Adhesion of beta1 integrin to fibronectin regulates CAM-DR phenotype via p21(WAF1/cip1) in HL60 acute myeloid leukemia (AML) cells


CANPINAR H., ESENDAĞLI G., Kansu E., Ozcan A. G. , Guc D.

TURKISH JOURNAL OF MEDICAL SCIENCES, vol.38, no.2, pp.97-104, 2008 (Peer-Reviewed Journal) identifier

  • Publication Type: Article / Article
  • Volume: 38 Issue: 2
  • Publication Date: 2008
  • Journal Name: TURKISH JOURNAL OF MEDICAL SCIENCES
  • Journal Indexes: Science Citation Index Expanded, Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.97-104

Abstract

Aims: Drug resistance is a major obstacle for a successful cancer therapy. Cell adhesion mediated drug resistance (CAM-DR) is a novel type of drug resistance and generated via interaction of cancer cells with the microenvironment. In this study, CAM-DR phenotype was analyzed in HL60 acute myeloid leukemia (AML) cells.