The purpose of this study was to determine the effect of work engagement and work alienation on performance. Participants included 493 health professionals working in public, university, and private hospitals. Analyses revealed a meaningful and positive relationship of the engagement level of health professionals and its sub-dimensions with their performance, and of work alienation and its sub-dimensions with performance. A regression analysis revealed that the level of participants' engagement and alienation had a significant influence on performance (P < 0.01). Further, among the vigor dimension of engagement and the powerlessness and meaninglessness dimensions of alienation explained 28% of the total variance. These findings reveal that health professionals' vigor levels increase their performance, and powerlessness and meaninglessness levels decrease their performance.