Behçet’s syndrome: recent advances to aid diagnosis


AKBABA T. H., EKİCİ M., Çolpak A. İ., Brown K. L., KARADAĞ Ö., Balci-Peynircioglu B.

Clinical and Experimental Medicine, cilt.23, sa.8, ss.4079-4090, 2023 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 23 Sayı: 8
  • Basım Tarihi: 2023
  • Doi Numarası: 10.1007/s10238-023-01226-7
  • Dergi Adı: Clinical and Experimental Medicine
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database
  • Sayfa Sayıları: ss.4079-4090
  • Anahtar Kelimeler: Behçet’s syndrome, Epidemiology, Immunopathogenesis, Molecular diagnosis
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Behçet’s syndrome is a recurring inflammatory multiorgan disorder affecting the skin, mucosa, eyes, joints, stomach, and central nervous system. Behçet’s syndrome epidemiology varies greatly among populations (0.64–420/100,000), and Behçet’s syndrome has gained increasing international acclaim in the recent 50 years due to raising awareness of the syndrome, although it is rare in most population. In addition to the unclear etiology of the syndrome, the diagnosis of Behçet’s syndrome is complicated by a vague clinical presentation, phenotypic heterogeneity and/or incomplete representation, and the lack of any specific laboratory, radiographic, or histological findings. There exists a dire need to elucidate factors that contribute to disease pathogenesis and/or are associated with clinical features of Behçet’s syndrome and the classification of different forms of the syndrome. The identification of such molecular, cellular, and/or clinical factors are crucial for timely diagnosis and efficacious management of Behçet’s syndrome. We discuss recent advances in the clinical diagnosis of Behçet’s syndrome and related contributions of genetics, epigenetics, microbiome, inflammasomes, and autoantibodies to the improved diagnosis, management, and understanding of Behçet’s syndrome.