A minireview of quercetin: from its metabolism to possible mechanisms of its biological activities

Ulusoy H. G., Sanlier N.

CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION, cilt.60, sa.19, ss.3290-3303, 2020 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 60 Sayı: 19
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1080/10408398.2019.1683810
  • Dergi Adı: CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, PASCAL, Aerospace Database, Agricultural & Environmental Science Database, Aquatic Science & Fisheries Abstracts (ASFA), BIOSIS, Biotechnology Research Abstracts, CAB Abstracts, CINAHL, Communication Abstracts, Compendex, EMBASE, Food Science & Technology Abstracts, MEDLINE, Metadex, SportDiscus, Veterinary Science Database, Civil Engineering Abstracts
  • Sayfa Sayıları: ss.3290-3303
  • Anahtar Kelimeler: biological activities, diseases, health, quercetin, ONION SKIN EXTRACT, TO-OBESE PATIENTS, OXIDATIVE STRESS, DOUBLE-BLIND, ENDOTHELIAL FUNCTION, BLOOD-PRESSURE, IN-VITRO, FLAVONOID QUERCETIN, DIETARY POLYPHENOLS, PARKINSONS-DISEASE
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Quercetin, one of the most taken flavonoid with diet, belongs to the family of flavonols in which kaempferol and myricetin are also found. Quercetin occurs as a glycoside (with linked sugars) or as an aglycone (without linked sugars). Although quercetin has many different forms in nature, the form found in plants is quercetin-3-O-glucoside, which generally functions as a pigment that gives color to a multitude of fruits and vegetables. The recent literature has been reviewed using PubMed, Science Direct, and Embase databases. In this article, we reviewed quercetin with respect to chemical properties, absorption mechanism, metabolism, bioavailability, food sources, bioactivities, and possible health-promoting mechanisms. Quercetin is known as an antioxidant, anti-inflammatory, cardioprotective, and anti-obesity compound. It is thought to be beneficial against cardiovascular diseases, cancer, diabetes, neurological diseases, obesity, allergy asthma, and atopic diseases. Further clinical studies with large sample sizes are needed to determine the appropriate dose and form of quercetin for preventing diseases.