Prasugrel versus clopidogrel for patients with unstable angina or non-ST-segment elevation myocardial infarction with or without angiography: a secondary, prespecified analysis of the TRILOGY ACS trial


Wiviott S. D. , White H. D. , Ohman E. M. , Fox K. A. A. , Armstrong P. W. , Prabhakaran D., ...More

LANCET, vol.382, no.9892, pp.605-613, 2013 (Peer-Reviewed Journal) identifier identifier

  • Publication Type: Article / Article
  • Volume: 382 Issue: 9892
  • Publication Date: 2013
  • Doi Number: 10.1016/s0140-6736(13)61451-8
  • Journal Name: LANCET
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.605-613

Abstract

Background Treatment with prasugrel and aspirin improves outcomes compared with clopidogrel and aspirin for patients with acute coronary syndrome who have had angiography and percutaneous coronary intervention; however, no clear benefit has been shown for patients managed first with drugs only. We assessed outcomes from the TRILOGY ACS trial based on whether or not patients had coronary angiography before treatment was chosen.