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Turkish Journal of Gastroenterology, vol.7, no.1, pp.72-81, 1996 (Scopus)
Today adjuvant therapy using early postoperative intraperitoneal chemotherapy, is particularly appropriate treatment to prevent the local and regional recurrence in resectable colon cancers. Intraperitoneal 5-Fluorouracil (5-FU) is the most preferable agent for this purpose. The aim of this study is to determine the effect of Zn against the inhibitory effect of 5-FU on the healing of colonic anastomosis. In 5-FU treated group, average bursting pressure (p:0.048) and hydroxyproline levels were significantly decreased (p:0.015). In only Zn treated group, average bursting pressure was significantly increased (p:0.02) whereas hydroxyproline levels showed no correlation with the control group (p:0.560). In both 5-FU and Zn treated groups average bursting pressure had statistically significant correlation only with the 5-FU treated group (p:0.014). In this group hydroxyproline levels were increased as well (p:0.014). The histological observations showed that 5-FU impaired the healing of colonic anastomosis with the appearance of necrotic tissue at the anastomosis region. However the 5-FU and Zn groups appeared to be nearly completely epithelialized and also the number of fibroblasts were increased while necrotic tissue was not as much as in the 5-FU treated group. We conclude that Zn addition modulates healing of colonic anastomosis by counteracting the negative effect of 5-FU.