Increased soluble FAS suggests delayed apoptosis in familial Mediterranean fever complicated with amyloidosis

Kiraz S., Ertenli I., Ozturk M., Haznedaroglu I., Calguneri M., Atalar E., ...More

JOURNAL OF RHEUMATOLOGY, vol.30, no.2, pp.313-315, 2003 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 30 Issue: 2
  • Publication Date: 2003
  • Journal Name: JOURNAL OF RHEUMATOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.313-315
  • Hacettepe University Affiliated: Yes

Abstract

Objective. Interactions of the FAS with FAS ligand have been proposed as a major regulatory mechanism of immune homeostasis. Soluble FAS (sFAS) acts as a competitive antagonist to FAS, thereby inhibiting FAS mediated apoptosis. sFAS concentrations have been studied in various autoimmune diseases, with controversial results. In this cross sectional study, we investigated the role of sFAS protein in attack-free patients with familial Mediterranean fever (FMF) with and without amyloidosis.