduced Bdnf Expression on Intestinal Tumorigenesis in Apc Mutant Mouse Model
TUBITAK Project
(Project Abstract)
Akyol A. (Executive), Onbaşılar İ., Özcan A., Güner G., Yılmaz E.
2019 - 2022
2019 - 2022Mezenkimal Kök Hücre Yaşlanmasında P65 ve PKNOX2 Etkileşimlerinin İncelenmesi
Project Supported by Higher Education Institutions
ÖZCAN A. (Executive), KOÇAK E., ÇETİNKAYA F. D., ŞAHAN Ö. B.
2017 - 2019
2017 - 2019
OVER KANSERLERİNDE BMP7 ve BMP2'NİN İNVAZYON VE METASTAZDAKİ ETKİSİ
Project Supported by Higher Education Institutions
ZEYBEK N. D. (Executive), TAŞAR G. E., ÖZCAN A., DOLGUN N. A., GÖK M., Bahador E., et al.
2017 - 2019
2017 - 2019Dental Pulpa Ve Kemik Iliği Kaynaklı Mezenkimal Kök Hücrelerin Osteojenik Farklılaşmasında Hypericum Perforatum Sarı Kantaron Ekstraktının Adrenerjik Reseptörler Ve Epigenetik Faktör Ezh2 Ekspresyonuna Olan Etkisinin Araştırılması TÜBİTAK 216S318
TUBITAK Project
Özcan A.
2016 - 2019
2016 - 2019Podosit Kimyasal Hasar Modeli Üzerine İndüklenmiş Mezenkimal Kök Hücrelerin Etkisi
Project Supported by Higher Education Institutions
ÖZCAN A. (Executive), GÜÇER K. Ş., ONBAŞILAR İ., ŞAHAN Ö. B., KORKMAZ E.
2016 - 2018
2016 - 2018Generation of Murine Intestinal Polyposis Model with CRISPR/Cas9 System
TUBITAK Project
AKYOL A. (Executive), ONBAŞILAR İ., ÖZCAN A.
2015 - 2018
2015 - 2018Fankoni Anemisi Kemik İliği Mezenkimal Kök Hücrelerinde HOX ve TALE Transkripsiyon Faktörleri Gen İfadeleri ve Protein Etkileşimleri TUBITAK 1001 214Z033
TUBITAK Project
ÖZCAN A. (Executive), ŞAHAN Ö. B.
2016 - 2017
2016 - 2017Hacettepe Üniversitesi Ar Ge Strateji Belgesi Rejeneratif ve Restoratif Tıp
TUBITAK Project
Çetinkaya F. D., Çelebi Saltık B., Vargel İ. (Executive), Okur F. V., Korkusuz P., Özcan A.
2016 - 2016
2016 - 2016Avrupa Gen ve Hücresel Tedaviler Derneği (ESGCT) ve Uluslararası kök hücre araştırma derneği (ISSCR) birleşik Kongresi 2016 Floransa
Project Supported by Higher Education Institutions
ÖZCAN A. (Executive)
2015 - 2016
2015 - 2016Kök Hücre Günü 2015
Project Supported by Higher Education Institutions
AERTS KAYA F. S. F. (Executive), ÇETİNKAYA F. D., ÖZCAN A., ÇELEBİ SALTIK B.
2015 - 2016
2015 - 2016IN VIVO GCSF UYGULAMASININ SAĞLIKLI DONORLERİN KEMİK İLİĞİ KAYNAKLI MEZENKİMAL KÖK HÜCRE miRNA İFADELERİ ÜZERİNE ETKİSİ
Project Supported by Higher Education Institutions
ÖZCAN A. (Executive), ÇETİNKAYA F. D., ŞAHAN Ö. B.
2010 - 2016
2010 - 2016Advanced Cell-based Therapies for the treatment of Primary ImmunoDeficiency
EU Framework Program Project
ÖZCAN A.
2015 - 2015
2015 - 2015ESGCT and FSGT Collaborative Congress Helsinki Finlandiya kongre katılım
Project Supported by Higher Education Institutions
ÖZCAN A. (Executive)
2012 - 2014
2012 - 2014Glukokortikoid ile İndüklenen TNFR Protein Ligandı (GITRL) Transfekte Edilmiş Mezenkimal Kök Hücrelerin (MKH) Akciğer Kanserine Etkisi
TUBITAK Project
ÖZCAN A. (Executive)
2010 - 2014
2010 - 2014HOX/TALE genlerinin Kemik İliği Nakli Yapılan Fanconi Anemisi Hastalarının Kemik İliği Mezenkimal Kök Hücrelerindeki Ekspresyon Profillerinin Saptanması ve HOX/TALE Regülasynunda Rol oynayan Tüm Genom miRNA Ekspresyon Mikroarray Korelasyonlarının Araştırılmas
EU Supported Other Project
ÖZCAN A. (Executive)
2006 - 2010
2006 - 2010PEDI-STEM Kök hücre araştırma, geliştirme ve hücresel tedavi merkezi oluşturma
CB Strateji ve Bütçe Başkanlığı (Kalkınma Bakanlığı) Projesi
ÖZCAN A.
2004 - 2005
2004 - 2005Kimyasal karsinojenez ile oluşturulmuş rat meme adenokarsinom hücrelerinde CD40L geninin klonlanması ve ex-vivo immün yanıtın karakterizasyonu
Project Supported by Other Private Institutions
ÖZCAN A. (Executive)
Memberships / Tasks in Scientific Organizations
2018 - Continues
2018 - ContinuesTürkiye Solunum Araştırmaları Derneği
Member
2017 - Continues
2017 - ContinuesISEH
Member
2014 - Continues
2014 - ContinuesESGCT
Member
2012 - Continues
2012 - ContinuesISSCR
Member
2010 - Continues
2010 - ContinuesTıbbi Biyoloji ve Genetik
Member
2000 - Continues
2000 - ContinuesTıbbi Genetik
Member
Awards
October 2018
October 2018“Prof. Dr. Meliha Terzioğlu Bilim Ödülü”
Türkiye Solunum Araştırmaları Derneği
March 2014
March 20141. Uluslararası Katılımlı Kök Hücre ve Hücresel Tedaviler Kongresi en iyi ikinci poster ödülü
Kök Hücre ve Hücresel Tedaviler Derneği
June 2012
June 2012ISSCR 2012 10th Annual Meeting Travel Award
ISSCR
April 2007
April 2007Prof. Dr. Bedii Gorbon ödülü
XVII. Ulusal Kanser Kongresi
October 2006
October 2006
1. Multidisipliner Kanser Araştırmaları Sempozyumu En iyi Poster Ödülü 2006
MOKAD
October 2005
October 20051. Moleküler Tıp Kongresi en iyi ikinci poster ödülü
Moleküler Tıp Derneği
October 2003
October 200313th Balkan Biochemical Biophysical Days & Meeting on Metabolic Disorders Poster Mansion Award
Türk Biyokimya Derneği
June 1991
June 1991Merkez Sağlık Ocağı Tabibi takdirnamesi
Şarkışla Kaymakamı
Invited Talks
September 2023
September 2023Adenoassosiye Virüs Tabanlı Gen Tedavilerinde Güncel Gelişmeler ve Rekombinant AAV'lerde Yeni Ufuklar, Yeni Nesil Gen ve Hücre Tedavi Uygulamaları Paneli - 1 30 Eylül 2023 BioTürkiye Uluslararası BiyoTeknoloji Kongresi 28-30 Eylül 2023, Osmanlı Külliyesi İstanbul
Conference
BioTürkiye International Biotechnology Congress-2023-Turkey
November 2022
November 2022Köklere dönüyor muyuz? İPF, KOAH ve ARDS’de kök hücre tedavisi 6 Kasım 2022 TÜSAD 44. Uluslararası Katılımlı Yıllık Kongresi - "SOLUNUM 2022"
Conference
Türkiye Solunum Araştırmaları Derneği -Turkey
November 2019
November 2019‘Rekombinant Hücre ve GenTeknolojileri: Viral Vektörler’ 28 Kasım 2019 ‘ileri Tedavi Tıbbi Ürünleri’ II. Farmasötik Biyoteknoloji Çalıştayı
Workshop
Farmasötik Biyoteknoloji Derneği-Turkey
February 2019
February 2019Kanser Tedavisinde Kök Hücreler, IV. Hacettepe Biyoloji ve Uygulamaları Kongresi (4-6 Şubat 2019)
Conference
Hacettepe Üniversitesi-Turkey
August 2017
August 2017Adult Stem Cells and Cancer: Is There a Link? 21 Ağustos 2017 SYNAPSIST’17 Summer School WITH A NEW TOPIC: CANCER
Conference
Koç Üniversitesi-Turkey
April 2017
April 2017Gen Aktarım Platformu Olarak Mezenkimal Kök Hücreler, İstanbul Üniversitesi 2. Kök Hücre ve Uygulamaları Sempozyumu Cemil Birsel Oditoryumu 29.04.2017
Conference
İstanbul Üniversitesi-Turkey
April 2017
April 2017Genom Çağında Moleküler Kanser Biyolojisi, Carcinos ‘Kanser’ Sempozyumu 9 Nisan 2017
Conference
Gazi Üniversitesi-Turkey
March 2017
March 2017Dünden Bugüne Kök Hücre Araştırmaları, Uşak Üniversitesi Biyolojik Bilimler ve Biyoteknoloji Topluluğu Konferansları-I 10 Mart 2017
Conference
Uşak Üniversitesi-Turkey
November 2016
November 2016Fanconi anemisinde Kemik iliği mezenkimal kök hücrelerinin HOX/TALE kimliği ve Fizyopatolojik önemi’ . Hacettepe Üniversitesi ‘Kök Hücre Günü 2016'
Conference
Hacettepe Üniversitesi-Turkey
February 2016
February 2016Kök Hücreler ile İmmunomodülasyon, 3 Şubat 2016 Hitit Üniversitesi Çorum
Conference
Hitit Üniversitesi-Turkey
April 2015
April 2015KOAH da Kök Hücre Tedavisi, Türk Toraks Derneği 18. Yıllık Kongresi
Conference
Türk Toraks Derneği-Turkey
February 2014
February 2014Doku Kimliğinin Belirlenmesinde HOX Kodları ve Rejeneratif Tıpta Önemi, 4. Ulusal Hücresel Tedavi ve Rejeneratif Tıp Kongresi
Conference
Ulusal Hücresel Tedavi ve Rejeneratif Tıp Derneği-Turkey
October 2013
October 2013HOX-TALE expression patterns in Fanconi anemia, Meeting for HOX and TALE TFs in Development and Disease (COST Action BM0805 Meeting), 04.10.2013, Egmond aan Zee
Conference
COST ACTION BM0805 Meeting-Netherlands
September 2011
September 2011HOX-TALE expression in bone marrow derived mesenchymal stromal cells of Fanconi anemia patients 30.09. 2011 COST BM0805 Meeting, Carry-Le-Rouet. Marsilya
Conference
COST BM0805 Meeting-France
September 2010
September 2010Hastalıkta ve Sağlıkta Mezenkimal Kök Hücrelerin miRNA ifadeleri, 1. Uluslarası katılımlı kök hücre sempozyumu, Samsun
Conference
1. Uluslarası katılımlı Kök Hücre Sempozyumu, Samsun-Turkey
July 1996
July 1996Dehydroquinate synthase as a possible target for developing new antimicrobial agents, IUMS Congresses 96, 8th International Congress of Bacteriology and Applied Microbiology Division
Conference
IUMS -Israel
Scholarships
2003 - 2003
2003 - 2003EMBO SAGE Course Amsterdam
Other International Organizations
1994 - 1997
1994 - 1997