Sacituzumab govitecan vs. chemotherapy for metastatic breast cancer: a meta-analysis on safety outcomes

Rizzo A., Rinaldi L., Massafra R., Cusmai A., GÜVEN D. C., Forgia D. L., ...More

FUTURE ONCOLOGY, vol.20, no.20, pp.1427-1434, 2024 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 20 Issue: 20
  • Publication Date: 2024
  • Doi Number: 10.1080/14796694.2024.2354162
  • Journal Name: FUTURE ONCOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CINAHL, EMBASE, MEDLINE
  • Page Numbers: pp.1427-1434
  • Hacettepe University Affiliated: Yes

Abstract

Aim: There is limited data available regarding the comparison of Sacituzumab govitecan (SG) vs. chemotherapy in metastatic breast cancer patients. Materials & methods: We performed a systematic review and meta-analysis aimed to assess the safety profile of SG vs. chemotherapy for metastatic breast cancer (mBC) clinical trials. Results: The pooled odds ratio for outcomes such as grade 3-4 and all grade neutropenia, leukopenia, anemia and other non-hematological adverse events showed a higher risk for patients receiving SG. No statistically significant differences were reported in terms of grade 3-4 fatigue, all grade nausea, febrile neutropenia and treatment discontinuation due to adverse events. Conclusion: Our data, coupled with a statistically and clinically meaningful survival benefit, support the use of SG for mBC.