Cellular models in autoinflammatory disease research


Şen B., Balcı-Peynircioğlu B.

Clinical and Translational Immunology, vol.13, no.1, 2024 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Review
  • Volume: 13 Issue: 1
  • Publication Date: 2024
  • Doi Number: 10.1002/cti2.1481
  • Journal Name: Clinical and Translational Immunology
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Keywords: autoinflammation, disease modelling, induced pluripotent stem cell, systemic autoinflammatory diseases
  • Hacettepe University Affiliated: Yes

Abstract

Systemic autoinflammatory diseases are a heterogeneous group of rare genetic disorders caused by dysregulation of the innate immune system. Understanding the complex mechanisms underlying these conditions is critical for developing effective treatments. Cellular models are essential for identifying new conditions and studying their pathogenesis. Traditionally, these studies have used primary cells and cell lines of disease-relevant cell types, although newer induced pluripotent stem cell (iPSC)-based models might have unique advantages. In this review, we discuss the three cellular models used in autoinflammatory disease research, their strengths and weaknesses, and their applications to inform future research in the field.