Increased soluble FAS suggests delayed apoptosis in familial Mediterranean fever complicated with amyloidosis


Kiraz S., Ertenli I., Ozturk M., Haznedaroglu I. , Calguneri M., Atalar E., ...Daha Fazla

JOURNAL OF RHEUMATOLOGY, cilt.30, sa.2, ss.313-315, 2003 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 30 Konu: 2
  • Basım Tarihi: 2003
  • Dergi Adı: JOURNAL OF RHEUMATOLOGY
  • Sayfa Sayıları: ss.313-315

Özet

Objective. Interactions of the FAS with FAS ligand have been proposed as a major regulatory mechanism of immune homeostasis. Soluble FAS (sFAS) acts as a competitive antagonist to FAS, thereby inhibiting FAS mediated apoptosis. sFAS concentrations have been studied in various autoimmune diseases, with controversial results. In this cross sectional study, we investigated the role of sFAS protein in attack-free patients with familial Mediterranean fever (FMF) with and without amyloidosis.