Xanthones and Xanthone O-beta-D-Glucosides from the Roots of Polygala azizsancarii Donmez

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Atıf İçin Kopyala

ÇALIŞ İ., Unlu A., UĞURLU AYDIN Z., Donmez A. A., Yusufoglu H. S., Jurt S., ...Daha Fazla

CHEMISTRY & BIODIVERSITY, cilt.19, 2022 (SCI-Expanded)

• Yayın Türü: Makale / Tam Makale
• Cilt numarası: 19
• Basım Tarihi: 2022
• Doi Numarası: 10.1002/cbdv.202200499
• Dergi Adı: CHEMISTRY & BIODIVERSITY
• Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Aquatic Science & Fisheries Abstracts (ASFA), CAB Abstracts, Chemical Abstracts Core, EMBASE, MEDLINE, Veterinary Science Database
• Anahtar Kelimeler: Polygala azizsancarii, Polygalaceae, xanthones, sancarosides A and B, crystal structure, INHIBITORS, EXTRACT, MARKER
• Hacettepe Üniversitesi Adresli: Evet

Özet

Nine xanthone derivatives (1-9) were isolated from the roots of Polygala azizsancarii, which is a narrow endemic species for the flora of Turkiye. Based on all of the evidence, the structures of 1-9 were established as two previously undescribed xanthone O-glucosides, 3-O-beta-D-glucopyranosyloxy-1,6-dihydroxy-2,5,7-trimethoxyxanthone (1), 3-O-beta-D-glucopyranosyloxy-1,6-dihydroxy-2,7-dimethoxyxanthone (2), and seven previously described xanthones, 1,3,6-trihydroxy-2,5,7-trimethoxyxanthone (3), 1,3,6-trihydroxy-2,7-dimethoxyxanthone (4), 1,2,3,4,7-pentamethoxyxanthone (5), 1,3-dihydroxy-2,5,6,7-tetramethoxyxanthone (6), 1,3-dihydroxy-4,7-dimethoxyxanthone (7), 1,7-dihydroxy-3-methoxyxanthone (8), and 1,7-dihydroxy-2,3-methylenedioxyxanthone (9). The structures of the compounds were determined by spectroscopic methods, including 1D-NMR (H-1-NMR, C-13-NMR, DEPT-135), 2D-NMR (COSY, NOESY, HSQC, HMBC, INADEQUATE), and HR-MS. The solid-state structures of 1-4, including the absolute configurations of the stereogenic carbons of the sugar moiety in 1 and 2, were established by X-ray crystal-structure analyses. For the newly described compounds, the trivial names sancarosides A (1) and B (2) are proposed.