A New Generation of Dihydropyridine Calcium Channel Blockers: Photostabilization of Liquid Formulations Using Nonionic Surfactants


Ioele G., GÜNDÜZ M. G. , SPATARI C., DE LUCA M., GRANDE F., RAGNO G.

PHARMACEUTICS, vol.11, no.1, 2019 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 11 Issue: 1
  • Publication Date: 2019
  • Doi Number: 10.3390/pharmaceutics11010028
  • Journal Name: PHARMACEUTICS
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Keywords: 1,4-dihydropyridines, L- and T-type calcium channel blockers, photodegradation test, light-stable formulation, micellar solution, PET containers, 1,4-DIHYDROPYRIDINE ANTIHYPERTENSIVES, DERIVATIVE SPECTROPHOTOMETRY, PHOTODEGRADATION PRODUCT, CYCLODEXTRIN

Abstract

The stability profile of a new 1,4-dihydropyridine derivative (DHP), representative of a series with a hexahydroquinoline ring, was studied to design light-stable liquid formulations. This molecule, named M3, has been shown among the analogs to have a high capacity to block both Land T-type calcium channels. The ethanol solution of the drug was subjected to a photodegradation test, in accordance with standard rules. The concentrations of the drug and its byproducts were estimated using multivariate curve resolution, applied to the spectral data collected during the test. The improvement of both the photostability and water solubility of M3 was investigated by adding the surfactant polysorbate 20 in a 1:5 ratio to aqueous solutions of the drug. These formulations were exposed to stressing light in containers of bleu polyethylene terephthalate (PET), amber PET, and covered amber PET. The best results were obtained when using the covered amber PET container, reaching a degradation percentage of the drug less than 5% after 12 h under an irradiance power of 450 W/m(2). The stability of the compound was compared to that of nimodipine (NIM) under the same conditions.