Memory T cell responses in seronegative older adults following SARS-CoV-2 vaccination
Clinical Immunology Communications, cilt.2, ss.154-158, 2022 (Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 2
- Basım Tarihi: 2022
- Doi Numarası: 10.1016/j.clicom.2022.09.005
- Dergi Adı: Clinical Immunology Communications
- Derginin Tarandığı İndeksler: Scopus
- Sayfa Sayıları: ss.154-158
- Anahtar Kelimeler: COVID-19, Memory T cell responses, Vaccine
- Hacettepe Üniversitesi Adresli: Evet
Özet
Generating memory T cell responses besides humoral immune responses is essential when it comes to the efficacy of a vaccine. In this study, the presence of memory T cell responses after aluminum-adjuvanted inactivated whole-virion SARS-CoV-2 vaccine (CoronaVac) in seronegative and seropositive elderly individuals were examined. CD4+ and CD8+ memory T cell proliferation and IFN-γ production capacities were evaluated. Additionally, clinical frailty scale (CFS) and FRAIL scales of the individuals were scored. CD4+ memory T cell responses more prominent than CD8+ memory T cells. In seronegative individuals, 80% of them had memory CD4+ and IFN-γ, whereas 50% of them had memory CD4+ and all of them had IFN-γ responses. Additionally, 40% of seronegative patients and 50% of seropositive patients had memory CD8+ responses. To sum up, humoral immune responses are not associated with memory T cell responses, and in seronegative individuals, memory T cell responses can be detected.