Effects of radiation on carbapenems: ESR identification and dosimetric features of gamma irradiated solid meropenem trihydrate


Tepe S., Polat M. , Korkmaz M.

RADIATION EFFECTS AND DEFECTS IN SOLIDS, cilt.161, ss.653-664, 2006 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 161 Konu: 11
  • Basım Tarihi: 2006
  • Doi Numarası: 10.1080/10420150600903417
  • Dergi Adı: RADIATION EFFECTS AND DEFECTS IN SOLIDS
  • Sayfa Sayıları: ss.653-664

Özet

In the present work, effects of gamma radiation on solid meropenem trihydrate (MPT), which is the active ingredient of carbapenem antibiotics, were investigated by electron spin resonance (ESR) spectroscopy. Irradiated MPT presents an ESR spectrum consisting of many resonance peaks. Heights measured with respect to the spectrum baseline of these resonance peaks were used to explore the evolutions of the radicalic species responsible for the experimental spectrum under different conditions. Variations of the denoted 11 peak heights with microwave power, sample temperature and applied radiation doses and decay of the involved radicalic species at room and at high temperatures were studied. On the basis of the results derived from these studies, a molecular model consisting of the presence of four different radicalic species was proposed, and spectroscopic parameters of these species were calculated through spectrum simulation calculations. The dosimetric potential of MPT was also explored and it was concluded that MPT presents the characteristics of normal and accidental dosimetric materials.