From Stem Cell Biology to The Treatment of Lung Diseases

Esendagli D., Gunel-Ozcan A.

CURRENT STEM CELL RESEARCH & THERAPY, vol.12, no.6, pp.493-505, 2017 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 12 Issue: 6
  • Publication Date: 2017
  • Doi Number: 10.2174/1574888x12666170523155846
  • Journal Name: CURRENT STEM CELL RESEARCH & THERAPY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.493-505
  • Keywords: Stem cells, lung regeneration, lung diseases, cell therapy, clinical trial, cancer stem cell, OBSTRUCTIVE PULMONARY-DISEASE, MOUSE LUNG, PROGENITOR CELLS, CILIATED CELLS, BETA-CATENIN, CLARA CELLS, ADULT LUNG, AIRWAY, REGENERATION, DIFFERENTIATION
  • Hacettepe University Affiliated: Yes

Abstract

Background: The exposure of lung to noxious agents or gasses leads to injury, which further enhances repair mechanisms by promoting the proliferation and differentiation of lung stem cells. These cells could help preserve the anatomical structure and the function of the organ. Unfortunately in many lung diseases, 'this scenario' is changed and injury progresses despite repair mechanisms or conventional treatment.