HFE H63D mutation frequency shows an increase in Turkish women with breast cancer

Gunel-Ozcan, AYŞEN; ALYILMAZ-BEKMEZ, S; GULER, EN; GUC, DİCLE

doi:10.1186/1471-2407-6-37

HFE H63D mutation frequency shows an increase in Turkish women with breast cancer

Gunel-Ozcan A., ALYILMAZ-BEKMEZ S., GULER E., GUC D.

BMC CANCER, cilt.6, 2006 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 6
Basım Tarihi: 2006
Doi Numarası: 10.1186/1471-2407-6-37
Dergi Adı: BMC CANCER
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Hacettepe Üniversitesi Adresli: Evet

Özet

Background: The hereditary hemochromatosis gene HFE plays a pivotal role in iron homeostasis. The association between cancer and HFE hetero- or homozygosity has previously been shown including hepatocellular and nonhepatocellular malignancies. This study was performed to compare frequencies of HFE C282Y and H63D variants in Turkish women with breast cancer and healthy controls.