Akademik Veri Yönetim Sistemi
Ankara Universitesi Eczacilik Fakultesi Dergisi, cilt.45, sa.3, ss.652-673, 2021 (Scopus)
© 2021 University of Ankara. All rights reserved.Objective: Resveratrol (trans-3,5,4'-trihydroxy-stilbene) is a polyphenolic compound found in many plant sources such as grapes, vine, peanuts, cranberries, blueberries. While previous research on resveratrol has focused on its pharmacological effects on cardiovascular systems, inflammation, and carcinogenesis/cancer development, most of the research has recently been expanded by exploring its potential effects on the aging process, diabetes, Alzheimer's, and other neurodegenerative diseases. Within the scope of this review, it is aimed to compile general information about resveratrol, its sources, and especially its biological effects (in vitro, in vivo) studied in recent years. Result and Discussion: Resveratrol is structurally dominated by the trans-form. It is found in plants as glycosides that are more stable and resistant to oxidative degradation. Various extracts of the Polygonum cuspidatum plant, which are frequently used in the production of resveratrol, have led to the emergence of commercially important products. Resveratrol is a molecule that has mainly anti-inflammatory, antioxidant, anticancer, and cardioprotective effects. In pharmacokinetic studies, it has been reported that resveratrol is well absorbed, rapidly metabolized in the form of sulfate and glucuronide conjugates due to its first-pass effect, and eliminated in the urine. Besides, resveratrol has been reported to be well-tolerated and to show no apparent toxicity. Considering the bioavailability of resveratrol, which can be taken as food/nutraceutical or as a medicine, to benefit from the various effects on human health, it was concluded that tablet, capsule, and nanoparticle formulations containing well-formulated resveratrol should be prepared and used.