Type I IFN-related NETosis in ataxia telangiectasia and Artemis deficiency

Gul, Ersin; Sayar, Esra; Gungor, Bilgi; Eroglu, Fehime; Surucu, Naz; Keles, Sevgi; Guner, Sukru; Findik, Siddika; Alpdundar, ESİN; AYANOĞLU, İHSAN; Kayaoglu, Basak; Geckin, Busra; Sanli, Hatice; Kahraman, Tamer; Yakicier, Cengiz; Muftuoglu, Meltem; Oguz, Berna; Ayvaz, DENİZ; Gursel, Ihsan; Ozen, Seza; Reisli, Ismail; Gursel, Mayda

doi:10.1016/j.jaci.2017.10.030

Type I IFN-related NETosis in ataxia telangiectasia and Artemis deficiency

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Gul E., Sayar E. H., Gungor B., Eroglu F. K., Surucu N., Keles S., ...More

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, vol.142, no.1, pp.246-257, 2018 (SCI-Expanded)

Publication Type: Article / Article
Volume: 142 Issue: 1
Publication Date: 2018
Doi Number: 10.1016/j.jaci.2017.10.030
Journal Name: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.246-257
Keywords: Primary immunodeficiencies, autoinflammation, ataxia telangiectasia, Artemis deficiency, type I IFN, interferonopathy, neutrophil extracellular traps, NETosis, NEUTROPHIL EXTRACELLULAR TRAPS, SYSTEMIC-LUPUS-ERYTHEMATOSUS, ACUTE MYOCARDIAL-INFARCTION, COMBINED IMMUNODEFICIENCY, CUTANEOUS GRANULOMAS, MITOCHONDRIAL-DNA, DCLRE1C MUTATIONS, DISEASE, DAMAGE, INTERFERONOPATHIES
Hacettepe University Affiliated: Yes

Abstract

Background: Pathological inflammatory syndromes of unknown etiology are commonly observed in ataxia telangiectasia (AT) and Artemis deficiency. Similar inflammatory manifestations also exist in patients with STING-associated vasculopathy in infancy (SAVI).