Biogenic Production and Characterization of CuO Nanoparticles by Carica papaya Leaves and Its Biocompatibility Applications

Dulta K., KOŞARSOY AĞÇELİ G., Chauhan P., Chauhan P. K.

JOURNAL OF INORGANIC AND ORGANOMETALLIC POLYMERS AND MATERIALS, vol.31, pp.1846-1857, 2021 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 31
  • Publication Date: 2021
  • Doi Number: 10.1007/s10904-020-01837-7
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Chemical Abstracts Core, Chimica, Compendex, INSPEC
  • Page Numbers: pp.1846-1857
  • Keywords: Green synthesis, Carica papaya, Copper oxide nanoparticles, Antioxidant, Anticancer
  • Hacettepe University Affiliated: Yes


Nowadays, environmentally friendly, economical and efficient production of nanoparticles is increasingly important. The most appropriate nanoparticle synthesis that can be used in this process is green synthesis performed with biological materials (bacteria, fungi or plant). Metallic nanoparticles can be used in many applications and several studies have been conducted to use these particles as antimicrobial and anticancer agents. However, there are limited studies on the green synthesis and biocompatibility of nanocrystalline copper oxide. In this study extracts of Carica papaya leaves were used for the production of copper oxide (CuO) nanoparticles (NPs). UV-Vis spectral analysis showed copper nanoparticles exhibit an absorption peak at around 250 nm. The CuO NPs were analysed with Fourier transform infrared spectroscopy (FT-IR), Scanning electron microscope (SEM), X-ray diffraction (XRD) spectrum and Dynamic light scattering (DLS). The SEM and XRD analysis exposed CuO NPs are spherical in shape with an average particle size of 77 nm. Further, as-formed CuO NPs exhibit significant antioxidant and anticancer activity.