Prevention of the inhibitory effect of intraperitoneal 5-FU on intestinal anastomosis by zinc 5-FU'NUN INTRAPERITONEAL KULLANIMINDA INTESTINAL ANASTOMOZ UZERINE OLAN OLUMSUZ ETKISINIIN CINKO ILE ENGELLENMESI
Turkish Journal of Gastroenterology, cilt.7, sa.1, ss.72-81, 1996 (Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 7 Sayı: 1
- Basım Tarihi: 1996
- Dergi Adı: Turkish Journal of Gastroenterology
- Derginin Tarandığı İndeksler: Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.72-81
- Anahtar Kelimeler: 5-Fluorouracil, Colon anastomosis, Histopathology, Zinc
- Hacettepe Üniversitesi Adresli: Evet
Özet
Today adjuvant therapy using early postoperative intraperitoneal chemotherapy, is particularly appropriate treatment to prevent the local and regional recurrence in resectable colon cancers. Intraperitoneal 5-Fluorouracil (5-FU) is the most preferable agent for this purpose. The aim of this study is to determine the effect of Zn against the inhibitory effect of 5-FU on the healing of colonic anastomosis. In 5-FU treated group, average bursting pressure (p:0.048) and hydroxyproline levels were significantly decreased (p:0.015). In only Zn treated group, average bursting pressure was significantly increased (p:0.02) whereas hydroxyproline levels showed no correlation with the control group (p:0.560). In both 5-FU and Zn treated groups average bursting pressure had statistically significant correlation only with the 5-FU treated group (p:0.014). In this group hydroxyproline levels were increased as well (p:0.014). The histological observations showed that 5-FU impaired the healing of colonic anastomosis with the appearance of necrotic tissue at the anastomosis region. However the 5-FU and Zn groups appeared to be nearly completely epithelialized and also the number of fibroblasts were increased while necrotic tissue was not as much as in the 5-FU treated group. We conclude that Zn addition modulates healing of colonic anastomosis by counteracting the negative effect of 5-FU.