Acute Graft-Versus-Host Disease: A Brief Review

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ALADAĞ KARAKULAK E., KELKİTLİ E., GÖKER H.

TURKISH JOURNAL OF HEMATOLOGY, cilt.37, sa.1, ss.1-4, 2020 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 37 Sayı: 1
  • Basım Tarihi: 2020
  • Doi Numarası: 10.4274/tjh.galenos.2019.2019.0157
  • Dergi Adı: TURKISH JOURNAL OF HEMATOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CINAHL, EMBASE, MEDLINE, Directory of Open Access Journals, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.1-4
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Graft-versus-host disease (GvHD) is an important complication that can be observed after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Acute GvHD (aGvHD) is seen after alloHSCT and the incidence of aGvHD is around 30%-50%. aGvHD prophylaxis is essential in patients undergoing allo-HSCT. Initial therapy for aGvHD is steroids. Prognosis is poor in aGvHD patients not responding to steroids. In this article, the pathobiology, clinical findings, prophylaxis, and treatment of aGvHD will be summarized.