Aptamers: turning the spotlight on cells


LOPEZ-COLON D., JIMENEZ E., YOU M., Gulbakan B. , TAN W.

WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY, cilt.3, ss.328-340, 2011 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 3 Konu: 3
  • Basım Tarihi: 2011
  • Doi Numarası: 10.1002/wnan.133
  • Dergi Adı: WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY
  • Sayfa Sayıları: ss.328-340

Özet

This article is a review of the development and application of aptamer probes for cell imaging. Aptamers selected against whole cells have been modified with different fluorescent dyes and nanomaterials, such as gold nanoparticles, quantum dots, and superparamagnetic iron oxide, for their use as imaging probes of live cells. These probes have been successfully used for cell imaging both in vitro and in vivo by optical imaging, magnetic resonance imaging (MRI), computed tomography (CT), and positron-emission tomography (PET). In this article, we discuss the development of different aptamer-based probes currently available for imaging of live cells and their applications in the biomedical field. (C) 2011 John Wiley & Sons, Inc. WIREs Nanomed Nanobiotechnol 2011 3 328-340 DOI:10.1002/wnan.133