Motor repertoire is age-inadequate in infants with cystic fibrosis

TEKERLEK H., MUTLU A., İNAL İNCE D., LİVANELİOĞLU A., Kahraman A., Eryilmaz-Polat S., ...More

PEDIATRIC RESEARCH, vol.89, no.5, pp.1291-1296, 2021 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 89 Issue: 5
  • Publication Date: 2021
  • Doi Number: 10.1038/s41390-020-1082-4
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, CAB Abstracts, CINAHL, EMBASE, MEDLINE, Sociological abstracts, Veterinary Science Database
  • Page Numbers: pp.1291-1296
  • Hacettepe University Affiliated: Yes


Background General movements (GMs) in infants occur as fidgety movements (FMs) between postterm 9 and 20 weeks. We aimed to evaluate FMs and motor repertoire in infants with cystic fibrosis (CF) and their relation with clinical findings. Methods Demographic and clinical characteristics were recorded. FMs and motor repertoire were analyzed from a 5-min video recording of each infant. Videos were rated based on the Prechtl General Movement Assessment and motor optimality score (MOS) was calculated. Results The analysis included 18 infants with CF and 20 healthy infants at postterm age of 3-5 months. MOS was significantly lower in the infants with CF compared to controls (p < 0.05). Fifty percent of the infants with CF had abnormal or absent/sporadic FMs. MOS was negatively associated with hospitalization duration (r = -0.378,p = 0.036); and positively associated with vitamin A level in CF infants (r = 0.665,p = 0.026). Conclusions Infants with genetically anticipated severe CF phenotype tended to have lower MOS. MOS may be used in addition to genetic testing to predict disease severity in infants with CF. Infants with CF, absent/sporadic FMs, and lower MOS could be considered for planning specific age-adequate early intervention programs. Impact