Education
2007 - 2012
2007 - 2012Doctorate
University of Florida, College Of Liberal Arts And Sciences, Chemistry, United States Of America
2004 - 2007
2004 - 2007Postgraduate
Hacettepe University, Fen Bilimleri Enstitüsü, Kimya , Turkey
1999 - 2004
1999 - 2004Undergraduate
Hacettepe University, Fen Fakültesi, Kimya, Turkey
Dissertations
2012
2012Doctorate
Aptamer based affinity methods for mass spectrometry
University Of Florida, Chemistry
2007
2007Postgraduate
Investigation of noncovalent protein-protein interactions by matrix-assisted laser desorption/ionization mass spectrometry
Hacettepe Üniversitesi, Fen Bilimleri Enstitüsü, Kimya (Yl) (Tezli)
Research Areas
Life Sciences
Biochemistry
Metabolism
Chemistry
Analytical Chemistry
Bioanalytical Methods
Chromatographic Analysis
Mass Spectroscopy
Physical Chemistry
nanocomposites
Natural Sciences
Academic Positions
2014 - Continues
2014 - ContinuesAssociate Professor
Hacettepe University, Çocuk Sağlığı Enstitüsü, Pediatrik Temel Bilimler A.B.D.
2012 - 2014
2012 - 2014Lecturer PhD
Eidgenössische Technische Hochschule, ETHZ (The Federal Institute of Technology, Zürich), Chemistry And Applied Biosciences, Chemistry And Applied Biosciences
2007 - 2012
2007 - 2012Research Assistant
University of Florida, Liberal Arts And Sciences, Chemistry
2005 - 2007
2005 - 2007Research Assistant
Hacettepe University, Fen Fakültesi, Kimya Bölümü
Journal articles indexed in SCI, SSCI, and AHCI
2024
2024Exploring metabolic alterations in PYCR2 deficiency: Unveiling pathways and clinical presentations of hypomyelinating leukodystrophy 10
Gurbuz B. B., GÜLBAKAN B., ÖZGÜL R. K., YALNIZOĞLU D., Yilmaz D. Y., GÖÇMEN R., et al.
AMERICAN JOURNAL OF MEDICAL GENETICS PART A
, vol.194, no.9, 2024 (SCI-Expanded)
2022
2022An investigation of different intracellular parameters for Inborn Errors of Metabolism: Cellular stress, antioxidant response and autophagy
Vardar Acar N., DURSUN A., Aygün D., Gürses Cila H. E., LAY İ., GÜLBAKAN B., et al.
Free Radical Biology and Medicine
, vol.179, pp.190-199, 2022 (SCI-Expanded)
2021
2021Biallelic mutations in ELFN1 gene associated with developmental and epileptic encephalopathy and joint laxity
DURSUN A., YALNIZOĞLU D., Yilmaz D. Y., Oguz K. K., GÜLBAKAN B., KOŞUKCU C., et al.
EUROPEAN JOURNAL OF MEDICAL GENETICS
, vol.64, no.11, 2021 (SCI-Expanded)
2018
2018Native Electrospray Ionization Mass Spectrometry Reveals Multiple Facets of Aptamer-Ligand Interactions: From Mechanism to Binding Constants
Gulbakan B., Barylyuk K., Schneider P., Pillong M., Schneider G., Zenobi R.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
, vol.140, no.24, pp.7486-7497, 2018 (SCI-Expanded)
2016
2016Discovery of biomarkers in rare diseases: innovative approaches by predictive and personalized medicine
GÜLBAKAN B., ÖZGÜL R. K., YÜZBAŞIOĞLU A., Kohl M., Deigner H., ÖZGÜÇ M.
EPMA JOURNAL
, vol.7, 2016 (SCI-Expanded)
2016
2016Generation of Fluorogen-Activating Designed Ankyrin Repeat Proteins (FADAs) as Versatile Sensor Tools
Schutz M., Batyuk A., Klenk C., Kummer L., de Picciotto S., Gulbakan B., et al.
JOURNAL OF MOLECULAR BIOLOGY
, vol.428, no.6, pp.1272-1289, 2016 (SCI-Expanded)
2016
2016Applying mass spectrometry to study non-covalent biomolecule complexes
Chen F., GÜLBAKAN B., Weidmann S., Fagerer S. R., Ibanez A. J., Zenobi R.
MASS SPECTROMETRY REVIEWS
, vol.35, no.1, pp.48-70, 2016 (SCI-Expanded)
2015
2015Influence of Ammonium Acetate Concentration on Receptor Ligand Binding Affinities Measured by Native Nano ESI-MS: A Systematic Study
Gavriilidou A. F. M., GÜLBAKAN B., Zenobi R.
ANALYTICAL CHEMISTRY
, vol.87, no.20, pp.10378-10384, 2015 (SCI-Expanded)
2015
2015Determination of thermodynamic and kinetic properties of biomolecules by mass spectrometry
Guelbakan B., BARYLYUK K., ZENOBI R.
CURRENT OPINION IN BIOTECHNOLOGY
, vol.31, pp.65-72, 2015 (SCI-Expanded)
2015
2015Oligonucleotide aptamers: emerging affinity probes for bioanalytical mass spectrometry and biomarker discovery
Gulbakan B.
ANALYTICAL METHODS
, vol.7, no.18, pp.7416-7430, 2015 (SCI-Expanded)
2014
2014Post-Genomics Nanotechnology Is Gaining Momentum: Nanoproteomics and Applications in Life Sciences
KOBEISSY F. H., Gulbakan B., ALAWIEH A., KARAM P., ZHANG Z., GUINGAB-CAGMAT J. D., et al.
OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY
, vol.18, no.2, pp.111-131, 2014 (SCI-Expanded)
2013
2013DNA Oligonucleotides: A Model System with Tunable Binding Strength to Study Monomer-Dimer Equilibria with Electrospray Ionization-Mass Spectrometry
BARYLYUK K., Guelbakan B., Xie X., ZENOBI R.
ANALYTICAL CHEMISTRY
, vol.85, no.24, pp.11902-11912, 2013 (SCI-Expanded)
2013
2013DNA-Guided Metal-Nanoparticle Formation on Graphene Oxide Surface
OCSOY I., Gulbakan B., CHEN T., ZHU G., CHEN Z., SARI M. M., et al.
ADVANCED MATERIALS
, vol.25, no.16, pp.2319-2325, 2013 (SCI-Expanded)
2013
2013Aptamer-Conjugated Multifunctional Nanoflowers as a Platform for Targeting, Capture, and Detection in Laser Desorption Ionization Mass Spectrometry
OCSOY I., Gulbakan B., SHUKOOR M. I., XIONG X., CHEN T., POWELL D. H., et al.
ACS NANO
, vol.7, no.1, pp.417-427, 2013 (SCI-Expanded)
2013
2013Direct access to aptamer-protein complexes via MALDI-MS
CHEN F., Guelbakan B., ZENOBI R.
CHEMICAL SCIENCE
, vol.4, no.10, pp.4071-4078, 2013 (SCI-Expanded)
2012
2012A Logical Molecular Circuit for Programmable and Autonomous Regulation of Protein Activity Using DNA Aptamer-Protein Interactions
HAN D., ZHU Z., WU C., PENG L., ZHOU L., Gulbakan B., et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
, vol.134, no.51, pp.20797-20804, 2012 (SCI-Expanded)
2012
2012Enrichment and Detection of Rare Proteins with Aptamer-Conjugated Gold Nanorods
YASUN E., Gulbakan B., OCSOY I., YUAN Q., SHUKOOR M. I., LI C., et al.
ANALYTICAL CHEMISTRY
, vol.84, no.14, pp.6008-6015, 2012 (SCI-Expanded)
2011
2011Aptamers: turning the spotlight on cells
LOPEZ-COLON D., JIMENEZ E., YOU M., Gulbakan B., TAN W.
WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY
, vol.3, no.3, pp.328-340, 2011 (SCI-Expanded)
2011
2011In Vitro Selection of DNA Aptamers to Glioblastoma Multiforme
BAYRAC A. T., SEFAH K., PAREKH P., BAYRAC C., Gulbakan B., ÖKTEM H. A., et al.
ACS CHEMICAL NEUROSCIENCE
, vol.2, no.3, pp.175-181, 2011 (SCI-Expanded)
2011
2011Aptamer-conjugated nanomaterials for bioanalysis and biotechnology applications
CHEN T., SHUKOOR M. I., CHEN Y., YUAN Q., ZHU Z., ZHAO Z., et al.
NANOSCALE
, vol.3, no.2, pp.546-556, 2011 (SCI-Expanded)
2010
2010A Dual Platform for Selective Analyte Enrichment and Ionization in Mass Spectrometry Using Aptamer-Conjugated Graphene Oxide
Gulbakan B., YASUN E., SHUKOOR M. I., ZHU Z., YOU M., Tan X., et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
, vol.132, no.49, pp.17408-17410, 2010 (SCI-Expanded)
2010
2010Pyrene-Assisted Efficient Photolysis of Disulfide Bonds in DNA-Based Molecular Engineering
YOU M., ZHU Z., LIU H., Gulbakan B., HAN D., WANG R., et al.
ACS APPLIED MATERIALS & INTERFACES
, vol.2, no.12, pp.3601-3605, 2010 (SCI-Expanded)
2008
2008Preconcentration and matrix elimination for the determination of Pb(II), Cd(II), Ni(II), and Co(II) by 8-hydroxyquinoline anchored poly(styrene-divinylbenzene) microbeads
ASKUN H., GÜLBAKAN B., ÇELİKBIÇAK Ö., UZUN C., GUVEN G., SALİH B.
JOURNAL OF APPLIED POLYMER SCIENCE
, vol.107, no.4, pp.2714-2722, 2008 (SCI-Expanded)
2008
2008Solid phase extraction of organochlorine pesticides with modified poly (styrene-divinylbenzene) microbeads using home-made solid phase extraction syringes
Guelbakan B., UZUN C., CELIKBICAK O., GUEVEN G., SALİH B.
REACTIVE & FUNCTIONAL POLYMERS
, vol.68, no.2, pp.580-593, 2008 (SCI-Expanded)
Papers Presented at Peer-Reviewed Scientific Conferences
2019
2019Niş benzeri Kokültür sistemi ile AML lösemik kök hücrelerinin tanımlanması ve karakterizasyonu.
alkan b., cevher i., GÜLBAKAN B., AYTAÇ EYÜPOĞLU Ş. S., uçkan çetinkaya f. d.
45. ulusal hematoloji kongresi, Turkey, 30 October - 02 November 2019, (Summary Text)
2019
2019Niş benzeri kokültür sistemi ile AML lösemik kök hücrelerin tanımlanması ve karekterizasyonu
Alkan B., Cevher I., GÜLBAKAN B., AYTAC Ş. S., CETINKAYA D., OKUR F. V.
45. Ulusal Hematoloji Kongresi, Antalya, Turkey, 30 October - 02 November 2019, (Full Text)
2017
2017KOVALENT OLMAYAN RESEPTÖR-LİGAND ETKİLEŞİMLERİNİN ANALİZİNDE BİYOANALİTİK KÜTLE SPEKTROMETRİ TEKNİKLERİNİN KULLANIMI
GÜLBAKAN B.
ULUSAL KİMYA KONGRESİ, Turkey, 10 - 14 September 2017, (Summary Text)
2017
2017APTAMERLER VE BIYOMEDIKAL UYGULAMALARI
GÜLBAKAN B.
’xxUygulamalı Biyokimya’xxda Güncel Konular’xx YAZ OKULU, Turkey, 12 - 14 July 2017, (Summary Text)
2017
2017Klinik UygulamalardaMetabolomik
GÜLBAKAN B.
14. Ulusal Metabolik Hastalıklar ve Beslenme Kongresi, Turkey, 26 - 30 April 2017, (Summary Text)
2016
2016METABOLİK NÖROMETABOLİK HASTALIKLARDA BİYOBELİRTEÇLER
GÜLBAKAN B.
III. NÖROMETABOLİK DİSMORFOLOJİ SEMPOZYUMU, Turkey, 10 - 12 March 2016, (Summary Text)
2015
2015Oligonucleotide aptamers emerging affinity probes for bioanalytical mass spectrometry and biomarker discovery
GÜLBAKAN B.
GPSS 2015, 12 - 15 November 2015
2015
2015Aptamer conjuagated nanostructures for affinity mass spectrometry
GÜLBAKAN B., ÖÇSOY İ.
NanoTr 2015, 22 - 25 June 2015
2015
2015Aptamer based affinity mass spectrometry
GÜLBAKAN B.
2nd International Congress on Biosensors, 10 - 12 June 2015
2014
2014soft ionization mass spectrometry studies of aptamer ligand complexes
GÜLBAKAN B., Barylyuk K., chen f., zenobi r.
4th Symposium on Structural Proteomics, 27 - 28 November 2014
2014
2014Native nano ESI mass spectrometry studies ofaptamer ligand complexes
GÜLBAKAN B., Barylyuk K., zenobi r.
IMSC 2014, 24 - 29 August 2014
2014
2014Effect of Buffer Concentration on Protein LigandBinding Affinities Measured by Native ESI MS
Gavriilidou A. F. M., GÜLBAKAN B., Zenobi R.
IMSC 2014, 24 - 29 August 2014
2013
2013probing aptamer ligand interactions by soft ionization mass spectrometry methods
GÜLBAKAN B., barylyuk k., chen f., zenobi r.
61th ASMS Annual Conference, 9 - 13 June 2013
2012
2012Pyrene 1 Boronic Acid Conjugated Magnetic Graphene Oxide a New Material for Glycoprotein Capturing
ÖÇSOY İ., GÜLBAKAN B., GÖKTÜRK E., ERDAL H., sena c., öçsoy m., et al.
5th NanoFlorida Conference, 29 - 30 September 2012
2012
2012Surface Modification of Aptamer Conjugated Gold Silver Nanorods for Rare Protein Detection
yasun e., GÜLBAKAN B., tan w.
The Pittsburgh Conference on Analytical Chemistry and Applied Spectroscopy, 11 - 15 March 2012
2012
2012Photochemical Protein Scissors DNA Aptamer for Target Selective and Site Specific Cleavage of PDGF
you m., cansız s., odonoughe m., GÜLBAKAN B., tan w.
The Pittsburgh Conference on Analytical Chemistry and Applied Spectroscopy, 11 - 15 March 2012
2012
2012Hybrid Nanoflowers Single Platform For Targeting Metabolite Sensing and Analysis
ÖÇSOY İ., GÜLBAKAN B., shukoor m. i., xiong x., yasun e., tan w.
The Pittsburgh Conference on Analytical Chemistry and Applied Spectroscopy, 11 - 15 March 2012
2011
2011Aptamer conjugated Gold Silver Nanorods for Rare Protein Enrichment and Detection
yasun e., GÜLBAKAN B., shukoor m. i., ÖÇSOY İ.
4th NanoFlorida Conference, 30 September - 01 October 2011
2011
2011A Dual Mass Spectrometry Platform Based on Aptamer Conjugated Graphene Oxide
GÜLBAKAN B., yasun e., shukoor m. i., powell d. h., tan w.
59th ASMS Annual Conference, 5 - 09 June 2011
2011
2011Graphene oxide aptamer Conjugates as MALDI MS Matrix for Biomolecule Analysis
yasun e., GÜLBAKAN B., tan w.
“The Pittsburgh Conference on Analytical Chemistry and Applied Spectroscopy, 13 - 18 March 2011
2011
2011Raman Active Au FePt Hybrid Nanoparticles for Rare Protein Isolation and Quantification
ÖÇSOY İ., shukoor m. i., GÜLBAKAN B., tan w.
The Pittsburgh Conference on Analytical Chemistry and Applied Spectroscopy, 13 - 18 March 2011
2010
2010Direct Analysis in Real Time Mass Spectrometry of High Molecular Weight Organometallic Porphyrins
GÜLBAKAN B., sommers j., rummel j., schanze k., powell d. h., tan w.
58th ASMS Annual Conference, 23 - 27 May 2010
2010
2010Aptamer Based Affinity Capture Arrays
GÜLBAKAN B., BAYRAÇ A. T., kim y., philips j. a., tan w.
The Pittsburgh Conference on Analytical Chemistry and Applied Spectroscopy, 28 February - 04 March 2010
2009
2009laser desorption ionization on silicon nanowell arrays prepared by argon plasma etching using a nanoporous alumina mask
GÜLBAKAN B., park d., KEÇECİ K., martin c. R., powell d. h., tan w.
57th ASMS Annual Conference, 31 May - 05 June 2009
2009
2009MALDI MS probing of non covalent protein complexes related to Alzheimer s disease
GÜLBAKAN B., SALİH B.
57th ASMS Annual Conference, 31 May - 05 June 2009
2007
2007INVESTIGATION OF NONCOVALENT PROTEIN PROTEIN INTERACTIONS BY MATRIX ASSISTED LASER DESORPTION IONIZATION MASS SPECTROMETRY
SALİH B., GÜLBAKAN B., demirel ö.
INTERNATIONAL SYMPOSIUM on DRUG RESEARCH and DEVELOPMENT“From Chemistry to Medicine”, Turkey, 17 - 20 May 2007
2007
2007DEVELOPMENT AND OPTIMIZATION OF A SURFACE AIDED ENZYMATIC DIGESTION SYSTEM TO USE IN PROTEOMICS STUDIES
GÜLBAKAN B., öztürk çal a., YALÇIN T., SALİH B.
INTERNATIONAL SYMPOSIUM on DRUG RESEARCH and DEVELOPMENT“From Chemistry to Medicine”, 17 - 20 May 2007
2005
2005POLİ STİREN DİVİNİLBENZEN MİKROKÜRELERİNİN 8HQ İLE MODİFİKASYONUYLA Cd II Pb II Ni II Co II METALLERİNİN UZAKLAŞTIRILMASI VE ZENGİNLEŞTİRİLMESİ
aşkun h., GÜLBAKAN B., UZUN C., ÇELİKBIÇAK Ö., SALİH B., güven o.
XIX. Ulusal Kimya Kongresi, Ege Üniversitesi, Turkey, 30 September - 04 October 2005
2005
2005POLİ STİREN DİVİNİLBENZEN MİKROKÜRELERİNİN NH2 8HQ VE COOH İLE MODİFİKASYONU VE AĞIR METALLERİN KATI FAZ EKSTRAKSİYONU İÇİN KULLANIMI
GÜLBAKAN B., UZUN C., ÇELİKBIÇAK Ö., güven o., SALİH B.
XIX. Ulusal Kimya Kongresi, Turkey, 30 September - 04 October 2005
Funded Projects
2019 - 2022
2019 - 2022Galaktozemi ve Akçağaç Şurubu Hastalarında İnflamasyon İlişkisinin Hedefsiz Metabolomik İle Araştırılması
Project Supported by Higher Education Institutions
DURSUN A. (Executive), Özaydın E., GÜLBAKAN B., ÖZGÜL R. K.
2017 - 2018
2017 - 2018From Single to Multiomics Applications and Challenges in Data Integration EMBO toplantısına Bilimsel Başarı Desteği ile katılım
Project Supported by Higher Education Institutions
GÜLBAKAN B. (Executive)
2016 - 2017
2016 - 2017Society of Inborn Errors of MEtabolism Toplantısına katılım için Bilimsel Başarı Desteği Başvurusu
Project Supported by Higher Education Institutions
GÜLBAKAN B. (Executive)
2016 - 2016
2016 - 2016APTAMER-PROTEIN ETKILESIMLERININ NATIVE MS ILE INCELENMESI
Project Supported by Higher Education Institutions
GÜLBAKAN B. (Executive)
2015 - 2016
2015 - 2016