Low indoleamine 2,3-dioxygenase activity in persistent food allergy in children

BUYUKTIRYAKI B., ŞAHİNER Ü. M., GİRGİN G., BİRBEN E., SOYER O. U., CAVKAYTAR O., ...More

ALLERGY, vol.71, no.2, pp.258-266, 2016 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 71 Issue: 2
  • Publication Date: 2016
  • Doi Number: 10.1111/all.12785
  • Journal Name: ALLERGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.258-266
  • Keywords: cell culture, children, food allergy, indoleamine 2, 3-dioxygenase (IDO), tolerance, SUPPRESS TRYPTOPHAN BREAKDOWN, DENDRITIC CELLS, INTERFERON-GAMMA, SERUM TRYPTOPHAN, TOXOPLASMA-GONDII, HUMAN-FIBROBLASTS, INDUCTION, EXPRESSION, TOLERANCE, ACID
  • Hacettepe University Affiliated: Yes

Abstract

BackgroundIndoleamine 2,3-dioxygenase (IDO), which degrades tryptophan (Trp) to kynurenine (Kyn), has been demonstrated to contribute to modulation of allergic responses. However, the role of IDO in food allergy has not yet been elucidated.