Prof. ÖZDEN TACAL

Publication Network

Articles 39

1. Tramiprosate, the Active Agent of ALZ-801, Modulates Amyloidogenic APP Processing and Tau Phosphorylation in a Cellular Model of Alzheimer's Disease

BİBEROĞLU K., TACAL Ö.

Drug Development Research , vol.87, no.4, 2026 (SCI-Expanded, Scopus)

2. Kinetic analysis suggests that malathion at low environmental exposures is not toxic to humans

Schopfer L. M., TACAL Ö., Masson P., Lockridge O.

PLOS ONE , vol.20, no.10, 2025 (SCI-Expanded, Scopus) Sustainable Development

3. The Role of Thionine on Amyloid Precursor Protein Processing in N2a-APPSwe Cells.

Önder S., Biberoğlu K., Tacal Ö.

Medical Journal of Mugla Sitki Kocman University , vol.12, no.2, pp.161-167, 2025 (Peer-Reviewed Journal)

4. Thionine modulates tau phosphorylation in an Alzheimer's disease cell culture model

Onder S., BİBEROĞLU K., TACAL Ö.

TURKISH JOURNAL OF BIOLOGY , vol.49, no.4, pp.400-408, 2025 (SCI-Expanded, Scopus, TRDizin)

5. Toluidine blue O attenuates tau phosphorylation in N2a-APPSwe cells

Onder S., BİBEROĞLU K., Yuksel M., TACAL Ö.

Chemico-Biological Interactions , vol.366, 2022 (SCI-Expanded, Scopus) Sustainable Development

6. Chlorpyrifos oxon crosslinking of amyloid beta 42 peptides is a new route for generation of self-aggregating amyloidogenic oligomers that promote Alzheimer's disease

Onder S., BİBEROĞLU K., TACAL Ö., Schopfer L. M.

CHEMICO-BIOLOGICAL INTERACTIONS , vol.363, 2022 (SCI-Expanded, Scopus)

7. Effects of toluidine blue O and methylene blue on growth and viability of pancreatic cancer cells

BİBEROĞLU K., YÜKSEL M., ÖNDER S., TACAL Ö.

DRUG DEVELOPMENT RESEARCH , vol.83, no.4, pp.900-909, 2022 (SCI-Expanded, Scopus) Sustainable Development

8. Butyrylcholinesterase in SH-SY5Y human neuroblastoma cells

Onder S., Schopfer L. M., Jiang W., TACAL Ö., Lockridge O.

NeuroToxicology , vol.90, pp.1-9, 2022 (SCI-Expanded, Scopus)

9. Rabbit Antidiethoxyphosphotyrosine Antibody, Made by Single B Cell Cloning, Detects Chlorpyrifos Oxon-Modified Proteins in Cultured Cells and Immunopurifies Modified Peptides for Mass Spectrometry

ÖNDER S., van Grol M., Fidder A., Xiao G., Noort D., Yerramalla U., et al.

JOURNAL OF PROTEOME RESEARCH , vol.20, no.10, pp.4728-4745, 2021 (SCI-Expanded, Scopus)

10. Inhibition of cholinesterases by safranin O: Integration of inhibition kinetics with molecular docking simulations

ÖNDER S., SARI S., TACAL Ö.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS , vol.698, 2021 (SCI-Expanded, Scopus)

11. Characteristic fragment ions associated with dansyl cadaverine and biotin cadaverine adducts on glutamine

BİBEROĞLU K., Schopfer L. M., TACAL Ö., Lockridge O.

ANALYTICAL BIOCHEMISTRY , vol.600, 2020 (SCI-Expanded, Scopus)

12. Chlorpyrifos Oxon-Induced Isopeptide Bond Formation in Human Butyrylcholinesterase

BİBEROĞLU K., TACAL Ö., Schopfer L. M., Lockridge O.

MOLECULES , vol.25, no.3, 2020 (SCI-Expanded, Scopus)

13. The kinetics of inhibition of human acetylcholinesterase and butyrylcholinesterase by methylene violet 3RAX

Onder S., Biberoglu K., Tacal Ö.

CHEMICO-BIOLOGICAL INTERACTIONS , vol.314, 2019 (SCI-Expanded, Scopus) Sustainable Development

14. Trafficking and proteolytic processing of amyloid precursor protein and secretases in Alzheimer's disease development: An up-to-date review

YÜKSEL M., TACAL Ö.

EUROPEAN JOURNAL OF PHARMACOLOGY , vol.856, 2019 (SCI-Expanded, Scopus)

15. Azure B affects amyloid precursor protein metabolism in PS70 cells

BİBEROĞLU K., YÜKSEL M., TACAL Ö.

CHEMICO-BIOLOGICAL INTERACTIONS , vol.299, pp.88-93, 2019 (SCI-Expanded, Scopus) Sustainable Development

16. Mass Spectral Detection of Diethoxyphospho-Tyrosine Adducts on Proteins from HEK293 Cells Using Monoclonal Antibody depY for Enrichment

Önder S., Schopfer L. M., Tacal Ö., Blake T. A., Johnson R. C., Lockridge O.

CHEMICAL RESEARCH IN TOXICOLOGY , vol.31, pp.520-530, 2018 (SCI-Expanded, Scopus)

17. Toluidine blue O modifies hippocampal amyloid pathology in a transgenic mouse model of Alzheimer's disease

YÜKSEL M., BİBEROĞLU K., ÖNDER S., Akbulut K. G., TACAL Ö.

BIOCHIMIE , vol.146, pp.105-112, 2018 (SCI-Expanded, Scopus)

18. Delipidation of Plasma Has Minimal Effects on Human Butyrylcholinesterase

ÖNDER S., TACAL Ö., Lockridge O.

FRONTIERS IN PHARMACOLOGY , vol.9, 2018 (SCI-Expanded, Scopus)

19. Use of Hupresin To Capture Red Blood Cell Acetylcholinesterase for Detection of Soman Exposure

ÖNDER S., SCHOPFER L. M., CASHMAN J. R., TACAL Ö., JOHNSON R. C., BLAKE T. K., et al.

ANALYTICAL CHEMISTRY , vol.90, no.1, pp.974-979, 2018 (SCI-Expanded, Scopus)

20. Monoclonal Antibody That Recognizes Diethoxyphosphotyrosine-Modified Proteins and Peptides Independent of Surrounding Amino Acids

ÖNDER S., Dafferner A. J., Schopfer L. M., Xiao G., Yerramalla U., TACAL Ö., et al.

CHEMICAL RESEARCH IN TOXICOLOGY , vol.30, no.12, pp.2218-2228, 2017 (SCI-Expanded, Scopus) Sustainable Development

21. Hupresin Retains Binding Capacity for Butyrylcholinesterase and Acetylcholinesterase after Sanitation with Sodium Hydroxide

ÖNDER S., DAVID E., TACAL Ö., SCHOPFER L. M., Lockridge O.

FRONTIERS IN PHARMACOLOGY , vol.8, 2017 (SCI-Expanded, Scopus)

22. Effects of phenothiazine-structured compounds on APP processing in Alzheimer's disease cellular model

YÜKSEL M., BİBEROĞLU K., ÖNDER S., Akbulut K. G., TACAL Ö.

BIOCHIMIE , vol.138, pp.82-89, 2017 (SCI-Expanded, Scopus)

23. Azure B reduces extracellular amyloid-beta levels in PS70 cells

BİBEROĞLU K., YÜKSEL TEK M., ÖNDER S., TACAL Ö.

FEBS JOURNAL , vol.283, pp.266, 2016 (SCI-Expanded, Scopus)

24. Toluidine blue O is a potent inhibitor of human cholinesterases

BİBEROĞLU K., TEK M. Y., GHASEMI S., TACAL Ö.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS , vol.604, pp.57-62, 2016 (SCI-Expanded, Scopus) Sustainable Development

25. Healthy F-16 pilots show no evidence of exposure to tri-ortho-cresyl phosphate through the on-board oxygen generating system

Tacal O., Schopfer L. M.

CHEMICO-BIOLOGICAL INTERACTIONS , vol.215, pp.69-74, 2014 (SCI-Expanded, Scopus)

26. Polyproline tetramer organizing peptides in fetal bovine serum acetylcholinesterase

Biberoğlu K., Schopfer L. M., Saxena A., Tacal Ö., Lockridge O.

BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS , vol.1834, no.4, pp.745-753, 2013 (SCI-Expanded, Scopus)

27. Determination of binding points of methylene blue and cationic phenoxazine dyes on human butyrylcholinesterase

Sezgin Z., BİBEROĞLU K., Chupakhin V., Makhaeva G. F., TACAL Ö.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS , vol.532, no.1, pp.32-38, 2013 (SCI-Expanded, Scopus)

28. Resistance of Human Butyrylcholinesterase to Methylene Blue-Catalyzed Photoinactivation; Mass Spectrometry Analysis of Oxidation Products

TACAL Ö., Li B., Lockridge O., Schopfer L. M.

PHOTOCHEMISTRY AND PHOTOBIOLOGY , vol.89, no.2, pp.336-348, 2013 (SCI-Expanded, Scopus)

29. The proline-rich tetramerization peptides in equine serum butyrylcholinesterase

Biberoğlu K., Schopfer L. M., Tacal Ö., Lockridge O.

FEBS JOURNAL , vol.279, no.20, pp.3844-3858, 2012 (SCI-Expanded, Scopus)

30. The role of Phe329 in binding of cationic triarylmethane dyes to human butyrylcholinesterase

BİBEROĞLU K., TACAL Ö., Akbulut H.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS , vol.511, pp.64-68, 2011 (SCI-Expanded, Scopus)

31. Methamidophos, dichlorvos, O-methoate and diazinon pesticides used in Turkey make a covalent bond with butyrylcholinesterase detected by mass spectrometry

TACAL Ö., Lockridge O.

JOURNAL OF APPLIED TOXICOLOGY , vol.30, no.5, pp.469-475, 2010 (SCI-Expanded, Scopus)

32. Comparative Study of the Reduction of Phenoxazine and Phenothiazine Dyes by NADH in Aqueous Solution

Tacal O., Oezer I.

TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI , vol.34, no.3, pp.128-133, 2009 (SCI-Expanded, Scopus, TRDizin)

33. Comparative effects of cationic triarylmethane, phenoxazine and phenothiazine dyes on horse serum butyrylcholinesterase

Yucel Y. Y., TACAL Ö., Ozer I.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS , vol.478, no.2, pp.201-205, 2008 (SCI-Expanded, Scopus)

34. An assessment of the role of intracellular reductive capacity in the biological clearance of triarylmethane dyes

Tacal O., Oezer I.

JOURNAL OF HAZARDOUS MATERIALS , vol.149, no.2, pp.518-522, 2007 (SCI-Expanded, Scopus)

35. Inhibition of choline oxidase by quinoid dyes

Tacal O., Ozer I.

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY , vol.21, no.6, pp.783-787, 2006 (SCI-Expanded, Scopus)

36. Determination of alfa 1 proteinase inhibitor activity and phenotypes in patients with emphysema

TACAL Ö., Sümer N., ÇÖPLÜ L.

Turkish Journal Of Biochemistry-Turk Biyokimya Dergisi , vol.31, pp.169-174, 2006 (TRDizin)

37. Adduct-forming tendencies of cationic triarylmethane dyes with proteins: Metabolic and toxicological implications

Tacal O., Özer İ.

JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY , vol.18, no.5, pp.253-256, 2004 (SCI-Expanded, Scopus)

38. A comparison between SDS-PAGE and size exclusion chromatography as analytical methods for determining product composition in protein conjugation reactions

Tacal O., Özer İ.

JOURNAL OF BIOCHEMICAL AND BIOPHYSICAL METHODS , vol.52, no.3, pp.161-168, 2002 (SCI-Expanded, Scopus)

39. Method dependence of apparent stoichiometry in the binding of salicylate ion to human serum albumin: A comparison between equilibrium dialysis and fluorescence titration

Özer İ., Tacal O.

ANALYTICAL BIOCHEMISTRY , vol.294, no.1, pp.1-6, 2001 (SCI-Expanded, Scopus)

Papers Presented at Peer-Reviewed Scientific Conferences 38

1. The effects of phenothiazine dyes on GAG-modified APLP2 and β-secretase 1 levels in Hs766t cells’’

BİBEROĞLU K., YÜKSEL M., ÖNDER S., TACAL Ö.

TBD Uluslararası Biyokimya Kongresi 2018 // 29. Ulusal Biyokimya Kongresi, 26 - 30 October 2018, (Summary Text)

2. Inhibition of human acetylcholinesterase and butyrylcholinesterase by methylene violet 3RAX

ÖNDER S., BİBEROĞLU K., TACAL Ö.

13th International Meeting on Cholinesterases, 9 - 14 September 2018, (Summary Text)

3. Detection of Diethoxyphospho-tyrosine Adducts on Proteins from HEK 293 Cells Using Monoclonal Antibody DepY for Enrichment

ÖNDER S., Schopfer L. M., TACAL Ö., Blake T. A., Johnson R. C., LOCKRIDGE O.

The 13th International Meeting on Cholinesterases and the 7th International Conference on Paraoxonases, 9 - 14 September 2018, (Summary Text)

4. Toluidine blue O reduces APLP2 and APLP2 CTF levels in Hs766T cells

BİBEROĞLU K., YÜKSEL M., ÖNDER S., TACAL Ö.

43rd FEBS Congress, 7 - 12 July 2018, (Summary Text)

5. The Inhibitory effects of phenothiazine dyes on B-secretase

BİBEROĞLU K., YÜKSEL M., ÖNDER S., TACAL Ö.

12th International Symposium on Pharmaceutical Sciences, 26 - 29 June 2018, (Summary Text)

6. Phenothiazine-structured compounds have different effects on secretases with therapeutic potential in Alzheimer’s disease

YÜKSEL M., TACAL Ö.

12th International Symposium on PharmaceuticalSciences, 26 - 29 June 2018, (Summary Text)

7. What Graduate Students Expect When They Enroll to Graduate Programs of Hacettepe University Institute of Health Sciences: Entrance Poll

KAYA K., PEHLİVANOĞLU B., TACAL Ö., ORHAN D.

International Meeting on Education Research in Health Sciences, 3 - 05 November 2017, (Summary Text)

8. Toluidine blue o but not thionine alters APP procesing in 3XTg-AD mice

YÜKSEL M., BİBEROĞLU K., ÖNDER S., AKBULUT K. G., TACAL Ö.

42nd Congress of the FEBS, 10 - 14 September 2017, vol.284, (Summary Text)

9. Toluidine blue O, but not thionine, alters APP processing in 3xTg-AD mice

YÜKSEL M., BİBEROĞLU K., ÖNDER S., AKBULUT K. G., TACAL Ö.

42nd FEBS CONGRESS, 10 - 14 September 2017, vol.284, (Summary Text)

10. Effect of toluidine blue O on tau pathology in an Alzheimer’xxs disease animal model.

YÜKSEL M., BİBEROĞLU K., ÖNDER S., AKBULUT K. G., TACAL Ö.

FEBS Advanced Lecture Course ALC17-012 Nuclear Receptors and Epigenomic Mechanisms in Human disease and Aging, 26 August - 01 September 2017, (Summary Text)

11. Effect of toluidine blue O on tau pathology in an Alzheimer’s disease animal model

YÜKSEL M., BİBEROĞLU K., ÖNDER S., AKBULUT K. G., TACAL Ö.

FEBS Advanced Lecture Course ALC17-012 Nuclear Receptors and Epigenomic Mechanisms in Human Disease and Aging, Spetses, Greece, 26 August - 01 September 2017, (Summary Text)

12. The General Information About the Active Supervisiors of Hacettepe University Institute of Health Sciences

ÖZTÜRK ÇOPUR E., PEHLİVANOĞLU B., TACAL Ö., ORHAN D.

12th ORPHEUS Conference “PhD Training in Health Sciences and Biomedicine from the Interdiciplinary Perspective, Klaipeda, Lithuania, 4 - 06 May 2017, (Summary Text)

13. EVALUATION OF CURRENT STATUS AND SCIENTIFIC ACTIVITIES OF THE GRADUATE STUDENTS OF HACETTEPE UNIVERSITY INSTITUTE OF HEALTH SCIENCES IN 2016.

ÖZTÜRK ÇOPUR E., PEHLİVANOĞLU B., TACAL Ö., ORHAN D.

12th ORPHEUS Conference, Klaipeda, Lithuania, 4 - 06 May 2017, (Summary Text)

14. Evaluation of Current Status and Scientific Activities of the Graduate Students in Hacettepe University Institute of Health Sciences in 2016

ÖZTÜRK ÇOPUR E., PEHLİVANOĞLU B., TACAL Ö., ORHAN D.

ORPHEUS Conference “PhD Training in Health Sciences and Biomedicine from the Interdiciplinary Perspective”, Klaipeda, Lithuania, 4 - 06 May 2017, (Summary Text)

15. THE GENERAL INFORMATON ABOUT THE ACTIVE SUPERVISORS OF HACETTEPE UNIVERSITY INSTITUTE OF HEALTH SCIENCES IN 2016.

PEHLİVANOĞLU B., ÖZTÜRK ÇOPUR E., TACAL Ö., ORHAN D.

12th ORPHEUS Conference, Klaipeda, Lithuania, 4 - 06 May 2017, (Summary Text)

16. The Graduate’s Perspective for the Education in Hacettepe University Institute of Health Sciences

ÖZTÜRK ÇOPUR E., PEHLİVANOĞLU B., TACAL Ö., ORHAN D.

12th ORPHEUS Conference “PhD Training in Health Sciences and Biomedicine from the Interdiciplinary Perspective, Klaipeda, Lithuania, 4 - 06 May 2017, (Summary Text)