SYNTHESIS AND PHARMACOLOGY OF SOME NEW CARBAMODITHIOIC ACID-ESTERS


SAFAK C., ERDOGAN H., YESILADA A., EROL K., CIMGI I.

ARZNEIMITTELFORSCHUNG-DRUG RESEARCH, no.2, pp.123-126, 1992 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Publication Date: 1992
  • Journal Name: ARZNEIMITTELFORSCHUNG-DRUG RESEARCH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, International Pharmaceutical Abstracts
  • Page Numbers: pp.123-126
  • Hacettepe University Affiliated: No

Abstract

In this study 13 new dithiocarbamates were prepared by reacting 3-methyl-6-chloroacetyl-benzoxazolinone with potassium N,N-disubstituted dithiocarbamate derivatives. The structures of the compounds were confirmed by UV, IR, H-1-NMR, mass spectroscopic methods and elementary analysis. The anticholinergic activity was tested on rabbit ileum. With exception of one compound all derivatives exhibited a stronger antihistaminic activity as compared with their anticholinergic action.