Rheological Properties of Hyaluronic Acid Diluted Solutions as Components of Cosmetics
BIOINTERFACE RESEARCH IN APPLIED CHEMISTRY, cilt.12, sa.2, ss.1907-1915, 2022 (ESCI, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 12 Sayı: 2
- Basım Tarihi: 2022
- Doi Numarası: 10.33263/briac122.19071915
- Dergi Adı: BIOINTERFACE RESEARCH IN APPLIED CHEMISTRY
- Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus
- Sayfa Sayıları: ss.1907-1915
- Anahtar Kelimeler: hyaluronic acid, molecular weight, MALDI, viscosity, theological properties, technology, MOLECULAR-WEIGHT
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Hacettepe Üniversitesi Adresli: Evet
Özet
Rheological measurements were carried out on dilute aqueous solutions of high (HMW-HA, 1150 kDa) and low molecular eight hyaluronic acids (LMW-HA, 8 kDa) along with their mixtures to determine the relationship between the viscosity and concentration of the samples, Molecular weight and polydispersity of low molecular HA have been determined by matrix-assisted laser desorption ionization mass spectrometry (MALDI-MS). HA diluted solutions ere found to be weakly structured liquids with a slight viscosity anomaly. Critical aloes of concentration ere determined at different ratios of HMW-HA and LMW-HA leading to a sharp increase in the viscosity of solutions. Rheological studies have proved the pseudoplastic nature of the viscous flow of HMW-HA solutions. The possibility of using the Ostwald-de Wale equation for the mathematical description of a viscous flow was established. The results of the 'theological analysis might be applied for the rational development of cosmetic formulations containing hyaluronic acid of various molecular weights.