Low indoleamine 2,3-dioxygenase activity in persistent food allergy in children

BUYUKTIRYAKI, AYŞE; ŞAHİNER, ÜMİT; GİRGİN, GÖZDE; BİRBEN, ESRA; SOYER, O.; CAVKAYTAR, O.; ÇETİN, CANSU; YILMAZ, EMİNE; YAVUZ, S.; KALAYCI, O.; BAYDAR, TERKEN; SACKESEN, CANSIN

doi:10.1111/all.12785

Low indoleamine 2,3-dioxygenase activity in persistent food allergy in children

BUYUKTIRYAKI B., ŞAHİNER Ü. M., GİRGİN G., BİRBEN E., SOYER O. U., CAVKAYTAR O., ...More

ALLERGY, vol.71, no.2, pp.258-266, 2016 (SCI-Expanded, Scopus)

Publication Type: Article / Article
Volume: 71 Issue: 2
Publication Date: 2016
Doi Number: 10.1111/all.12785
Journal Name: ALLERGY
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.258-266
Keywords: cell culture, children, food allergy, indoleamine 2, 3-dioxygenase (IDO), tolerance, SUPPRESS TRYPTOPHAN BREAKDOWN, DENDRITIC CELLS, INTERFERON-GAMMA, SERUM TRYPTOPHAN, TOXOPLASMA-GONDII, HUMAN-FIBROBLASTS, INDUCTION, EXPRESSION, TOLERANCE, ACID
Hacettepe University Affiliated: Yes

Abstract

BackgroundIndoleamine 2,3-dioxygenase (IDO), which degrades tryptophan (Trp) to kynurenine (Kyn), has been demonstrated to contribute to modulation of allergic responses. However, the role of IDO in food allergy has not yet been elucidated.