Type I IFN-related NETosis in ataxia telangiectasia and Artemis deficiency

Gul, Ersin; Sayar, Esra; Gungor, Bilgi; Eroglu, Fehime; Surucu, Naz; Keles, Sevgi; Guner, Sukru; Findik, Siddika; Alpdundar, ESİN; AYANOĞLU, İHSAN; Kayaoglu, Basak; Geckin, Busra; Sanli, Hatice; Kahraman, Tamer; Yakicier, Cengiz; Muftuoglu, Meltem; Oguz, Berna; Ayvaz, DENİZ; Gursel, Ihsan; Ozen, Seza; Reisli, Ismail; Gursel, Mayda

doi:10.1016/j.jaci.2017.10.030

Type I IFN-related NETosis in ataxia telangiectasia and Artemis deficiency

Gul E., Sayar E. H., Gungor B., Eroglu F. K., Surucu N., Keles S., ...More

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, vol.142, no.1, pp.246-257, 2018 (SCI-Expanded, Scopus)

Publication Type: Article / Article
Volume: 142 Issue: 1
Publication Date: 2018
Doi Number: 10.1016/j.jaci.2017.10.030
Journal Name: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.246-257
Keywords: Primary immunodeficiencies, autoinflammation, ataxia telangiectasia, Artemis deficiency, type I IFN, interferonopathy, neutrophil extracellular traps, NETosis, NEUTROPHIL EXTRACELLULAR TRAPS, SYSTEMIC-LUPUS-ERYTHEMATOSUS, ACUTE MYOCARDIAL-INFARCTION, COMBINED IMMUNODEFICIENCY, CUTANEOUS GRANULOMAS, MITOCHONDRIAL-DNA, DCLRE1C MUTATIONS, DISEASE, DAMAGE, INTERFERONOPATHIES
Open Archive Collection: AVESIS Open Access Collection
Hacettepe University Affiliated: Yes

Abstract

Background: Pathological inflammatory syndromes of unknown etiology are commonly observed in ataxia telangiectasia (AT) and Artemis deficiency. Similar inflammatory manifestations also exist in patients with STING-associated vasculopathy in infancy (SAVI).