Acute Graft-Versus-Host Disease: A Brief Review

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ALADAĞ KARAKULAK E., KELKİTLİ E., GÖKER H.

TURKISH JOURNAL OF HEMATOLOGY, vol.37, no.1, pp.1-4, 2020 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 37 Issue: 1
  • Publication Date: 2020
  • Doi Number: 10.4274/tjh.galenos.2019.2019.0157
  • Journal Name: TURKISH JOURNAL OF HEMATOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CINAHL, EMBASE, MEDLINE, Directory of Open Access Journals, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.1-4
  • Hacettepe University Affiliated: Yes

Abstract

Graft-versus-host disease (GvHD) is an important complication that can be observed after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Acute GvHD (aGvHD) is seen after alloHSCT and the incidence of aGvHD is around 30%-50%. aGvHD prophylaxis is essential in patients undergoing allo-HSCT. Initial therapy for aGvHD is steroids. Prognosis is poor in aGvHD patients not responding to steroids. In this article, the pathobiology, clinical findings, prophylaxis, and treatment of aGvHD will be summarized.