Are all phytochemicals useful in the preventing of DNA damage?

BACANLI M., AYDIN DİLSİZ S., BAŞARAN A., Basaran N.

FOOD AND CHEMICAL TOXICOLOGY, vol.109, pp.210-217, 2017 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 109
  • Publication Date: 2017
  • Doi Number: 10.1016/j.fct.2017.09.012
  • Journal Name: FOOD AND CHEMICAL TOXICOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.210-217
  • Keywords: DNA damage, Phytochemicals, INDUCED OXIDATIVE STRESS, URSOLIC ACID, HUMAN-LYMPHOCYTES, ESSENTIAL OILS, D-LIMONENE, IN-VITRO, LIPID-PEROXIDATION, COMET ASSAY, (-)-EPIGALLOCATECHIN GALLATE, EPIGALLOCATECHIN GALLATE
  • Hacettepe University Affiliated: Yes

Abstract

Phytochemicals derived from natural plants have been used commonly for the prevention and/or treatment of different diseases due to the belief of their safety. Many plant species synthesize toxic chemicals. New natural chemicals are being discovered but their toxic effects are unknown. Phytochemicals have been regarded as possible antioxidants. But on the other hand it is suggested that various phenolic antioxidants can display pro-oxidant properties at high doses. In this review, the role of some phytochemicals (epigallocathecin gallate, carvacrol, galangin, limonene, lycopene, naringin, puerarin, terpinene, thymol and ursolic acid) on the prevention of DNA damage will be discussed. (C) 2017 Elsevier Ltd. All rights reserved.