FMF and autoInflammation REsearch group (FIRE)

WELCOME TO FMF AND AUTOINFLAMMATION RESEARCH GROUP (FIRE)
Systemic Autoinflammatory Diseases (SAIDs) are caused by mutations in genes that encode interleukin 1 related proteins. Familial Mediterranean fever (FMF) is the most common autoinflammatory disease seen worldwide but is especially prevalent in Eastern Mediterranean countries including Turkey. Our group, named recently as FIRE group has been studying on SAIDs and mainly FMF for a long time. Group studies are divided into three main branches; genetic etiology of these diseases, inflammasome biology, and epigenetic mechanisms (mainly non-coding RNAs). Our side projects include a wide range of conditions where inflammation is a component in the disease progression such as Behçet’s Disease and Parkinson’s Disease.As a research group that mainly focuses on the molecular biology of autoinflammatory disorders, we believe that elucidation of the key mechanisms related to inflammation will lead to improved knowledge about numerous genetic autoinflammatory diseases.


Haberler

7 Aralık 2022

2022-2023 Fall Term Master/Ph.D. Application Announcement

Son Eklenen Yayınlar

Exploring regulatory mechanisms on miRNAs and their implications in inflammation-related diseases.

Nalbant E., Akkaya-Ulum Y. Z.
Clinical and experimental medicine, cilt.24, sa.1, ss.142, 2024 (SCI-Expanded)

NELL 1 and BMP 2 loaded chitosan HA SCAFFOLD

AKMAN A. C., Demirtaş T. T., AKKAYA ULUM Z. Y., Büyüközdemir S., YILMAZ E., GÜMÜŞDERELİOĞLU M., et al.
Europerio 8, 3 - 06 Haziran 2015, cilt.42, ss.252-253

Anti-LAMP-2 Antibody Seropositivity in Children with Primary Systemic Vasculitis Affecting Medium- and Large-Sized Vessels

AKBABA T. H., Toor K. K., Mann S. K., Gibson K. M., Alfaro G. A., Balci-Peynircioglu B., et al.
International Journal of Molecular Sciences, cilt.25, sa.7, 2024 (SCI-Expanded)

Genetic variations in Familial Mediterranean fever related MIR197 gene in Turkish population Türk popülasyonundaki Ailevi Akdeniz ateşi ilişkili MIR197 genindeki genetik varyasyonlar

Nalbant E., Şen B., KILIÇ L., AKKAYA ULUM Z. Y.
Journal of Turkish Society For Rheumatology, cilt.16, sa.1, ss.38-43, 2024 (Scopus)

InflammamiRs in focus: Delivery strategies and therapeutic approaches

AKKAYA ULUM Z. Y., Sen B., AKBABA T. H., Balci-Peynircioglu B.
FASEB Journal, cilt.38, sa.5, 2024 (SCI-Expanded)

The role of telocytes and miR-21-5p in tumorigenicity and metastasis of breast cancer stem cells

Babadağ S., Altundağ Ö., Akkaya Ulum Z. Y., Çelebi Saltık B.
MOLECULAR BIOLOGY REPORTS, cilt.51, sa.1, ss.395-408, 2024 (SCI-Expanded)

Cellular models in autoinflammatory disease research

Şen B., Balcı-Peynircioğlu B.
Clinical and Translational Immunology, cilt.13, sa.1, 2024 (SCI-Expanded)

Characterization of serum extracellular vesicles and their differential level of miR-197-3p in familial Mediterranean fever patients

Tavukcuoglu Z., AKKAYA ULUM Z. Y., YERSAL N., Horzum U., AKBABA T. H., KARADAĞ Ö., et al.
Nucleosides, Nucleotides and Nucleic Acids, 2023 (SCI-Expanded)

Behçet’s syndrome: recent advances to aid diagnosis

AKBABA T. H., EKİCİ M., Çolpak A. İ., Brown K. L., KARADAĞ Ö., Balci-Peynircioglu B.
Clinical and Experimental Medicine, cilt.23, sa.8, ss.4079-4090, 2023 (SCI-Expanded)

Drug metabolism and inflammation related distinct miRNA signature of colchicine resistant familial Mediterranean fever patients

Tümerdem B. Ş., AKBABA T. H., BATU AKAL E. D., AKKAYA ULUM Z. Y., MUTLU P., ÖZEN S., et al.
International Immunopharmacology, cilt.124, 2023 (SCI-Expanded)